Adrenarche

Adrenarche is an early stage in sexual maturation that happens in some higher primates and in humans typically peaks at around 10 to 14 years of age and is eventually involved in the development of pubic hair, body odor, skin oiliness, and acne.wikipedia
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Dehydroepiandrosterone

DHEAAndrostenolone5-Dehydroepiandrosterone
During adrenarche the adrenal glands secrete increased levels of weak adrenal androgens, including dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), and androstenedione (A4), but without increased cortisol levels.
DHEA and other adrenal androgens such as androstenedione, although relatively weak androgens, are responsible for the androgenic effects of adrenarche, such as early pubic and axillary hair growth, adult-type body odor, increased oiliness of hair and skin, and mild acne.

Androstenedione

4-androstenedioneandrost-4-ene-3,17-dioneandrostendione
During adrenarche the adrenal glands secrete increased levels of weak adrenal androgens, including dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), and androstenedione (A4), but without increased cortisol levels.
In children aged 6 to 8 years old, there is a rise in androstenedione secretion along with DHEA during adrenarche.

Puberty

pubescentpubescencesexual development
Adrenarche is a process related to puberty, but distinct from hypothalamic–pituitary–gonadal axis (HPG axis) maturation and function.
Puberty is preceded by adrenarche, marking an increase of adrenal androgen production between ages 6–10.

Adrenal gland

adrenal glandsadrenalsuprarenal gland
During adrenarche the adrenal glands secrete increased levels of weak adrenal androgens, including dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), and androstenedione (A4), but without increased cortisol levels.
These changes are part of a process called adrenarche, which has only been described in humans and some other primates.

Dehydroepiandrosterone sulfate

DHEA sulfateDHEA-SDHEAS
During adrenarche the adrenal glands secrete increased levels of weak adrenal androgens, including dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), and androstenedione (A4), but without increased cortisol levels.
They remain low during childhood until adrenarche around 6 to 8 years of age, at which point they markedly increase, eventually peaking at around 20 to 30 years of age.

Acne

acne vulgariscystic acneAcne scarring
Adrenarche is an early stage in sexual maturation that happens in some higher primates and in humans typically peaks at around 10 to 14 years of age and is eventually involved in the development of pubic hair, body odor, skin oiliness, and acne.
Higher amounts of DHEA-S are secreted during adrenarche (a stage of puberty), and this leads to an increase in sebum production.

Adrenal cortex

adrenocorticalcortexadrenocortical cells
Adrenarche is the result of the development of a new zone of the adrenal cortex, the zona reticularis.

Pubarche

beginningdevelopment of pubic hairpubic hair
Parents and many physicians often infer (incorrectly) the onset of puberty from the first appearance of pubic hair (termed pubarche).
Premature adrenarche is the most common cause of premature pubarche.

Adrenopause

Levels of adrenal androgens start to increase around age 7 or 8 years (adrenarche), peak in early adulthood around age 20 to 25 years, and decrease at a rate of approximately 2% per year thereafter, eventually reaching levels of 10 to 20% of those of young adults by age 80 years.

Sexual maturity

sexually maturemature sexuallymaturity
Adrenarche is an early stage in sexual maturation that happens in some higher primates and in humans typically peaks at around 10 to 14 years of age and is eventually involved in the development of pubic hair, body odor, skin oiliness, and acne.

Primate

primatesnon-human primatesnon-human primate
Adrenarche is an early stage in sexual maturation that happens in some higher primates and in humans typically peaks at around 10 to 14 years of age and is eventually involved in the development of pubic hair, body odor, skin oiliness, and acne.

Human

humanshuman beinghuman beings
Adrenarche is an early stage in sexual maturation that happens in some higher primates and in humans typically peaks at around 10 to 14 years of age and is eventually involved in the development of pubic hair, body odor, skin oiliness, and acne.

Pubic hair

pubicpubic areapubes
Adrenarche is an early stage in sexual maturation that happens in some higher primates and in humans typically peaks at around 10 to 14 years of age and is eventually involved in the development of pubic hair, body odor, skin oiliness, and acne. Parents and many physicians often infer (incorrectly) the onset of puberty from the first appearance of pubic hair (termed pubarche). The principal physical consequences of adrenarche are androgen effects, especially pubic hair (in which Tanner stage 2 becomes Tanner stage 3) and the change of sweat composition that produces adult body odor.

Body odor

body odourB.O.odor
Adrenarche is an early stage in sexual maturation that happens in some higher primates and in humans typically peaks at around 10 to 14 years of age and is eventually involved in the development of pubic hair, body odor, skin oiliness, and acne. The principal physical consequences of adrenarche are androgen effects, especially pubic hair (in which Tanner stage 2 becomes Tanner stage 3) and the change of sweat composition that produces adult body odor.

Human skin

skinoily skinskin aging
Adrenarche is an early stage in sexual maturation that happens in some higher primates and in humans typically peaks at around 10 to 14 years of age and is eventually involved in the development of pubic hair, body odor, skin oiliness, and acne.

Adrenal steroid

adrenal androgen
During adrenarche the adrenal glands secrete increased levels of weak adrenal androgens, including dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), and androstenedione (A4), but without increased cortisol levels.

Cortisol

stress hormonestress hormoneshydrocortisone
During adrenarche the adrenal glands secrete increased levels of weak adrenal androgens, including dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), and androstenedione (A4), but without increased cortisol levels. Levels of corticosteroids like cortisol do not change with adrenarche.

Zona reticularis

zona reticulosa
Adrenarche is the result of the development of a new zone of the adrenal cortex, the zona reticularis.

Hypothalamic–pituitary–gonadal axis

hypothalamic-pituitary-gonadal axisHPG axisHPG
Adrenarche is a process related to puberty, but distinct from hypothalamic–pituitary–gonadal axis (HPG axis) maturation and function.

Corticosteroid

corticosteroidssteroidssteroid
Levels of corticosteroids like cortisol do not change with adrenarche.

Insulin

insulin geneINShuman insulin
A third avenue of research is pursuing a possible relationship with either fetal or childhood body mass and related signals such as insulin and leptin.

Leptin

leptin resistanceLEPlectin
A third avenue of research is pursuing a possible relationship with either fetal or childhood body mass and related signals such as insulin and leptin.

Intrauterine growth restriction

intrauterine growth retardationfetal growth restrictionIUGR
Many children born small for gestational age (SGA) because of intrauterine growth restriction (IUGR) have an earlier onset of adrenarche, which raises the possibility that timing of adrenarche may be affected by physiological programming in infancy.

Obesity

obesemorbidly obeseoverweight
Adrenarche also occurs prematurely in many children who are overweight, suggesting a possible relationship with body mass or adiposity signals.

Androgen

androgensandrogenicAndrogenic steroid
The principal physical consequences of adrenarche are androgen effects, especially pubic hair (in which Tanner stage 2 becomes Tanner stage 3) and the change of sweat composition that produces adult body odor.