The succinate dehydrogenase complex showing several cofactors, including flavin, iron–sulfur centers, and heme.
Bacillus stearothermophilus adenylate kinase
A simple [Fe2S2] cluster containing two iron atoms and two sulfur atoms, coordinated by four protein cysteine residues.
PDB image 3HPQ showing the ADK enzyme skeleton in cartoon and the key residues as sticks and labeled according to their placement in E. coli, crystallized with Ap5A inhibitor.
The redox reactions of nicotinamide adenine dinucleotide.
Residues of ADKE. coli involved in substrate binding
Describes the generic kinetic cycle of the ADK enzyme family. Ternary complex is labeled.

A magnesium cofactor is also required, essential for increasing the electrophilicity of the phosphate on AMP, though this magnesium ion is only held in the active pocket by electrostatic interactions and dissociates easily.

- Adenylate kinase

Calcium is another special case, in that it is required as a component of the human diet, and it is needed for the full activity of many enzymes, such as nitric oxide synthase, protein phosphatases, and adenylate kinase, but calcium activates these enzymes in allosteric regulation, often binding to these enzymes in a complex with calmodulin.

- Cofactor (biochemistry)
The succinate dehydrogenase complex showing several cofactors, including flavin, iron–sulfur centers, and heme.

0 related topics with Alpha

Overall