A report on Anterograde amnesia, Amnesia and Temporal lobe

Hippocampus (brain)
Amnesie
Lobes of the human brain (temporal lobe is shown in green)
Animation showing the position of the human left temporal lobe

In neurology, anterograde amnesia is a loss of the ability to create new memories after the event that caused amnesia, leading to a partial or complete inability to recall the recent past, while long-term memories from before the event remain intact.

- Anterograde amnesia

There are two main types of amnesia: retrograde amnesia and anterograde amnesia.

- Amnesia

To a large degree, anterograde amnesia remains a mysterious ailment because the precise mechanism of storing memories is not yet well understood, although it is known that the regions of the brain involved are certain sites in the temporal cortex, especially in the hippocampus and nearby subcortical regions.

- Anterograde amnesia

Case studies also show that amnesia is typically associated with damage to the medial temporal lobe.

- Amnesia

The medial temporal lobes include the hippocampi, which are essential for memory storage, therefore damage to this area can result in impairment in new memory formation leading to permanent or temporary anterograde amnesia.

- Temporal lobe

Amnesia, Korsakoff syndrome, Klüver–Bucy syndrome

- Temporal lobe
Hippocampus (brain)

3 related topics with Alpha

Overall
Humans have two hippocampi, one in each hemisphere of the brain. They are located in the medial temporal lobes of the cerebrum. In this lateral view of the human brain, the frontal lobe is at the left, the occipital lobe at the right, and the temporal and parietal lobes have largely been removed to reveal one of the hippocampi underneath.

Hippocampus

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Major component of the brain of humans and other vertebrates.

Major component of the brain of humans and other vertebrates.

Humans have two hippocampi, one in each hemisphere of the brain. They are located in the medial temporal lobes of the cerebrum. In this lateral view of the human brain, the frontal lobe is at the left, the occipital lobe at the right, and the temporal and parietal lobes have largely been removed to reveal one of the hippocampi underneath.
Image 1: The human hippocampus and fornix (left) compared with a seahorse (right)
Image 2: Cross-section of cerebral hemisphere showing structure and location of hippocampus
Image 3: Coronal section of the brain of a macaque monkey, showing hippocampus (circled)
Image 4: Basic circuit of the hippocampus, as drawn by Cajal DG: dentate gyrus. Sub: subiculum. EC: entorhinal cortex
Image 5: Hippocampal location and regions
Rats and cognitive maps
Image 6: Spatial firing patterns of 8 place cells recorded from the CA1 layer of a rat. The rat ran back and forth along an elevated track, stopping at each end to eat a small food reward. Dots indicate positions where action potentials were recorded, with color indicating which neuron emitted that action potential.
Image 7: Examples of rat hippocampal EEG and CA1 neural activity in the theta (awake/behaving) and LIA (slow-wave sleep) modes. Each plot shows 20 seconds of data, with a hippocampal EEG trace at the top, spike rasters from 40 simultaneously recorded CA1 pyramidal cells in the middle (each raster line represents a different cell), and a plot of running speed at the bottom. The top plot represents a time period during which the rat was actively searching for scattered food pellets. For the bottom plot the rat was asleep.
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Image 9: An EEG showing epilepsy right-hippocampal seizure onset
Image 10: An EEG showing epilepsy left-hippocampal seizure onset
Image 11: Drawing by Italian pathologist Camillo Golgi of a hippocampus stained using the silver nitrate method
thumb|Hippocampus highlighted in green on coronal T1 MRI images
thumb|Hippocampus highlighted in green on sagittal T1 MRI images
thumb|Hippocampus highlighted in green on transversal T1 MRI images

People with extensive, bilateral hippocampal damage may experience anterograde amnesia: the inability to form and retain new memories.

This ridge can also be seen as an inward fold of the archicortex into the medial temporal lobe.

It is apparent that complete amnesia occurs only when both the hippocampus and the parahippocampus are damaged.

Long-term memory

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Stage of the Atkinson–Shiffrin memory model in which informative knowledge is held indefinitely.

Stage of the Atkinson–Shiffrin memory model in which informative knowledge is held indefinitely.

Research by Meulemans and Van der Linden (2003) found that amnesiac patients with damage to the medial temporal lobe performed more poorly on explicit learning tests than did healthy controls.

His subsequent total anterograde amnesia and partial retrograde amnesia provided the first evidence for the localization of memory function, and further clarified the differences between declarative and procedural memory.

Episodic memory

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Memory of everyday events that can be explicitly stated or conjured.

Memory of everyday events that can be explicitly stated or conjured.

The formation of new episodic memories requires the medial temporal lobe, a structure that includes the hippocampus.

For example, anterograde amnesia, from damage of the medial temporal lobe, is an impairment of declarative memory that affects both episodic and semantic memory operations.

The label "amnesia" is most often given to patients with deficits in episodic memory.