Germinal epithelium of the testicle.
1: basal lamina
2: spermatogonia
3: spermatocyte 1st order
4: spermatocyte 2nd order
5: spermatid
6: mature spermatid
7: Sertoli cell
8: tight junction (blood testis barrier)
AMH bound to its type II receptor, AMHR2 (PDB: 7L0J)
section of a tubule of the testis of a rat. X 250.

AMH is activated by SOX9 in the Sertoli cells of the male fetus.

- Anti-Müllerian hormone

anti-Müllerian hormone (AMH) — secreted during the early stages of fetal life.

- Sertoli cell
Germinal epithelium of the testicle.
1: basal lamina
2: spermatogonia
3: spermatocyte 1st order
4: spermatocyte 2nd order
5: spermatid
6: mature spermatid
7: Sertoli cell
8: tight junction (blood testis barrier)

2 related topics

Alpha

A representation of the 3D structure of the protein myoglobin showing turquoise α-helices. This protein was the first to have its structure solved by X-ray crystallography. Toward the right-center among the coils, a prosthetic group called a heme group (shown in gray) with a bound oxygen molecule (red).

SOX9

Protein that in humans is encoded by the SOX9 gene.

Protein that in humans is encoded by the SOX9 gene.

A representation of the 3D structure of the protein myoglobin showing turquoise α-helices. This protein was the first to have its structure solved by X-ray crystallography. Toward the right-center among the coils, a prosthetic group called a heme group (shown in gray) with a bound oxygen molecule (red).

It is expressed by proliferating but not hypertrophic chondrocytes that is essential for differentiation of precursor cells into chondrocytes and, with steroidogenic factor 1, regulates transcription of the anti-Müllerian hormone (AMH) gene.

SOX-9 also plays a pivotal role in male sexual development; by working with Sf1, SOX-9 can produce AMH in Sertoli cells to inhibit the creation of a female reproductive system.

The Activin dimer, from 2ARV.pdb

Activin and inhibin

Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects.

Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects.

The Activin dimer, from 2ARV.pdb
Schematic diagram of the 1D structures of inhibin and activin. The black line between the monomers represents a disulfide bond.

Activin, inhibin and a number of other structurally related proteins such as anti-Müllerian hormone, bone morphogenetic protein, and growth differentiation factor belong to the TGF-β protein superfamily.

It is secreted from the Sertoli cells, located in the seminiferous tubules inside the testes.