A report on Long-term memory and Anterograde amnesia

Hippocampus (brain)

In neurology, anterograde amnesia is a loss of the ability to create new memories after the event that caused amnesia, leading to a partial or complete inability to recall the recent past, while long-term memories from before the event remain intact.

- Anterograde amnesia

His subsequent total anterograde amnesia and partial retrograde amnesia provided the first evidence for the localization of memory function, and further clarified the differences between declarative and procedural memory.

- Long-term memory
Hippocampus (brain)

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Overall
Humans have two hippocampi, one in each hemisphere of the brain. They are located in the medial temporal lobes of the cerebrum. In this lateral view of the human brain, the frontal lobe is at the left, the occipital lobe at the right, and the temporal and parietal lobes have largely been removed to reveal one of the hippocampi underneath.

Hippocampus

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Major component of the brain of humans and other vertebrates.

Major component of the brain of humans and other vertebrates.

Humans have two hippocampi, one in each hemisphere of the brain. They are located in the medial temporal lobes of the cerebrum. In this lateral view of the human brain, the frontal lobe is at the left, the occipital lobe at the right, and the temporal and parietal lobes have largely been removed to reveal one of the hippocampi underneath.
Image 1: The human hippocampus and fornix (left) compared with a seahorse (right)
Image 2: Cross-section of cerebral hemisphere showing structure and location of hippocampus
Image 3: Coronal section of the brain of a macaque monkey, showing hippocampus (circled)
Image 4: Basic circuit of the hippocampus, as drawn by Cajal DG: dentate gyrus. Sub: subiculum. EC: entorhinal cortex
Image 5: Hippocampal location and regions
Rats and cognitive maps
Image 6: Spatial firing patterns of 8 place cells recorded from the CA1 layer of a rat. The rat ran back and forth along an elevated track, stopping at each end to eat a small food reward. Dots indicate positions where action potentials were recorded, with color indicating which neuron emitted that action potential.
Image 7: Examples of rat hippocampal EEG and CA1 neural activity in the theta (awake/behaving) and LIA (slow-wave sleep) modes. Each plot shows 20 seconds of data, with a hippocampal EEG trace at the top, spike rasters from 40 simultaneously recorded CA1 pyramidal cells in the middle (each raster line represents a different cell), and a plot of running speed at the bottom. The top plot represents a time period during which the rat was actively searching for scattered food pellets. For the bottom plot the rat was asleep.
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Image 9: An EEG showing epilepsy right-hippocampal seizure onset
Image 10: An EEG showing epilepsy left-hippocampal seizure onset
Image 11: Drawing by Italian pathologist Camillo Golgi of a hippocampus stained using the silver nitrate method
thumb|Hippocampus highlighted in green on coronal T1 MRI images
thumb|Hippocampus highlighted in green on sagittal T1 MRI images
thumb|Hippocampus highlighted in green on transversal T1 MRI images

The hippocampus is part of the limbic system, and plays important roles in the consolidation of information from short-term memory to long-term memory, and in spatial memory that enables navigation.

People with extensive, bilateral hippocampal damage may experience anterograde amnesia: the inability to form and retain new memories.

Amnesie

Amnesia

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Deficit in memory caused by brain damage or disease, but it can also be caused temporarily by the use of various sedatives and hypnotic drugs.

Deficit in memory caused by brain damage or disease, but it can also be caused temporarily by the use of various sedatives and hypnotic drugs.

Amnesie

There are two main types of amnesia: retrograde amnesia and anterograde amnesia.

Anterograde amnesia is the inability to transfer new information from the short-term store into the long-term store.

Episodic memory

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Memory of everyday events that can be explicitly stated or conjured.

Memory of everyday events that can be explicitly stated or conjured.

Along with semantic memory, it comprises the category of explicit memory, one of the two major divisions of long-term memory (the other being implicit memory).

For example, anterograde amnesia, from damage of the medial temporal lobe, is an impairment of declarative memory that affects both episodic and semantic memory operations.

The line processes to make information memory

Memory consolidation

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Category of processes that stabilize a memory trace after its initial acquisition.

Category of processes that stabilize a memory trace after its initial acquisition.

The line processes to make information memory
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Systematic studies of anterograde amnesia started to emerge in the 1960s and 1970s.

Long-term memory, when discussed in the context of synaptic consolidation, is conventionally said to be memory that lasts for at least 24 hours.

Hippocampus as seen in red

Explicit memory

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Hippocampus as seen in red
Amygdala as seen in red
The Morris water maze

Explicit memory (or declarative memory) is one of the two main types of long-term human memory, the other of which is implicit memory.

Guy Pearce plays an ex-insurance investigator suffering from severe anterograde amnesia caused by a head injury.

Lobes of the human brain (temporal lobe is shown in green)

Temporal lobe

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One of the four major lobes of the cerebral cortex in the brain of mammals.

One of the four major lobes of the cerebral cortex in the brain of mammals.

Lobes of the human brain (temporal lobe is shown in green)
Animation showing the position of the human left temporal lobe

The temporal lobe communicates with the hippocampus and plays a key role in the formation of explicit long-term memory modulated by the amygdala.

The medial temporal lobes include the hippocampi, which are essential for memory storage, therefore damage to this area can result in impairment in new memory formation leading to permanent or temporary anterograde amnesia.

Retrograde amnesia

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Loss of memory-access to events that occurred or information that was learned in the past.

Loss of memory-access to events that occurred or information that was learned in the past.

Anterograde amnesia is a similar condition that deals with the inability to form new memories following the onset of an injury or disease.

The hippocampus deals largely with memory consolidation, where information from the working memory and short-term memory is encoded into long-term storage for future retrieval. Amnesic patients with damage to the hippocampus are able to demonstrate some degree of unimpaired semantic memory, despite a loss of episodic memory, due to spared parahippocampal cortex. In other words, retrograde amnesics "know" about information or skill, but cannot "remember" how they do.

Short-term memory

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Capacity for holding a small amount of information in an active, readily available state for a short interval.

Capacity for holding a small amount of information in an active, readily available state for a short interval.

In contrast, long-term memory holds information indefinitely.

One form of evidence cited in favor of the existence of a short-term store comes from anterograde amnesia, the inability to learn new facts and episodes.