ANKK1

ANNK1 and addictive behaviors
Ankyrin repeat and kinase domain containing 1 (ANKK1) also known as protein kinase PKK2 or sugen kinase 288 (SgK288) is an enzyme that in humans is encoded by the ANKK1 gene.wikipedia
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Ankyrin repeat

ANKANK repeatAnkA
This gene contains a single nucleotide polymorphism that causes an amino acid substitution within the 11th of 12 ankyrin repeats of ANKK1 (Glu713Lys of 765 residues).
A natural variation between glutamine and lysine at position 703 in the 11th ankyrin repeat of ANKK1, known as the TaqI A1 allele, has been credited with encouraging addictive behaviours such as obesity, alcoholism, nicotine dependency and the Eros love style while discouraging juvenile delinquency and neuroticism-anxiety.

Dopamine receptor D2

D 2 D 2 receptorDRD2
This polymorphism, which is commonly referred to Taq1A, was previously believed to be located in the promoter region of the DRD2 gene, since the polymorphism is proximal to the DRD2 gene and can influence DRD2 receptor expression.
However, the polymorphism resides in exon 8 of the ANKK1 gene.

Schizoid avoidant behavior

schizoid-avoidant behaviorSchizoid/avoidant behavior
Both have been associated with a shared genetic risk factor and the same polymorphism within the ANKK1 gene.

Enzyme

enzymologyenzymesenzymatic
Ankyrin repeat and kinase domain containing 1 (ANKK1) also known as protein kinase PKK2 or sugen kinase 288 (SgK288) is an enzyme that in humans is encoded by the ANKK1 gene.

Gene

genesnumber of genesgene sequence
Ankyrin repeat and kinase domain containing 1 (ANKK1) also known as protein kinase PKK2 or sugen kinase 288 (SgK288) is an enzyme that in humans is encoded by the ANKK1 gene.

Serine/threonine-specific protein kinase

serine/threonine kinaseserine/threonine protein kinaseprotein-serine/threonine kinase
The ANKK1 is a member of an extensive family of the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways.

Protein kinase

protein kinasestransmembranekinases
The ANKK1 is a member of an extensive family of the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways.

Signal transduction

signaling pathwayssignaling cascadesignal transduction pathways
The ANKK1 is a member of an extensive family of the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways.

Single-nucleotide polymorphism

single nucleotide polymorphismSNPSNPs
This gene contains a single nucleotide polymorphism that causes an amino acid substitution within the 11th of 12 ankyrin repeats of ANKK1 (Glu713Lys of 765 residues).

Amino acid

amino acidsresiduesresidue
This gene contains a single nucleotide polymorphism that causes an amino acid substitution within the 11th of 12 ankyrin repeats of ANKK1 (Glu713Lys of 765 residues).

Promoter (genetics)

promoterpromoterspromoter region
This polymorphism, which is commonly referred to Taq1A, was previously believed to be located in the promoter region of the DRD2 gene, since the polymorphism is proximal to the DRD2 gene and can influence DRD2 receptor expression.

Dopamine

dopaminergic systemDAdopaminergic
It is now known to be located in the coding region of the ANKK1 gene which controls the synthesis of dopamine in the brain. Dopamine (DA) is a neurotransmitter in the brain, which controls feelings of wellbeing.

Striatum

ventral striatumdorsal striatumcorpus striatum
The A1 allele is associated with increased activity of striatal L-amino acid decarboxylase.

Aromatic L-amino acid decarboxylase

DOPA decarboxylasearomatic L -amino acid decarboxylasearomatic amino acid decarboxylase
The A1 allele is associated with increased activity of striatal L-amino acid decarboxylase.

Narcissistic personality disorder

megalomanianarcissisticmegalomaniac
Given that the A1+ allele is associated with antisocial personality disorder, one may infer that the allele is also associated with narcissistic personality disorder and histrionic personality disorder.

Histrionic personality disorder

histrionichistrionic personalityhistrionics
Given that the A1+ allele is associated with antisocial personality disorder, one may infer that the allele is also associated with narcissistic personality disorder and histrionic personality disorder.

Allele

allelesallelicmultiple alleles
The A1 allele of the Taq1A polymorphism (rs1800497T), is located ≈10kb downstream of the dopamine receptor DRD2 gene.

Polymorphism (biology)

polymorphismpolymorphicmorph
The A1 allele of the Taq1A polymorphism (rs1800497T), is located ≈10kb downstream of the dopamine receptor DRD2 gene.

Dopamine receptor

dopaminedopamine receptorsdopaminergic
The A1 allele of the Taq1A polymorphism (rs1800497T), is located ≈10kb downstream of the dopamine receptor DRD2 gene.

Neurotransmitter

neurotransmittersexcitatory neurotransmitterneurotransmitter system
Dopamine (DA) is a neurotransmitter in the brain, which controls feelings of wellbeing.

Serotonin

5-HTserotonergic5-hydroxytryptamine
This sensation results from the interaction of dopamine and other neurotransmitters such as serotonin, the opioids, and other brain chemicals.

Opioid

opioidsopioid-induced constipationopioid analgesic
This sensation results from the interaction of dopamine and other neurotransmitters such as serotonin, the opioids, and other brain chemicals.