A report on Cocaine and Anesthetic

Leaves of the coca plant (Erythroxylum novogranatense var. Novogranatense), from which cocaine, a naturally occurring local anesthetic, is derived.
Cocaine hydrochloride
Chemical structure of isoflurane, widely used for inhalational anesthesia.
Lines of cocaine prepared for snorting
A 2010 study ranking various illegal and legal drugs based on statements by drug-harm experts. Crack cocaine and cocaine was found to be the third and fifth overall most dangerous drugs respectively.
Side effects of chronic cocaine use
A pile of cocaine hydrochloride
A piece of compressed cocaine powder
A woman smoking crack cocaine
"Rocks" of crack cocaine
Biological source of cocaine molecule in the context of the tropane class of molecules. The biological source of each tropane alkaloid is indicated by species, and below that a phylogenetic map is provided.
Biosynthesis of N-methyl-pyrrolinium cation
Biosynthesis of cocaine
Robinson biosynthesis of tropane
Reduction of tropinone
Coca leaf in Bolivia
"Cocaine toothache drops", 1885 advertisement of cocaine for dental pain in children
Advertisement in the January 1896 issue of McClure's Magazine for Burnett's Cocaine "for the hair".
Pope Leo XIII purportedly carried a hip flask of the coca-treated Vin Mariani with him, and awarded a Vatican gold medal to Angelo Mariani.
In this 1904 advice column from the Tacoma Times, "Madame Falloppe" recommended that cold sores be treated with a solution of borax, cocaine, and morphine.
Women purchase cocaine capsules in Berlin, 1929
D.C. Mayor Marion Barry captured on a surveillance camera smoking crack cocaine during a sting operation by the FBI and D.C. Police.
Drug overdoses killed more than 70,200 Americans in 2017, with cocaine overdoses making up 13,942 of those deaths.
United States CBP police inspect a seized shipment of cocaine
The U.S. Coast Guard in Miami offloading confiscated cocaine
Cocaine smuggled in a charango, 2008
Cocaine adulterated with fruit flavoring
Opioid involvement in cocaine overdose deaths. The green line is cocaine and any opioid (top line in 2017). The gray line is cocaine without any opioids (bottom line in 2017). The yellow line is cocaine and other (middle line in 2017).<ref name=NIDA-deaths>{{cite web | url = https://www.drugabuse.gov/related-topics/trends-statistics/overdose-death-rates | title = Overdose Death Rates | archive-url = https://web.archive.org/web/20151128091723/https://www.drugabuse.gov/related-topics/trends-statistics/overdose-death-rates| archive-date=28 November 2015 | work =  By National Institute on Drug Abuse (NIDA) }}</ref>
Delphic analysis regarding 20 popular recreational drugs based on expert opinion. Cocaine was ranked the 2nd in dependence and physical harm and 3rd in social harm.<ref name="Lancet">{{cite journal|vauthors = Nutt D, King LA, Saulsbury W, Blakemore C|title = Development of a rational scale to assess the harm of drugs of potential misuse|journal = Lancet|volume = 369|issue = 9566|pages = 1047–53|date = March 2007|pmid = 17382831|doi = 10.1016/S0140-6736(07)60464-4|s2cid = 5903121|author-link4 = Colin Blakemore|author-link1 = David Nutt }}</ref>
Bottle of cocaine solution, Germany, circa 1915

Ester local anesthetics (such as procaine, amethocaine, cocaine, benzocaine, tetracaine) are generally unstable in solution and fast-acting, are rapidly metabolised by cholinesterases in the blood plasma and liver, and more commonly induce allergic reactions.

- Anesthetic

Topical cocaine is sometimes used as a local numbing agent and vasoconstrictor to help control pain and bleeding with surgery of the nose, mouth, throat or lacrimal duct.

- Cocaine

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