Activator (genetics)

activatortranscriptional activatoractivatorstranscriptional activatorstranscription activatortranscription activatorsactivationActivator proteinactivator proteinstranscriptional activation
A transcriptional activator is a protein (transcription factor) that increases gene transcription of a gene or set of genes.wikipedia
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Transcription factor

transcription factorsgene transcription factortranscriptional factors
A transcriptional activator is a protein (transcription factor) that increases gene transcription of a gene or set of genes.
TFs work alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme that performs the transcription of genetic information from DNA to RNA) to specific genes.

Enhancer (genetics)

enhancerenhancersgene enhancer
Most activators are DNA-binding proteins that bind to enhancers or promoter-proximal elements.
In genetics, an enhancer is a short (50–1500 bp) region of DNA that can be bound by proteins (activators) to increase the likelihood that transcription of a particular gene will occur.

Transcription (biology)

transcriptiontranscribedtranscriptional
A transcriptional activator is a protein (transcription factor) that increases gene transcription of a gene or set of genes.
Transcription initiation is regulated by additional proteins, known as activators and repressors, and, in some cases, associated coactivators or corepressors, which modulate formation and function of the transcription initiation complex.

Catabolite activator protein

CAPCAP (catabolite gene activator protein)CRP
The catabolite activator protein (CAP; also known as cAMP receptor protein, CRP) activates transcription at the lac operon of the bacterium Escherichia coli.
Catabolite activator protein (CAP; also known as cAMP receptor protein, CRP) is a trans-acting transcriptional activator that exists as a homodimer in solution.

General transcription factor

transcription factorsbasal transcriptionbasal transcription factor
Most activators function by binding sequence-specifically to a DNA site located in or near a promoter and making protein–protein interactions with the general transcription machinery (RNA polymerase and general transcription factors), thereby facilitating the binding of the general transcription machinery to the promoter.
A transcription factor is a protein that binds to specific DNA sequences (enhancer or promoter), either alone or with other proteins in a complex, to control the rate of transcription of genetic information from DNA to messenger RNA by promoting (serving as an activator) or blocking (serving as a repressor) the recruitment of RNA polymerase.

Coactivator (genetics)

coactivatorcoactivatorsco-activator
A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a gene or set of genes.

Promoter (genetics)

promoterpromoterspromoter region
Most activators are DNA-binding proteins that bind to enhancers or promoter-proximal elements. Most activators function by binding sequence-specifically to a DNA site located in or near a promoter and making protein–protein interactions with the general transcription machinery (RNA polymerase and general transcription factors), thereby facilitating the binding of the general transcription machinery to the promoter.
These transcription factors have specific activator or repressor sequences of corresponding nucleotides that attach to specific promoters and regulate gene expression.

Lac operon

lac'' operonlacZlac
The catabolite activator protein (CAP; also known as cAMP receptor protein, CRP) activates transcription at the lac operon of the bacterium Escherichia coli.
The lac gene and its derivatives are amenable to use as a reporter gene in a number of bacterial-based selection techniques such as two hybrid analysis, in which the successful binding of a transcriptional activator to a specific promoter sequence must be determined.

Operon

operatoroperonsOperator (biology)
5 The regulators of a given operon, including repressors, corepressors, and activators, are not necessarily coded for by that operon.

Regulation of gene expression

gene regulationregulationregulatory
Activators enhance the interaction between RNA polymerase and a particular promoter, encouraging the expression of the gene.

DNA-binding protein

DNA binding proteinprotein-DNA interactionDNA-binding
Most activators are DNA-binding proteins that bind to enhancers or promoter-proximal elements.

RNA polymerase

DNA-dependent RNA polymeraseRNAPRNA polymerases
Most activators function by binding sequence-specifically to a DNA site located in or near a promoter and making protein–protein interactions with the general transcription machinery (RNA polymerase and general transcription factors), thereby facilitating the binding of the general transcription machinery to the promoter.

CAMP receptor protein

CRPAMP-CRPcAMP receptor family
The catabolite activator protein (CAP; also known as cAMP receptor protein, CRP) activates transcription at the lac operon of the bacterium Escherichia coli.

Escherichia coli

E. coliE.coliE-coli
The catabolite activator protein (CAP; also known as cAMP receptor protein, CRP) activates transcription at the lac operon of the bacterium Escherichia coli.

Cyclic adenosine monophosphate

cAMPcyclic AMP3',5'-cyclic AMP
Cyclic adenosine monophosphate (cAMP) is produced during glucose starvation, binds to CAP, causes a conformational change that allows CAP to bind to a DNA site located adjacent to the lac promoter.

Estrogen receptor alpha

ERαESR1estrogen receptor α
The estrogen receptor (ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription.

Protein inhibitor of activated STAT

PIASprotein inhibitors of activated STAT
PIAS proteins act as transcriptional co-regulators with at least 60 different proteins in order to either activate or repress transcription.

Zinc finger chimera

selection of zinc fingers during by display
The effector domain may be a transcriptional activator (A) or repressor (R), a methylation domain (M) or a nuclease (N).

APC/C activator protein CDH1

Cdh1
Functioning as an activator of the APC/C, Cdh1 regulates the activity and substrate specificity of this ubiquitin E3-ligase.

DCas9 activation system

dCas9CRISPR activation (CRISPRa)CRISPRa
CRISPR activation (CRISPRa) is one type of CRISPR tool that use modified versions of dCas9, a mutation of Cas9 without endonuclease activity, with added transcriptional activators on dCas9 or the guide RNAs (gRNAs).

ARID2

ARID2 is a subunit of the PBAF chromatin-remodeling complex, which facilitates ligand-dependent transcriptional activation by nuclear receptors.

CLOCK

CLKclock genesclock gene
Research shows that the CLOCK gene plays a major role as an activator of downstream elements in the pathway critical to the generation of circadian rhythms.