A report on Anterograde amnesia and Temazepam

Prepn: S. C. Bell, (1965 to Am. Home. Prod.). See also: E. Reeder et al., and (1967, 1968, both to Hoffmann-La Roche).

This disorder is usually acquired in one of four ways: One cause is benzodiazepine drugs such as midazolam, flunitrazepam, lorazepam, temazepam, nitrazepam, triazolam, clonazepam, alprazolam, diazepam, and nimetazepam; all of these are known to have powerful amnesic effects.

- Anterograde amnesia

Anterograde amnesia may also develop, as may respiratory depression in higher doses.

- Temazepam

3 related topics with Alpha

Benzodiazepine

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Fusion of a benzene ring and a diazepine ring.

Midazolam 1 & 5 mg/mL injections (Canada)

Addiction experts in psychiatry, chemistry, pharmacology, forensic science, epidemiology, and the police and legal services engaged in delphic analysis regarding 20 popular recreational drugs. Benzodiazepines were ranked in this graph 7th in dependence, physical harm, and social harm.

Diazepam 2 mg and 5 mg diazepam tablets, which are commonly used in the treatment of benzodiazepine withdrawal.

Chlordiazepoxide 5 mg capsules, which are sometimes used as an alternative to diazepam for benzodiazepine withdrawal. Like diazepam it has a long elimination half-life and long-acting active metabolites.

Schematic diagram of the (α1)2(β2)2(γ2) GABAA receptor complex that depicts the five-protein subunits that form the receptor, the chloride (Cl−) ion channel pore at the center, the two GABA active binding sites at the α1 and β2 interfaces and the benzodiazepine (BZD) allosteric binding site at the α1 and γ2 interface.

Left: The 1,4-benzodiazepine ring system. Right: 5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one forms the skeleton of many of the most common benzodiazepine pharmaceuticals, such as diazepam (7-chloro-1-methyl substituted).

A pharmacophore model of the benzodiazepine binding site on the GABAA receptor. White sticks represent the carbon atoms of the benzodiazepine diazepam, while green represents carbon atoms of the nonbenzodiazepine CGS-9896. Red and blue sticks are oxygen and nitrogen atoms that are present in both structures. The red spheres labeled H1 and H2/A3 are, respectively, hydrogen bond donating and accepting sites in the receptor, while L1, L2, and L3 denote lipophilic binding sites.

The molecular structure of chlordiazepoxide, the first benzodiazepine. It was marketed by Hoffmann–La Roche from 1960 branded as Librium.

Xanax (alprazolam) 2 mg tri-score tablets

High doses of many shorter-acting benzodiazepines may also cause anterograde amnesia and dissociation.

If used in pregnancy, those benzodiazepines with a better and longer safety record, such as diazepam or chlordiazepoxide, are recommended over potentially more harmful benzodiazepines, such as temazepam or triazolam.

Alprazolam

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Fast-acting tranquilizer of medium duration in the triazolobenzodiazepine class, which are benzodiazepines (BZDs) fused with a triazole ring.

Alprazolam pills in boxes, as sold in France. Both Xanax (original Pfizer alprazolam product) and various generic forms of alprazolam are depicted here.

Binding at the α1β3γ2 GABAA receptor. Alprazolam with red space-filling carbon atoms. γ2 receptor subunit in mint green. The α1' subunit is hidden.

Alprazolam is metabolized into 4-hydroxyalprazolam (top) and α-hydroxyalprazolam (bottom).

Anterograde amnesia and concentration problems

The benzodiazepines diazepam and oxazepam have been found to produce fewer withdrawal reactions than alprazolam, temazepam, or lorazepam.

Chemical structure of the prototypical Z-drug zolpidem

Nonbenzodiazepine

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Nonbenzodiazepines, sometimes referred to colloquially as Z-drugs (as many of them begin with the letter "z"), are a class of psychoactive drugs that are very benzodiazepine-like in nature.

Core structures of selected nonbenzodiazepines (left three diagrams) and the structure of benzodiazepines (right) for comparison

While this effect is rare (and has also been reported to occur with some of the older sedative drugs such as temazepam and secobarbital), it can be potentially hazardous, and so further development of this class of drugs has continued in an effort to find new compounds with further improved profiles.

Long-term use of sedative-hypnotics for insomnia lacks an evidence base and is discouraged for reasons that include concerns about such potential adverse drug effects as cognitive impairment (anterograde amnesia), daytime sedation, motor incoordination, and increased risk of motor vehicle accidents and falls.