A report on Anterograde amnesia and Eszopiclone

Hippocampus (brain)

This has also been recorded in non-benzodiazepine sedatives or "z-drugs" which act on the same set of receptors; such as zolpidem (also known as Ambien), eszopiclone (also known as Lunesta), and zopiclone (also known by brand names Imovane and Zimovane).

- Anterograde amnesia

Long-term use of sedative-hypnotics for insomnia lacks an evidence base and has traditionally been discouraged for reasons that include concerns about such potential adverse drug effects as cognitive impairment (anterograde amnesia), daytime sedation, motor incoordination, and increased risk of motor vehicle accidents and falls.

- Eszopiclone
Hippocampus (brain)

3 related topics with Alpha

Overall
Chemical structure of the prototypical Z-drug zolpidem

Nonbenzodiazepine

2 links

Nonbenzodiazepines, sometimes referred to colloquially as Z-drugs (as many of them begin with the letter "z"), are a class of psychoactive drugs that are very benzodiazepine-like in nature.

Nonbenzodiazepines, sometimes referred to colloquially as Z-drugs (as many of them begin with the letter "z"), are a class of psychoactive drugs that are very benzodiazepine-like in nature.

Chemical structure of the prototypical Z-drug zolpidem
Core structures of selected nonbenzodiazepines (left three diagrams) and the structure of benzodiazepines (right) for comparison

Eszopiclone (Lunesta, Valnoc, etc.)

Long-term use of sedative-hypnotics for insomnia lacks an evidence base and is discouraged for reasons that include concerns about such potential adverse drug effects as cognitive impairment (anterograde amnesia), daytime sedation, motor incoordination, and increased risk of motor vehicle accidents and falls.

A 7.5 mg zopiclone tablet.

Zopiclone

1 links

Nonbenzodiazepine used to treat difficulty sleeping.

Nonbenzodiazepine used to treat difficulty sleeping.

A 7.5 mg zopiclone tablet.
Two major zopiclone metabolites.

Although withdrawal symptoms from therapeutic doses of zopiclone and its isomers (i.e., eszopiclone) do not typically present with convulsions and are therefore not considered life-threatening, patients may experience such significant agitation or anxiety that they seek emergency medical attention.

Long-term use of sedative-hypnotics for insomnia lacks an evidence base and is discouraged for reasons that include concerns about such potential adverse drug effects as cognitive impairment (anterograde amnesia), daytime sedation, motor incoordination, and increased risk of motor vehicle accidents and falls.

Structural formula of benzodiazepines.

Benzodiazepine

1 links

Fusion of a benzene ring and a diazepine ring.

Fusion of a benzene ring and a diazepine ring.

Structural formula of benzodiazepines.
Midazolam 1 & 5 mg/mL injections (Canada)
Temazepam (Normison) 10 mg tablets
Addiction experts in psychiatry, chemistry, pharmacology, forensic science, epidemiology, and the police and legal services engaged in delphic analysis regarding 20 popular recreational drugs. Benzodiazepines were ranked in this graph 7th in dependence, physical harm, and social harm.
Diazepam 2 mg and 5 mg diazepam tablets, which are commonly used in the treatment of benzodiazepine withdrawal.
Chlordiazepoxide 5 mg capsules, which are sometimes used as an alternative to diazepam for benzodiazepine withdrawal. Like diazepam it has a long elimination half-life and long-acting active metabolites.
Schematic diagram of the (α1)2(β2)2(γ2) GABAA receptor complex that depicts the five-protein subunits that form the receptor, the chloride (Cl−) ion channel pore at the center, the two GABA active binding sites at the α1 and β2 interfaces and the benzodiazepine (BZD) allosteric binding site at the α1 and γ2 interface.
Left: The 1,4-benzodiazepine ring system. Right: 5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one forms the skeleton of many of the most common benzodiazepine pharmaceuticals, such as diazepam (7-chloro-1-methyl substituted).
A pharmacophore model of the benzodiazepine binding site on the GABAA receptor. White sticks represent the carbon atoms of the benzodiazepine diazepam, while green represents carbon atoms of the nonbenzodiazepine CGS-9896. Red and blue sticks are oxygen and nitrogen atoms that are present in both structures. The red spheres labeled H1 and H2/A3 are, respectively, hydrogen bond donating and accepting sites in the receptor, while L1, L2, and L3 denote lipophilic binding sites.
The molecular structure of chlordiazepoxide, the first benzodiazepine. It was marketed by Hoffmann–La Roche from 1960 branded as Librium.
Xanax (alprazolam) 2 mg tri-score tablets

High doses of many shorter-acting benzodiazepines may also cause anterograde amnesia and dissociation.

For treatment of insomnia, benzodiazepines are now less popular than nonbenzodiazepines, which include zolpidem, zaleplon and eszopiclone.