RAC-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene.wikipedia
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PH domainpleckstrin homologyPH
The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1.
Elephant man in context of NFelephantiasisWiedemann syndrome
A single-nucleotide polymorphism in this gene causes Proteus syndrome.
In 26 of 29 patients who met strict clinical criteria for the disorder, Lindhurst et al. identified an activating mutation in AKT1 kinase in a mosaic state gene.
HSP90AA1Heat shock protein 90kDa alpha (cytosolic) member A1heat shock protein-90α
AKTIP has been shown to interact with AKT1.
MAP3K8 has been shown to interact with AKT1, CHUK, NFKB2, NFKB1, C22orf25 and TNIP2.
IKKAconserved helix-loop-helix ubiquitous kinaseIKBKA
p27p27 Kip1 p27Kip1
mammalian target of rapamycinmechanistic target of rapamycinTOR
This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 (Src homology 2-like) domains.
Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes.
MAPKAP kinase 2MK2MAPKAP kinase-2
Keratin 10 has been shown to interact with AKT1.
In addition, this protein has been reported to negatively regulate the cell survival serine-threonine kinase AKT1.
MAP2K4 has been shown to interact with FLNC, MAPK8, MAPK8IP3 and AKT1.
tuberinTuberous sclerosis complex 2tuberous sclerosis protein 2