As vitamin D can be synthesized in adequate amounts by most mammals exposed to sufficient sunlight, it is not an essential dietary factor, although not technically a vitamin. Instead it could be considered a hormone, with activation of the vitamin D pro-hormone resulting in the active form, calcitriol, which then produces effects via a nuclear receptor in multiple locations. Cholecalciferol is converted in the liver to calcifediol (25-hydroxycholecalciferol); ergocalciferol is converted to 25-hydroxyergocalciferol. These two vitamin D metabolites (called 25-hydroxyvitamin D or 25(OH)D) are measured in serum to determine a person's vitamin D status.
DCalciferol1,25 Dihydroxy vitamin D
deoxyribonucleic aciddouble-stranded DNAdsDNA
Eukaryotic organisms (animals, plants, fungi and protists) store most of their DNA inside the cell nucleus as nuclear DNA, and some in the mitochondria as mitochondrial DNA or in chloroplasts as chloroplast DNA. In contrast, prokaryotes (bacteria and archaea) store their DNA only in the cytoplasm, in circular chromosomes. Within eukaryotic chromosomes, chromatin proteins, such as histones, compact and organize DNA. These compacting structures guide the interactions between DNA and other proteins, helping control which parts of the DNA are transcribed. DNA was first isolated by Friedrich Miescher in 1869.
vitamin D 3 vitamin D3colecalciferol
The action of calcitriol is mediated by the vitamin D receptor, a nuclear receptor which regulates the synthesis of hundreds of proteins and is present in virtually every cell in the body. Click on icon in lower right corner to open. 7-Dehydrocholesterol is the precursor of cholecalciferol. Within the epidermal layer of skin, 7-dehydrocholesterol undergoes an electrocyclic reaction as a result of UVB light at wavelengths between 290 and 315 nm, with peak synthesis occurring between 295 and 300 nm. This results in the opening of the vitamin precursor B-ring through a conrotatory pathway making previtamin D3 (pre-cholecalciferol).
Daylight is the combination of all direct and indirect sunlight during the daytime. This includes direct sunlight, diffuse sky radiation, and (often) both of these reflected by the Earth and terrestrial objects, like landforms and buildings. Sunlight scattered or reflected by objects in outer space (that is, beyond the Earth's atmosphere) is generally not considered daylight. Thus, daylight excludes moonlight, despite it being indirect sunlight. Daytime is the period of time each day when daylight occurs. Daylight happens as Earth rotates, and either side on which the Sun shines is considered daylight.
When sunlight is plentiful and the atmospheric temperature climbs, it has been claimed that the phytoplankton of the ocean surface waters, acting as global sunshine, and therefore heat sensors, may thrive and produce more dimethyl sulfide (DMS). The DMS molecules act as cloud condensation nuclei, which produce more clouds, and thus increase the atmospheric albedo, and this feeds back to lower the temperature of the atmosphere. However, rising sea temperature has stratified the oceans, separating warm, sunlit waters from cool, nutrient-rich waters. Thus, nutrients have become the limiting factor, and plankton levels have actually fallen over the past 50 years, not risen.
Gravity and pressure within the core of the cloud generated a lot of heat as it accreted more matter from the surrounding disk, eventually triggering nuclear fusion. HD 162826 and HD 186302 are hypothesized stellar siblings of the Sun, having formed in the same molecular cloud. The Sun is about halfway through its main-sequence stage, during which nuclear fusion reactions in its core fuse hydrogen into helium. Each second, more than four million tonnes of matter are converted into energy within the Sun's core, producing neutrinos and solar radiation. At this rate, the Sun has so far converted around 100 times the mass of Earth into energy, about 0.03% of the total mass of the Sun.
sunshine hoursbright sunshinehours of bright sunshine
Sunshine duration or sunshine hours is a climatological indicator, measuring duration of sunshine in given period (usually, a day or a year) for a given location on Earth, typically expressed as an averaged value over several years. It is a general indicator of cloudiness of a location, and thus differs from insolation, which measures the total energy delivered by sunlight over a given period. Sunshine duration is usually expressed in hours per year, or in (average) hours per day. The first measure indicates the general sunniness of a location compared with other places, while the latter allows for comparison of sunshine in various seasons in the same location.
Type 4: Nuclear receptors – While they are called nuclear receptors, they are actually located in the cytoplasm and migrate to the nucleus after binding with their ligands. They are composed of a C-terminal ligand-binding region, a core DNA-binding domain (DBD) and an N-terminal domain that contains the AF1(activation function 1) region. The core region has two zinc fingers that are responsible for recognizing the DNA sequences specific to this receptor. The N terminus interacts with other cellular transcription factors in a ligand-independent manner; and, depending on these interactions, it can modify the binding/activity of the receptor.
(Nuclear Receptor Resource).
FXRfarnesoid X receptoFarnesoid X receptor (FXR)
The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4) is a nuclear receptor that is encoded by the NR1H4 gene in humans. FXR is expressed at high levels in the liver and intestine. Chenodeoxycholic acid and other bile acids are natural ligands for FXR. Similar to other nuclear receptors, when activated, FXR translocates to the cell nucleus, forms a dimer (in this case a heterodimer with RXR) and binds to hormone response elements on DNA, which up- or down-regulates the expression of certain genes.
Modern sunshine recorders use electronics and computers for precise data that do not depend on a human interpreter. Newer recorders can also measure the global and diffuse radiation. Pictures of the papers produced by a Sunlight Recorder. Komoka Sunrecorder Current Images.
In the field of molecular biology, the pregnane X receptor (PXR), also known as the steroid and xenobiotic sensing nuclear receptor (SXR) or nuclear receptor subfamily 1, group I, member 2 (NR1I2) is a protein that in humans is encoded by the NR1I2 (nuclear Receptor subfamily 1, group I, member 2) gene. PXR is a nuclear receptor whose primary function is to sense the presence of foreign toxic substances and in response up regulate the expression of proteins involved in the detoxification and clearance of these substances from the body.
transcription factorsgene transcription factortranscriptional factors
II.B.1 extracellular ligand (endocrine or paracrine)-dependent – nuclear receptors. II.B.2 intracellular ligand (autocrine)-dependent - activated by small intracellular molecules – SREBP, p53, orphan nuclear receptors. II.B.3 cell membrane receptor-dependent – second messenger signaling cascades resulting in the phosphorylation of the transcription factor. II.B.3.a resident nuclear factors – reside in the nucleus regardless of activation state – CREB, AP-1, Mef2.
The constitutive androstane receptor (CAR) also known as nuclear receptor subfamily 1, group I, member 3 is a protein that in humans is encoded by the NR1I3 gene. CAR is a member of the nuclear receptor superfamily and along with pregnane X receptor (PXR) functions as a sensor of and xenobiotic substances. In response, expression of proteins responsible for the metabolism and excretion of these substances is upregulated. Hence, CAR and PXR play a major role in the detoxification of foreign substances such as drugs.
Two classes of ER exist: nuclear estrogen receptors (ERα and ERβ), which are members of the nuclear receptor family of intracellular receptors, and membrane estrogen receptors (mERs) (GPER (GPR30), ER-X, and G q -mER), which are mostly G protein-coupled receptors. This article refers to the former (ER). Once activated by estrogen, the ER is able to translocate into the nucleus and bind to DNA to regulate the activity of different genes (i.e. it is a DNA-binding transcription factor). However, it also has additional functions independent of DNA binding.
The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor. The main function of the androgen receptor is as a DNA-binding transcription factor that regulates gene expression; however, the androgen receptor has other functions as well.
The glucocorticoid receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. Because the receptor gene is expressed in several forms, it has many different (pleiotropic) effects in different parts of the body. When glucocorticoids bind to GR, its primary mechanism of action is the regulation of gene transcription. The unbound receptor resides in the cytosol of the cell.
Tiny particles of water are densely packed and sunlight cannot penetrate far into the cloud before it is reflected out, giving a cloud its characteristic white color, especially when viewed from the top. Cloud droplets tend to scatter light efficiently, so that the intensity of the solar radiation decreases with depth into the gases. As a result, the cloud base can vary from a very light to very-dark-grey depending on the cloud's thickness and how much light is being reflected or transmitted back to the observer.
Nuclear receptor co-repressor 2, and. UBE3A. Membrane progesterone receptor. Selective progesterone receptor modulator. Phytoprogestogen.
visible lightvisiblelight source
A simple thermal source is sunlight, the radiation emitted by the chromosphere of the Sun at around 6000 K peaks in the visible region of the electromagnetic spectrum when plotted in wavelength units and roughly 44% of sunlight energy that reaches the ground is visible. Another example is incandescent light bulbs, which emit only around 10% of their energy as visible light and the remainder as infrared. A common thermal light source in history is the glowing solid particles in flames, but these also emit most of their radiation in the infrared, and only a fraction in the visible spectrum.
signaling pathwayssignaling cascadesignal transduction pathways
Intracellular receptors, such as nuclear receptors and cytoplasmic receptors, are soluble proteins localized within their respective areas. The typical ligands for nuclear receptors are non-polar hormones like the steroid hormones testosterone and progesterone and derivatives of vitamins A and D. To initiate signal transduction, the ligand must pass through the plasma membrane by passive diffusion. On binding with the receptor, the ligands pass through the nuclear membrane into the nucleus, altering gene expression.
RXRretinoid X receptor (RXR)retinoid X receptors
RXR heterodimerizes with subfamily 1 nuclear receptors including CAR, FXR, LXR, PPAR, PXR, RAR, TR, and VDR. As with other type II nuclear receptors, the RXR heterodimer in the absence of ligand is bound to hormone response elements complexed with corepressor protein. Binding of agonist ligands to RXR results in dissociation of corepressor and recruitment of coactivator protein, which, in turn, promotes transcription of the downstream target gene into mRNA and eventually protein. * Retinoic acid receptor. Retinoid X receptor alpha. Retinoid X receptor beta. Retinoid X receptor gamma.
Initially most scientists presumed that non-genomic effects were mediated by non-nuclear receptors, but now there is growing evidence for non-genomic effects mediated in the cytoplasm by the traditional nuclear receptors. For example,TR-α1 (a specific isoform of TR) has been linked to cell viability, which is hypothesized to involve a rise in cGMP concentration (through an unknown mechanism) and the corresponding activation of protein kinase G.
RARretinoic acidreceptors for retinoic acid
The retinoic acid receptor (RAR) is a type of nuclear receptor which can also act as a transcription factor that is activated by both all-trans retinoic acid and 9-cis retinoic acid. There are three retinoic acid receptors (RAR), RAR-alpha, RAR-beta, and RAR-gamma, encoded by the,, genes, respectively. Each receptor isoform has ten splice variants: four for alpha, four for beta, and two for gamma. As with other type II nuclear receptors, RAR heterodimerizes with RXR and in the absence of ligand, the RAR/RXR dimer binds to hormone response elements known as retinoic acid response elements (RAREs) complexed with corepressor protein.
These receptors belong to the nuclear receptor family of ligand-activated transcription factors. To bind their receptors, these hormones must first cross the cell membrane. They can do so because they are lipid-soluble. The combined hormone-receptor complex then moves across the nuclear membrane into the nucleus of the cell, where it binds to specific DNA sequences, regulating the expression of certain genes, and thereby increasing the levels of the proteins encoded by these genes. However, it has been shown that not all steroid receptors are located inside the cell. Some are associated with the plasma membrane.