Anti-aging movement. DNA repair. Free radicals. Genetics of aging. Geriatrics. Gerontology. Homeostatic capacity. Immortality. Indefinite lifespan. Life extension. Index of topics related to life extension. Mitohormesis. Old age. Oxidative stress. Phenoptosis. Plant senescence. Programmed cell death. Regenerative medicine. Rejuvenation. SAGE KE. Stem cell theory of aging. Strategies for Engineered Negligible Senescence (SENS). Sub-lethal damage. Timeline of senescence research. Transgenerational design.

Aubrey de Grey

Dr. [Aubrey] de Greyde Grey, Dr. Aubrey
He works on the development of what he calls "Strategies for Engineered Negligible Senescence" (SENS), a collection of proposed techniques to rejuvenate the human body and stop aging. To this end, he has identified seven types of molecular and cellular damage caused by essential metabolic processes. SENS is a proposed panel of therapies designed to repair this damage. De Grey is an international adjunct professor of the Moscow Institute of Physics and Technology, a fellow of the Gerontological Society of America, the American Aging Association, and the Institute for Ethics and Emerging Technologies.

Negligible senescence

biological immortalitydo not gradually break downexceptions
Strategies for Engineered Negligible Senescence.

Outline of life extension

Also known as anti-aging medicine, experimental gerontology, and biomedical gerontology. Theories of aging * Ending Aging, a 2007 book which describes Aubrey de Grey's medical proposal for defeating aging (i.e. SENS). Biological immortality. Indefinite lifespan. Longevity. Rejuvenation. Centenarian. Supercentenarian. Longevity escape velocity. Calorie restriction or protein restriction or intermittent fasting. Exercise. Geroprotector. Senolytics. Cryonics. Genetic therapies. Cloning and body part replacement. Cell replacement therapies (CRT). SENS (Strategies for Engineered Negligible Senescence). Mind uploading. Suspended animation. Immunisation. Evolution of ageing. Gerontology.

Index of topics related to life extension

SENS Foundation. Shaw, Sandy. Sierra Sciences. Sleep deprivation. Sports medicine. Stem cell. Stem cell treatments. Stone, Irwin. Strategies for Engineered Negligible Senescence. Superoxide dismutase (SOD). Superoxide. Technological determinism. Technological evolution. Technological singularity. Technology assessment. Techno-progressivism. Techno-utopianism. Telomere. Therapeutic cloning. Theories of aging. Antagonistic pleiotropy theory of aging. Disposable soma theory of aging. Free-radical theory. Glycation theory of aging. Inflammation theory of aging. Neuroendocrine theory of aging. Order to disorder theory of aging. Rate of living theory. Reliability theory of aging and longevity.

Marios Kyriazis

Anti-aging movement. Biological Immortality. The British Longevity Society. The ELPIS Foundation for Indefinite Lifespans website.


immortalimmortality of the souleternal life
Eliminating aging would require finding a solution to each of these causes, a program de Grey calls engineered negligible senescence. There is also a huge body of knowledge indicating that change is characterized by the loss of molecular fidelity. Disease is theoretically surmountable via technology. In short, it is an abnormal condition affecting the body of an organism, something the body shouldn't typically have to deal with its natural make up. Human understanding of genetics is leading to cures and treatments for a myriad of previously incurable diseases. The mechanisms by which other diseases do damage are becoming better understood.

Indefinite lifespan

actuarial escape velocityindefinitelylive forever
However, if biomedical gerontology continues to improve, if somatic genetic engineering becomes safe and effective (and is not banned by opponents) within the relatively near future, it may be conceivable for some of those now alive to attain indefinite lifespans. Strategies for Engineered Negligible Senescence is a proposed research program for repairing all types of age-related damage. Calorie restriction has been presented as a piece of the puzzle of reaching actuarial escape velocity. Other proposed techniques include genetic engineering, telomere extension, organ regeneration, nanotechnology, and even mind uploading.


Anti-ageing movement. Biodemography of human longevity. Biogerontology. Biological immortality. Biomarkers of ageing. Clinical geropsychology. Death. Epigenetic clock. Evolution of ageing. Genetics of ageing. Gerontology. List of life extension-related topics. Longevity. Old age. Population ageing. Progeria. Stem cell theory of ageing. Supercentenarian. Transgenerational design. Neuroscience of ageing. Ageing studies. Global AgeWatch Statistics on population ageing and life expectancy. HelpAge International and UNFPA (2012). Ageing in the 21st Century – A Celebration and a Challenge.

Life extension

anti-aginganti-aging medicinelife-extension
Anti-aging movement. Biological immortality. Centenarian. Clinical Interventions in Aging. Dementia. DNA damage theory of aging. Human enhancement. Immortality. Maximum lifespan. Rejuvenation Research. Senescence. Slow aging. Supercentenarian. Timeline of senescence research. Transgenerational design. Greg Easterbrook, "What Happens When We All Live to 100?, The Atlantic, October 2014, pp. 60–72. Ezekiel J. Emanuel, Why I Hope to Die at 75, The Atlantic, October 2014, pp. 74–81. Aubrey de Grey: 'We will be able to live to 1,000'. Life extension on Wikiversity. The Fable of the Dragon Tyrant by philosopher Nick Bostrom - arguing for life extension research.

Aging-associated diseases

age-related diseaseaging-associated diseaseage-associated disease
Strategies for Engineered Negligible Senescence (SENS) is a research strategy which aims to repair a few "root causes" for age-related illness and degeneration, as well as develop medical procedures to periodically repair all such damage in the human body, thereby maintaining a youth-like state indefinitely. So far, the SENS programme has identified seven types of aging-related damage, and feasible solutions have been outlined for each. However, critics argue that the SENS agenda is optimistic at best, and that the aging process is too complex and little-understood for SENS to be scientific or implementable in the foreseeable future.


geriatricgeriatric medicinegeriatrician
Gerontological nursing. Merck Manual of Geriatrics. Minimum Geriatric Competencies - Portal of Geriatric Online Education. Health-EU Portal Care for the elderly in the EU.


Gerontology specializes in the science of human aging processes. Organisms showing only asexual reproduction (e.g. bacteria, some protists, like the euglenoids and many amoebozoans) and unicellular organisms with sexual reproduction (colonial or not, like the volvocine algae Pandorina and Chlamydomonas) are "immortal" at some extent, dying only due to external hazards, like being eaten or meeting with a fatal accident.


life spanlong-livedlifespan
Anti-aging movement. Biodemography. Biodemography of human longevity. Calico (company). Centenarian. DNA damage theory of aging. Genetics of aging. Gerontology Research Group. Hayflick limit. Indefinite lifespan. Life extension. List of aging processes. List of last survivors of historical events. Longevity claims. Maximum life span. Mitohormesis. Oldest viable seed. Reliability theory of aging and longevity. Research into centenarians. Senescence. Lucian Boia (2005) Forever Young: A Cultural History of Longevity from Antiquity to the Present Door Reaktion Books. ISBN: 1-86189-154-7. James R. Carey & Debra S.

Maximum life span

maximum lifespanlifespanlife span
Gerontology. Hayflick limit. Indefinite lifespan. Life expectancy. Life extension. List of long-living organisms. Longevity. Methuselah Mouse Prize. Michael Ristow. Mitohormesis. Oldest people. Senescence. Strategies for Engineered Negligible Senescence (SENS). Anage Database. Informational website on the biology of aging. Mechanisms of Aging.

Rejuvenation Research

The journal publishes the abstracts of the biennial conferences of the SENS Research Foundation. Rejuvenation Research is abstracted and indexed in: According to the Journal Citation Reports, the journal has a 2017 impact factor of 3.220. MEDLINE. Current Contents/Clinical Medicine. Science Citation Index Expanded. EMBASE/Excerpta Medica. Scopus. CAB Abstracts. Strategies for Engineered Negligible Senescence. Timeline of senescence research.


deoxyribonucleic aciddouble-stranded DNAdsDNA
Deoxyribonucleic acid (DNA) is a molecule composed of two chains that coil around each other to form a double helix carrying the genetic instructions used in the growth, development, functioning, and reproduction of all known living organisms and many viruses. DNA and ribonucleic acid (RNA) are nucleic acids; alongside proteins, lipids and complex carbohydrates (polysaccharides), nucleic acids are one of the four major types of macromolecules that are essential for all known forms of life.


Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread to other parts of the body. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss and a change in bowel movements. While these symptoms may indicate cancer, they may have other causes. Over 100 types of cancers affect humans.


apoptoticprogrammed cell deathcell death
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global mRNA decay. The average adult human loses between 50 and 70 billion cells each day due to apoptosis. For an average human child between the ages of 8 to 14 year old approximately 20 to 30 billion cells die per day.

University of California, Los Angeles

UCLAUniversity of CaliforniaUniversity of California at Los Angeles
The University of California, Los Angeles (UCLA), is a public research university in Los Angeles. It became the Southern Branch of the University of California in 1919, making it the second-oldest (after UC Berkeley) undergraduate campus of the 10-campus University of California system. It offers 337 undergraduate and graduate degree programs in a wide range of disciplines. UCLA enrolls about 31,000 undergraduate and 13,000 graduate students and had 119,000 applicants for Fall 2016, including transfer applicants, the most applicants for any American university.


In chemistry and biology a cross-link is a bond that links one polymer chain to another. These links may take the form of covalent bonds or ionic bonds and the polymers can be either synthetic polymers or natural polymers (such as proteins).

Advanced glycation end-product

advanced glycation endproductadvanced glycation end-productsadvanced glycation end product
Advanced glycation end products (AGEs) are proteins or lipids that become glycated as a result of exposure to sugars. They can be a factor in aging and in the development or worsening of many degenerative diseases, such as diabetes, atherosclerosis, chronic kidney disease, and Alzheimer's disease.

United States

The United States of America (USA), commonly known as the United States (U.S. or US) or America, is a country composed of 50 states, a federal district, five major self-governing territories, and various possessions. At 3.8 million square miles (9.8 million km 2 ), the United States is the world's third or fourth largest country by total area and slightly smaller than the entire continent of Europe's 3.9 million square miles (10.1 million km 2 ). With a population of over 327 million people, the U.S. is the third most populous country. The capital is Washington, D.C., and the largest city by population is New York.

Cynthia Kenyon

Cynthia Jane Kenyon
Cynthia Jane Kenyon (February 21, 1954) is an American molecular biologist and biogerontologist known for her genetic dissection of aging in a widely used model organism, the roundworm Caenorhabditis elegans and professor at the University of California, San Francisco (UCSF).

Caleb Finch

Caleb E. Finch
He serves on the Scientific Advisory Board for Cure Alzheimer's Fund. * University of Southern California Leonard Davis School of Gerontology