Angiotensin II receptor blocker

angiotensin II receptor antagonistangiotensin receptor blockersangiotensin receptor blockerangiotensin II receptor antagonistsARBsAng II antagonistsartanangiotensin II antagonists (ARBs)angiotensin II receptor blockersangiotensin ii type 1 receptor blockers
Angiotensin II receptor blockers (ARBs), also known as angiotensin II receptor antagonists, AT 1 receptor antagonists or sartans, are a group of pharmaceuticals that modulate the renin–angiotensin system.wikipedia
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Antihypertensive drug

antihypertensiveantihypertensivesantihypertensive agent
ARBs and the similar-attributed ACE inhibitors are both indicated as the first-line antihypertensives in patients developing hypertension along the left-sided heart failure.
Among the most important and most widely used medications are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.

Diabetic nephropathy

diabetic kidney diseasenephropathydiabetic nephropathies
Their main uses are in the treatment of hypertension (high blood pressure), diabetic nephropathy (kidney damage due to diabetes) and congestive heart failure.
Treatment with an angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB), which dilates the arteriole exiting the glomerulus, thus reducing the blood pressure within the glomerular capillaries, which may slow (but not stop) progression of the disease.

Candesartan

Candesartan cilexetilAtacandBlopress
More recently, they have been used for the treatment of heart failure in patients intolerant of ACE inhibitor therapy, in particular candesartan. Other ARBs include candesartan (Atacand), telmisartan (Micardis), and Valsartan (Diovan), fimasartan (Kanarb). Candesartan is used experimentally in preventive treatment of migraine. Losartan, irbesartan, olmesartan, candesartan, valsartan, fimasartan and azilsartan include the tetrazole group (a ring with four nitrogen and one carbon).
Candesartan is an angiotensin receptor blocker used mainly for the treatment of high blood pressure and congestive heart failure.

Heart failure

congestive heart failurecardiac failurechronic heart failure
ARBs and the similar-attributed ACE inhibitors are both indicated as the first-line antihypertensives in patients developing hypertension along the left-sided heart failure. Their main uses are in the treatment of hypertension (high blood pressure), diabetic nephropathy (kidney damage due to diabetes) and congestive heart failure. More recently, they have been used for the treatment of heart failure in patients intolerant of ACE inhibitor therapy, in particular candesartan. ARB inhibitors, although have protective effects against developing kidney diseases for patients with diabetes and previously hypertension without administration of ARBs, may worsen kidney functions such as causing further reduction of glomerular filtration rate associated with rise of serum creatinine in patients suffering practically clinical or already clinically present proteinuria, renal artery stenosis, hypertensive nephrosclerosis, heart failure, polycystic kidney disease, chronic kidney disease, interstitial fibrosis, focal segmental glomerulosclerosis, or any conditions such as ARBs-treated but still clinically hypertension that lead to abnormal narrowing of blood vessels to the kidney that interrupts oxygen and nutrients supply to the organ.
In those with heart failure due to left ventricular dysfunction, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, or valsartan/sacubitril along with beta blockers are recommended.

ACE inhibitor

ACE inhibitorsangiotensin converting enzyme inhibitorangiotensin-converting enzyme inhibitor
They selectively block the activation of AT 1 receptors, preventing the binding of angiotensin II compared to ACE inhibitors.
In 2012, there was a meta-analysis published in the BMJ that described the protective role of ACE inhibitors in reducing the risk of pneumonia when compared to ARBs.

Fimasartan

Other ARBs include candesartan (Atacand), telmisartan (Micardis), and Valsartan (Diovan), fimasartan (Kanarb). Losartan, irbesartan, olmesartan, candesartan, valsartan, fimasartan and azilsartan include the tetrazole group (a ring with four nitrogen and one carbon).
Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure.

Valsartan

Diovan
Other ARBs include candesartan (Atacand), telmisartan (Micardis), and Valsartan (Diovan), fimasartan (Kanarb). Losartan, irbesartan, olmesartan, candesartan, valsartan, fimasartan and azilsartan include the tetrazole group (a ring with four nitrogen and one carbon).
It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II.

Losartan

CozaarLosartan Potassium
In one study after 10 weeks of treatment with an ARB called losartan (Cozaar), 88% of hypertensive males with sexual dysfunction reported improvement in at least one area of sexuality, and overall sexual satisfaction improved from 7.3% to 58.5%. Losartan, irbesartan, olmesartan, candesartan, valsartan, fimasartan and azilsartan include the tetrazole group (a ring with four nitrogen and one carbon).
It is in the angiotensin receptor blocker family of medication.

Angiotensin II receptor type 1

AT 1 AT1 receptorAGTR1
They selectively block the activation of AT 1 receptors, preventing the binding of angiotensin II compared to ACE inhibitors.
Angiotensin II receptor antagonists are drugs indicated for hypertension, diabetic nephropathy and congestive heart failure.

Angiotensin

angiotensin IIangiotensin Iangiotensinogen
They selectively block the activation of AT 1 receptors, preventing the binding of angiotensin II compared to ACE inhibitors.
The action of AII itself is targeted by angiotensin II receptor antagonists, which directly block angiotensin II AT 1 receptors.

Telmisartan

Micardis
Other ARBs include candesartan (Atacand), telmisartan (Micardis), and Valsartan (Diovan), fimasartan (Kanarb). Nearly all ARBs contain biphenyltetrazole moiety except telmisartan and eprosartan.
It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II.

Hyperkalemia

high blood potassiumhyperkalaemiahigh blood potassium levels
Common adverse drug reactions (ADRs) include: dizziness, headache, and/or hyperkalemia.
Examples of medications that can cause hyperkalemia include ACE inhibitors, angiotensin receptor blockers, beta blockers, and calcineurin inhibitor immunosuppressants such as ciclosporin and tacrolimus.

Hypertension

high blood pressurehypertensivearterial hypertension
ARBs and the similar-attributed ACE inhibitors are both indicated as the first-line antihypertensives in patients developing hypertension along the left-sided heart failure. Their main uses are in the treatment of hypertension (high blood pressure), diabetic nephropathy (kidney damage due to diabetes) and congestive heart failure. ARB inhibitors, although have protective effects against developing kidney diseases for patients with diabetes and previously hypertension without administration of ARBs, may worsen kidney functions such as causing further reduction of glomerular filtration rate associated with rise of serum creatinine in patients suffering practically clinical or already clinically present proteinuria, renal artery stenosis, hypertensive nephrosclerosis, heart failure, polycystic kidney disease, chronic kidney disease, interstitial fibrosis, focal segmental glomerulosclerosis, or any conditions such as ARBs-treated but still clinically hypertension that lead to abnormal narrowing of blood vessels to the kidney that interrupts oxygen and nutrients supply to the organ.
First-line medications for hypertension include thiazide-diuretics, calcium channel blockers, angiotensin converting enzyme inhibitors (ACE inhibitors), and angiotensin receptor blockers (ARBs).

Renin–angiotensin system

renin–angiotensin–aldosterone systemrenin-angiotensin-aldosterone systemrenin angiotensin system
Angiotensin II receptor blockers (ARBs), also known as angiotensin II receptor antagonists, AT 1 receptor antagonists or sartans, are a group of pharmaceuticals that modulate the renin–angiotensin system.

Migraine

migrainesmigraine headachemigraine headaches
Candesartan is used experimentally in preventive treatment of migraine.
Angiotensin inhibition by either an angiotensin-converting enzyme inhibitor or angiotensin II receptor antagonist may reduce attacks.

Angioedema

angiooedemaangioneurotic edemahereditary angioedema
They do not inhibit the breakdown of bradykinin or other kinins, and are thus only rarely associated with the persistent dry cough and/or angioedema that limit ACE inhibitor therapy.
In people with ACE inhibitor angioedema, the drug needs to be discontinued and an alternative treatment needs to be found, such as an angiotensin II receptor blocker (ARB), which has a similar mechanism but does not affect bradykinin.

Indigestion

dyspepsiafunctional dyspepsiadyspeptic
Infrequent ADRs associated with therapy include: first dose orthostatic hypotension, rash, diarrhea, dyspepsia, abnormal liver function, muscle cramp, myalgia, back pain, insomnia, decreased hemoglobin levels, renal impairment, pharyngitis, and/or nasal congestion.
Many medications cause dyspepsia, including aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics (metronidazole, macrolides), diabetes drugs (metformin, Alpha-glucosidase inhibitor, amylin analogs, GLP-1 receptor antagonists), antihypertensive medications (angiotensin converting enzyme [ACE] inhibitors, Angiotensin II receptor antagonist), cholesterol-lowering agents (niacin, fibrates), neuropsychiatric medications (cholinesterase inhibitors [donepezil, rivastigmine]), SSRIs (fluoxetine, sertraline), serotonin-norepinephrine-reuptake inhibitors (venlafaxine, duloxetine), Parkinson drugs (Dopamine agonist, monoamine oxidase [MAO]-B inhibitors), corticosteroids, estrogens, digoxin, iron, and opioids.

Azilsartan

Azilsartan medoxomilazilsartan kamedoxomil
Losartan, irbesartan, olmesartan, candesartan, valsartan, fimasartan and azilsartan include the tetrazole group (a ring with four nitrogen and one carbon).
Azilsartan is an angiotensin II receptor antagonist used in the treatment of hypertension, developed by Takeda.

Chronic kidney disease

chronic renal failureend-stage renal diseasechronic kidney failure
ARB inhibitors, although have protective effects against developing kidney diseases for patients with diabetes and previously hypertension without administration of ARBs, may worsen kidney functions such as causing further reduction of glomerular filtration rate associated with rise of serum creatinine in patients suffering practically clinical or already clinically present proteinuria, renal artery stenosis, hypertensive nephrosclerosis, heart failure, polycystic kidney disease, chronic kidney disease, interstitial fibrosis, focal segmental glomerulosclerosis, or any conditions such as ARBs-treated but still clinically hypertension that lead to abnormal narrowing of blood vessels to the kidney that interrupts oxygen and nutrients supply to the organ.
Angiotensin converting enzyme inhibitors (ACEIs) or angiotensin II receptor antagonists (ARBs) are generally first-line agents for blood pressure control, as they slow progression of the kidney disease and the risk of heart disease.

Eprosartan

Teveten
Nearly all ARBs contain biphenyltetrazole moiety except telmisartan and eprosartan.
Eprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure.

Polycystic kidney disease

polycystic kidneypolycystic kidneysAutosomal dominant polycystic kidney disease
ARB inhibitors, although have protective effects against developing kidney diseases for patients with diabetes and previously hypertension without administration of ARBs, may worsen kidney functions such as causing further reduction of glomerular filtration rate associated with rise of serum creatinine in patients suffering practically clinical or already clinically present proteinuria, renal artery stenosis, hypertensive nephrosclerosis, heart failure, polycystic kidney disease, chronic kidney disease, interstitial fibrosis, focal segmental glomerulosclerosis, or any conditions such as ARBs-treated but still clinically hypertension that lead to abnormal narrowing of blood vessels to the kidney that interrupts oxygen and nutrients supply to the organ.
Hypertension is treated with angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs).

Olmesartan

olmesartan medoxomilBenicar
Losartan, irbesartan, olmesartan, candesartan, valsartan, fimasartan and azilsartan include the tetrazole group (a ring with four nitrogen and one carbon).
It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II.

Myocardial infarction

heart attackheart attacksacute myocardial infarction
The issue of whether angiotensin II receptor antagonists slightly increase the risk of myocardial infarction (MI or heart attack) is currently being investigated.
Those who cannot tolerate ACE inhibitors may be treated with an angiotensin II receptor antagonist.

Irbesartan

AvaproAvalide
Losartan, irbesartan, olmesartan, candesartan, valsartan, fimasartan and azilsartan include the tetrazole group (a ring with four nitrogen and one carbon).
It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II.

Diabetes

diabetes mellitusdiabeticdiabetics
Their main uses are in the treatment of hypertension (high blood pressure), diabetic nephropathy (kidney damage due to diabetes) and congestive heart failure. ARB inhibitors, although have protective effects against developing kidney diseases for patients with diabetes and previously hypertension without administration of ARBs, may worsen kidney functions such as causing further reduction of glomerular filtration rate associated with rise of serum creatinine in patients suffering practically clinical or already clinically present proteinuria, renal artery stenosis, hypertensive nephrosclerosis, heart failure, polycystic kidney disease, chronic kidney disease, interstitial fibrosis, focal segmental glomerulosclerosis, or any conditions such as ARBs-treated but still clinically hypertension that lead to abnormal narrowing of blood vessels to the kidney that interrupts oxygen and nutrients supply to the organ.
Among medications that lower blood pressure, angiotensin converting enzyme inhibitors (ACEIs) improve outcomes in those with diabetes while the similar medications angiotensin receptor blockers (ARBs) do not.