A report on Artemisinin and Artemether
It is in the artemisinin class of medication.
- ArtemetherWhere artesunate is not available, the WHO recommends intramuscular injection of the less potent artemisinin derivative artemether.
- Artemisinin4 related topics with Alpha
Artesunate
2 linksMedication used to treat malaria.
Medication used to treat malaria.
It is in the artemisinin class of medication.
Artesunate's efficacy is comparable to that of artemether, another artemisinin derivative, in treating adults for severe malaria caused by Plasmodium falciparum, though artesunate clears more parasites initially.
Antimalarial medication
2 linksAntimalarial medications or simply antimalarials are a type of antiparasitic chemical agent, often naturally derived, that can be used to treat or to prevent malaria, in the latter case, most often aiming at two susceptible target groups, young children and pregnant women.
Antimalarial medications or simply antimalarials are a type of antiparasitic chemical agent, often naturally derived, that can be used to treat or to prevent malaria, in the latter case, most often aiming at two susceptible target groups, young children and pregnant women.
Incidence and distribution of the disease ("malaria burden") is expected to remain high, globally, for many years to come; moreover, known antimalarial drugs have repeatedly been observed to elicit resistance in the malaria parasite—including for combination therapies featuring artemisinin, a drug of last resort, where resistance has now been observed in Southeast Asia.
Artemether is a methyl ether derivative of dihydroartemesinin. It is similar to artemesinin in mode of action but demonstrates a reduced ability as a hypnozoiticidal compound, instead acting more significantly to decrease gametocyte carriage. Similar restrictions are in place, as with artemesinin, to prevent the development of resistance, therefore it is only used in combination therapy for severe acute cases of drug-resistant P. falciparum. It should be administered in a 7-day course with 4 mg/kg given per day for three days, followed by 1.6 mg/kg for three days. Side effects of the drug are few but include potential neurotoxicity developing if high doses are given.
Artemisia annua
2 linksCommon type of wormwood native to temperate Asia, but naturalized in many countries including scattered parts of North America.
Common type of wormwood native to temperate Asia, but naturalized in many countries including scattered parts of North America.
An extract of A. annua, called artemisinin (or artesunate), is a medication used to treat malaria.
An improved extract was obtained by using a low-temperature, ether-based extraction method, further showing the artemisinin derivative, artemether, to be an effective antimalarial drug.
Artemether/lumefantrine
0 linksArtemether/lumefantrine, sold under the trade name Coartem among others, is a combination of the two medications artemether and lumefantrine.
In 2001, the first fixed dose artemisinin-based combination therapy to meet the World Health Organization's (WHO) pre-qualification criteria for efficacy, safety and quality was created.