ANKS1A

Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A), also known as ODIN, is a protein that in humans is encoded by the ANKS1A gene on chromosome 6.wikipedia
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Sterile alpha motif

SAMSAM domaintandem sterile alpha motif (SAM)
ODIN is a member of the ankyrin repeat and sterile alpha motif domain-containing (ANKS) family and contains 6 ankyrin repeats, 1 phosphotyrosine binding (PTD) domain, and 2 tandem sterile alpha motif (SAM) domains.
ANKS1A; ANKS1B; ANKS3; ANKS4B; ANKS6; BFAR; BICC1; CASKIN1;

Protein

proteinsproteinaceousstructural proteins
Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A), also known as ODIN, is a protein that in humans is encoded by the ANKS1A gene on chromosome 6.

Gene

genesnumber of genesgene sequence
Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A), also known as ODIN, is a protein that in humans is encoded by the ANKS1A gene on chromosome 6.

Chromosome 6

chr.66Chromosome 6 (human)
Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A), also known as ODIN, is a protein that in humans is encoded by the ANKS1A gene on chromosome 6.

Epidermal growth factor receptor

EGFREGF receptorEGFR inhibitor
ODIN is known to regulate the epidermal growth factor receptor (EGFR) and EphA receptor signaling pathways.

Ephrin receptor

Eph receptorEphrinEphrin receptors
ODIN is known to regulate the epidermal growth factor receptor (EGFR) and EphA receptor signaling pathways.

Src family kinase

SRCSrc family kinasesSrc-family kinase
As a Src family kinase target, ODIN has been implicated in the development of cancer.

Cancer

cancersmalignanciescancerous
As a Src family kinase target, ODIN has been implicated in the development of cancer.

Single-nucleotide polymorphism

single nucleotide polymorphismSNPSNPs
The ANKS1A gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.

Coronary artery disease

coronary heart diseaseischemic heart diseaseischaemic heart disease
The ANKS1A gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.

Exon

exonsexons.coding region
The ANKS1A gene resides on chromosome 6 at the band 6p21.31 and includes 29 exons.

Protein isoform

isoformsisoformglycoform
This gene produces 2 isoforms through alternative splicing.

Alternative splicing

alternatively splicedtranscript variantssplice variant
This gene produces 2 isoforms through alternative splicing.

Ankyrin

ankyrin repeatsANK2ankyrin repeats domain
ODIN is a member of the ankyrin repeat and sterile alpha motif domain-containing (ANKS) family and contains 6 ankyrin repeats, 1 phosphotyrosine binding (PTD) domain, and 2 tandem sterile alpha motif (SAM) domains.

Phosphotyrosine-binding domain

PTB domainphosphotyrosine-bindingPTB
ODIN is a member of the ankyrin repeat and sterile alpha motif domain-containing (ANKS) family and contains 6 ankyrin repeats, 1 phosphotyrosine binding (PTD) domain, and 2 tandem sterile alpha motif (SAM) domains.

EPH receptor A2

EPHA2
The first SAM domain binds to the SAM domain of the EphA2 receptor by adopting a mid-loop/end-helix conformation and may regulate EphA2 endocytosis.

Endocytosis

endocytosedendocyticinternalization
The first SAM domain binds to the SAM domain of the EphA2 receptor by adopting a mid-loop/end-helix conformation and may regulate EphA2 endocytosis.

Heart

cardiachuman heartapex of the heart
ODIN is widely expressed in tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Brain

brain functionmammalian braincerebral
ODIN is widely expressed in tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Placenta

placental barrierchorioallantoic placentaafterbirth
ODIN is widely expressed in tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Lung

lungspulmonaryright lung
ODIN is widely expressed in tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Liver

hepaticliver protein synthesislivers
ODIN is widely expressed in tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Skeletal muscle

skeletal musclesskeletalmuscle
ODIN is widely expressed in tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Kidney

kidneysrenalkidney disorder
ODIN is widely expressed in tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Pancreas

pancreaticexocrine pancreaspancreatic development
ODIN is widely expressed in tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.