Antithyroid agent

antithyroidantithyroid drugsact against thyroid hormonesAnti Thyroid drugsanti-thyroid agentsanti-thyroid drugsanti-thyroid medicationantithyroid agentsantithyroid drugantithyroid medication
An antithyroid agent is a hormone antagonist acting upon thyroid hormones.wikipedia
36 Related Articles

Propylthiouracil

6-''n''-propyl-2-thiouracil6-''n''-propylthiouracil6-n-propylthiouracil
The main antithyroid drugs are carbimazole (in the UK), methimazole (in the US), and propylthiouracil/PTU. Others include granulocytopenia (dose dependent, which improves on cessation of the drug) and aplastic anemia, and—for propylthiouracil—severe, fulminant liver failure.
Propylthiouracil is in the antithyroid family of medications.

Graves' disease

Graves diseaseGrave's diseaseGraves’ disease
In Graves' disease, treatment with antithyroid medications must be given for six months to two years, in order to be effective.
Medications such as beta blockers may control some of the symptoms, and antithyroid medications such as methimazole may temporarily help people while other treatments are having effect.

Potassium perchlorate

KClO 4 perchloratePerchloracap
A less common antithyroid agent is potassium perchlorate.
Potassium perchlorate can be used as an antithyroid agent used to treat hyperthyroidism, usually in combination with one other medication.

Hormone antagonist

hormone antagonistsHormone receptor antagonists
An antithyroid agent is a hormone antagonist acting upon thyroid hormones.

Thyroid hormones

thyroid hormonethyroxineT4
An antithyroid agent is a hormone antagonist acting upon thyroid hormones.

Carbimazole

The main antithyroid drugs are carbimazole (in the UK), methimazole (in the US), and propylthiouracil/PTU.

Thiamazole

methimazoleTapazole
The main antithyroid drugs are carbimazole (in the UK), methimazole (in the US), and propylthiouracil/PTU.

Randomized controlled trial

randomized controlled trialsrandomized clinical trialrandomized control trial
A randomized control trial testing single dose treatment for Graves' found methimazole achieved euthyroid state more effectively after 12 weeks than did propylthyouracil (77.1% on methimazole 15 mg vs 19.4% in the propylthiouracil 150 mg groups).

Thyrotropin receptor

TSH receptorTSHRthyroid stimulating hormone receptor
These two markers are an elevated level of thyroid stimulating hormone receptor antibodies (TSHR-Ab) and smoking.

Antibody

antibodiesimmunoglobulinimmunoglobulins
These two markers are an elevated level of thyroid stimulating hormone receptor antibodies (TSHR-Ab) and smoking.

Sensitivity and specificity

sensitivityspecificitysensitive
A positive TSHR-Ab at the end of antithyroid drug treatment increases the risk of recurrence to 90% (sensitivity 39%, specificity 98%), a negative TSHR-Ab at the end of antithyroid drug treatment is associated with a 78% chance of remaining in remission.

Agranulocytosis

Acquired agranulocytosisdecrease in blood cellsgranulopenia
The most dangerous side-effect is agranulocytosis (1/250, more in PTU); this is an idiosyncratic reaction which generally resolves on cessation of drug.

Neutropenia

neutropenicneutropaeniaChronic neutropenia
Others include granulocytopenia (dose dependent, which improves on cessation of the drug) and aplastic anemia, and—for propylthiouracil—severe, fulminant liver failure.

Aplastic anemia

aplastic anaemiaaplasticacquired aplastic anemia
Others include granulocytopenia (dose dependent, which improves on cessation of the drug) and aplastic anemia, and—for propylthiouracil—severe, fulminant liver failure.

Peripheral neuropathy

neuropathyneuropathiesneuropathic
The most common side effects are rash and peripheral neuritis.

Placenta

placental barrierchorioallantoic placentaafterbirth
These drugs also cross the placenta and are secreted in breast milk.

Breast milk

human milkhuman breast milkbreastmilk
These drugs also cross the placenta and are secreted in breast milk.

Thyroglobulin

TGAnti-thyroglobulin antibodiesProloid
Some scientists believe that anti-thyroids inhibit iodination of tyrosyl residues in thyroglobulin.

Tyrosine

Tyrtyrosine metabolismL-tyrosine
It is thought that they inhibit the thyroperoxidase catalyzed oxidation reactions by acting as substrates for the postulated peroxidase-iodine complex, thus competitively inhibiting the interaction with the amino acid tyrosine.

ATC code H03

H03B code of antithyroid preparations
* H03B code of antithyroid preparations

Hyperthyroidism

thyrotoxicosishyperthyroidoveractive thyroid
Medications such as beta blockers may control the symptoms, and anti-thyroid medications such as methimazole may temporarily help people while other treatments are having effect.

Dibromotyrosine

Dibromotyrosine is an antithyroid preparation and a derivative of the natural amino acid tyrosine.