Structures of the brainstem, the origin of the arousal system, viewed along the sagittal plane
Coronal section of the pons, at its upper part. (Formatio reticularis labeled at left.)
Rhomboid fossa. (Locus coeruleus not labeled, but is very near [just lateral to] the colliculus facialis, which is labeled at center left.)
A cross section of the lower part of the pons showing the pontine reticular formation labeled as #9
Locus coeruleus and its influence pathways
Ascending reticular activating system. Reticular formation labeled near center.
Spinal cord tracts - reticulospinal tract labeled in red, near-center at left in figure

It involves activation of the ascending reticular activating system (ARAS) in the brain, which mediates wakefulness, the autonomic nervous system, and the endocrine system, leading to increased heart rate and blood pressure and a condition of sensory alertness, desire, mobility, and readiness to respond.

- Arousal

It is a part of the reticular activating system.

- Locus coeruleus

Neurons of the reticular formation, particularly those of the ascending reticular activating system, play a crucial role in maintaining behavioral arousal and consciousness.

- Reticular formation

The noradrenergic system is a bundle of axons that originate in the locus coeruleus and ascends up into the neocortex, limbic system, and basal forebrain.

- Arousal

The norepinephrine from the LC has an excitatory effect on most of the brain, mediating arousal and priming the brain's neurons to be activated by stimuli.

- Locus coeruleus

The adrenergic component of the reticular activating system is closely associated with the noradrenergic neurons of the locus coeruleus.

- Reticular formation
Structures of the brainstem, the origin of the arousal system, viewed along the sagittal plane

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