Alkylating antineoplastic agent

alkylating agentalkylating agentsalkylatingAlkylating antineoplastic agentsalkylating antineoplasticalkylating drugantineoplastic agents, alkylatingcertain cancer chemotherapeutic medicinesDNA alkylating agents
An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (C n H 2n+1 ) to DNA.wikipedia
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Alkylation

alkylating agentalkylatealkylated
An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (C n H 2n+1 ) to DNA.
Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents.

Alkyl

alkyl groupalkyl groupsheptyl
An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (C n H 2n+1 ) to DNA.
Alkylating antineoplastic agents are a class of compounds that are used to treat cancer.

Cyclophosphamide

(C)'''yclophosphamidealdophosphamideCytoxan
Some of the substances require conversion into active substances in vivo (e.g., cyclophosphamide).
Cyclophosphamide is in the alkylating agent and nitrogen mustard family of medications.

Busulfan

1,4-Butanediol dimethanesulfonateBusulphanMyleran
Busulfan is an example of a dialkylating agent: it is the methanesulfonate diester of 1,4-butanediol.
Busulfan is a cell cycle non-specific alkylating antineoplastic agent, in the class of alkyl sulfonates.

Cancer

cancersmalignanciescancerous
Since cancer cells, in general, proliferate faster and with less error-correcting than healthy cells, cancer cells are more sensitive to DNA damage—such as being alkylated.
The term encompasses a variety of drugs, which are divided into broad categories such as alkylating agents and antimetabolites.

Melphalan

Alkeranmelphalan hydrochloride
Examples include melphalan and chlorambucil.
Melphalan belongs to the class of nitrogen mustard alkylating agents.

Labile cell

cells that divide frequentlyconstantly dividing cellscontinuously dividing cells
However, they are also toxic to normal cells (cytotoxic), particularly cells that divide frequently, such as those in the gastrointestinal tract, bone marrow, testicles and ovaries, which can cause loss of fertility.
In addition, cytotoxic drugs, such as alkylating antineoplastic agents, used in treatment of cancer, work by inhibiting the proliferation of dividing cells, with the malignant cells as the desired target.

Chlorambucil

Leukeran
Examples include melphalan and chlorambucil.
Chlorambucil is in the alkylating agent family of medications.

Carcinogen

carcinogeniccarcinogenscarcinogenicity
Most of the alkylating agents are also carcinogenic.

Lomustine

CCNU1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosoureaCeeBU
Lomustine (INN); abbreviated as CCNU; original brand name CeeNU, now marketed as Gleostine) is an alkylating nitrosourea compound used in chemotherapy.

Carmustine

BCNUGliadel WaferBCNU (carmustine)
It is a nitrogen mustard β-chloro-nitrosourea compound used as an alkylating agent.

Nitrosourea

nitrosoureasnitrosourea compound
Nitrosourea compounds are DNA alkylating agents and are often used in chemotherapy.

Chlormethine

mechlorethaminemustineBis(2-chloroethyl)methylamine
Use of methyl bis (B-chloroethyl)emine hydrochloride (mechlorethamine, mustine) and tris (B-chloroethy) amine hydrochloride for Hodgkin's disease lymphosarcoma, leukemia, and other malignancies resulted in striking but temporary dissolution of tumor masses.
Mechlorethamine belongs to the group of nitrogen mustard alkylating agents.

Uramustine

Uracil mustard
Uramustine (INN) or uracil mustard is a chemotherapy drug which belongs to the class of alkylating agents.

Ifosfamide

(I)'''fosfamideIFEXIsophosphamide
Ifosfamide is in the alkylating agent and nitrogen mustard family of medications.

Temozolomide

Temodarchemotherapytemozolamide
It is an alkylating agent used as a treatment of some brain cancers; as a second-line treatment for astrocytoma and a first-line treatment for glioblastoma multiforme.

Altretamine

HexamethylmelamineHexalen
It is indicated for use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with cisplatin and/or alkylating agent-based combination.

Streptozotocin

streptozocinZanosar
As with other alkylating agents in the nitrosourea class, it is toxic to cells by causing damage to the DNA, though other mechanisms may also contribute.

Alkyl sulfonate

Alkyl sulfonatesalkylsulfonate
They act as alkylating agents, some of them are used as alkylating antineoplastic agents in the treatment of cancer, e.g. Busulfan.

Procarbazine

(P)'''rocarbazineMatulaneProcarbazine hydrochloride
Procarbazine is in the alkylating agents family of medication.

Dacarbazine

(D)'''acarbazineDtic-Dome
Dacarbazine is in the alkylating agent and purine analog families of medication.

Platinum-based antineoplastic

platinum-based chemotherapyplatin therapyplatins
Platinum-based chemotherapeutic drugs (termed platinum analogues) act in a similar manner.
Platinum-based antineoplastic agents are sometimes described as "alkylating-like" due to similar effects as alkylating antineoplastic agents, although they do not have an alkyl group.

DNA

deoxyribonucleic aciddouble-stranded DNAdsDNA
An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (C n H 2n+1 ) to DNA.

Guanine

GG'''uanineGG
The alkyl group is attached to the guanine base of DNA, at the number 7 nitrogen atom of the purine ring.