Amarogentin

Amarogentin is a chemical compound found in gentian (Gentiana lutea) or in Swertia chirata.wikipedia
15 Related Articles

Iridoid

iridoidssecoiridoidsecoiridoids
The bitter principles of gentian root are secoiridoid glycosides amarogentin and gentiopicrin.
Cleavage of a bond in the cyclopentane ring gives rise to a subclass known as secoiridoids, such as oleuropein and amarogentin.

Gentiana lutea

great yellow gentianyellow gentiangentian
Amarogentin is a chemical compound found in gentian (Gentiana lutea) or in Swertia chirata.
The bitter principles of gentian root are secoiridoid glycosides amarogentin and gentiopicrin.

Taste

sourbittergustatory
The former is one of the most bitter natural compounds known and is used as a scientific basis for measuring bitterness.
The most bitter natural substance is amarogentin a compound present in the roots of the plant gentiana lutea and the most bitter substance known is the synthetic chemical denatonium, which has an index of 1,000.

Swertia

Swertia japonicaSwertia chirataSwertia chirayita
Amarogentin is a chemical compound found in gentian (Gentiana lutea) or in Swertia chirata.

Glycoside

glycosidescyanogenic glycosidescyanogenic glycoside
The bitter principles of gentian root are secoiridoid glycosides amarogentin and gentiopicrin.

Taste receptor

Taste2bitter taste receptorstaste cells
In humans, it activates the bitter taste receptor hTAS2R50.

TAS2R50

hTAS2R50
In humans, it activates the bitter taste receptor hTAS2R50.

Polyketide

polyketidespolyketide synthasespolyketide synthesis
The biphenylcarboxylic acid moiety is biosynthesized by a polyketide-type pathway, with three units of acetyl-CoA and one unit of 3-hydroxybenzoyl-CoA, this being formed from an early shikimate pathway intermediate and not via cinnamic or benzoic acid.

Acetyl-CoA

acetyl CoAacetyl coenzyme Aacetyl-coenzyme A
The biphenylcarboxylic acid moiety is biosynthesized by a polyketide-type pathway, with three units of acetyl-CoA and one unit of 3-hydroxybenzoyl-CoA, this being formed from an early shikimate pathway intermediate and not via cinnamic or benzoic acid.

Shikimate pathway

shikimic acid pathwaypathwayShikimate acid pathway
The biphenylcarboxylic acid moiety is biosynthesized by a polyketide-type pathway, with three units of acetyl-CoA and one unit of 3-hydroxybenzoyl-CoA, this being formed from an early shikimate pathway intermediate and not via cinnamic or benzoic acid.

Leishmaniasis

Mucocutaneous leishmaniasisantileishmanialDum-dum fever
It also shows an antileishmanial activity in animal models being an inhibitor of topoisomerase I.

Model organism

animal modelmouse modelanimal models
It also shows an antileishmanial activity in animal models being an inhibitor of topoisomerase I.

Topoisomerase inhibitor

inhibitorsDNA topoisomerase II inhibitorsinhibitor
It also shows an antileishmanial activity in animal models being an inhibitor of topoisomerase I.

Homoeriodictyol

Homoeriodictyol Sodium salt elicited the most potent bitter-masking activity by reducing from 10 to 40% the bitterness of salicin, amarogentin, paracetamol and quinine.

Denatonium