Atorvastatin

LipitorAtorvastatin Calciummodern drugssotis (schottische)
Atorvastatin, sold under the trade name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipid levels.wikipedia
227 Related Articles

Statin

statinsHMG-CoA reductase inhibitorHMG-CoA reductase inhibitors
Atorvastatin, sold under the trade name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipid levels.
There are various forms of statins, some of which include atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin.

HMG-CoA reductase

HMG CoA reductasebeta-hydroxy beta-methylglutaryl-CoA reductaseHMGCoA reductase
Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in the liver that plays a role in producing cholesterol.
These drugs include rosuvastatin (CRESTOR), lovastatin (Mevacor), atorvastatin (Lipitor), pravastatin (Pravachol), fluvastatin (Lescol), pitavastatin (Livalo), and simvastatin (Zocor).

Erythromycin

erythromycin estolateerythromycin ethylsuccinateA/T/S
This is less likely to happen with other CYP3A4 inhibitors such as diltiazem, erythromycin, fluconazole, ketoconazole, clarithromycin, cyclosporine, protease inhibitors, or verapamil, and only rarely with other CYP3A4 inhibitors, such as amiodarone and aprepitant.
If other CYP3A substrates — drugs that are broken down by CYP3A — such as simvastatin (Zocor), lovastatin (Mevacor), or atorvastatin (Lipitor)—are taken concomitantly with erythromycin, levels of the substrates increase, often causing adverse effects.

CYP3A4

cytochrome P450 3A43A4cytochrome P450-3A4
Co-administration of atorvastatin with one of CYP3A4 inhibitors such as itraconazole, telithromycin, and voriconazole, may increase serum concentrations of atorvastatin, which may lead to adverse reactions.

Combined hyperlipidemia

Familial combined hyperlipidemiaCombined hyperlipidemia, familialhyperlipidemia, familial combined
Statin drugs, especially the synthetic statins (atorvastatin and rosuvastatin), can decrease LDL levels by increasing hepatic reuptake of LDL due to increased LDL-receptor expression.

Aldol reaction

aldolaldol additionaldol reactions
An early enantioselective route to atorvastatin made use of an ester chiral auxiliary to set the stereochemistry of the first of the two alcohol functional groups via a diastereoselective aldol reaction.
and the synthesis of the heart disease drug Lipitor (atorvastatin, calcium salt).

Pfizer

Pfizer Inc.Pfizer, Inc.Pfizer Inc
Atorvastatin calcium tablets are marketed by Pfizer under the trade name Lipitor for oral administration.
Its products include the blockbuster drug Lipitor (atorvastatin), used to lower LDL blood cholesterol; Lyrica (pregabalin) for neuropathic pain and fibromyalgia; Diflucan (fluconazole), an oral antifungal medication; Zithromax (azithromycin), an antibiotic; Viagra (sildenafil) for erectile dysfunction; and Celebrex (also Celebra, celecoxib), an anti-inflammatory drug.

Rifampicin

rifampinRifadinRimactane
Only rarely, though, barbiturates, carbamazepine, efavirenz, nevirapine, oxcarbazepine, rifampin, and rifamycin, which are also CYP3A4 inducers, can decrease the plasma concentrations of atorvastatin.
Other interactions include decreased levels and less effectiveness of antiretroviral agents, everolimus, atorvastatin, rosiglitazone, pioglitazone, celecoxib, clarithromycin, caspofungin, voriconazole, and lorazepam.

Lovastatin

mevinolinMevacorAltocor
Warner-Lambert management was concerned that atorvastatin was a me-too version of rival Merck & Co.'s orphan drug lovastatin (brand name Mevacor).
As with atorvastatin, simvastatin, and other statin drugs metabolized via CYP3A4, drinking grapefruit juice during lovastatin therapy may increase the risk of side effects.

Ranbaxy Laboratories

RanbaxyRanbaxy PharmaceuticalsRanbaxy Laboratories Limited
Initially, generic atorvastatin was manufactured only by Watson Pharmaceuticals and India's Ranbaxy Laboratories.
In December 2005, Ranbaxy's share price was hit by a patent ruling disallowing production of its own version of Pfizer's cholesterol-cutting drug Lipitor, which has annual sales of more than $10 billion.

Chiral auxiliary

chiral auxiliariesauxiliary
An early enantioselective route to atorvastatin made use of an ester chiral auxiliary to set the stereochemistry of the first of the two alcohol functional groups via a diastereoselective aldol reaction.
The calcium salt of atorvastatin is marketed under the trade name Lipitor for the lowering of blood cholesterol.

Cardiovascular disease

heart diseasecardiac diseasecardiovascular
Atorvastatin, sold under the trade name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipid levels.

Dyslipidemia

dyslipidaemiaabnormal lipid levelsabnormal blood lipid levels
Atorvastatin, sold under the trade name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipid levels.

Rhabdomyolysis

muscle breakdownrapid muscle breakdownbreakdown of skeletal muscle
Serious side effects may include rhabdomyolysis, liver problems, and diabetes. Interactions with clofibrate, fenofibrate, gemfibrozil, which are fibrates used in accessory therapy in many forms of hypercholesterolemia, usually in combination with statins, increase the risk of myopathy and rhabdomyolysis.

Diabetes

diabetes mellitusdiabeticdiabetics
Serious side effects may include rhabdomyolysis, liver problems, and diabetes.

Pregnancy

pregnantfirst trimesterpregnant women
Use during pregnancy may harm the baby.

Enzyme

enzymologyenzymesenzymatic
Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in the liver that plays a role in producing cholesterol.

Cholesterol

total cholesteroldietary cholesterolserum cholesterol
Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in the liver that plays a role in producing cholesterol.

Generic drug

generic medicationgenericgeneric drugs
It is available as a generic medication.

National Health Service

NHSNational Health Service (NHS)National Health Services
In the United Kingdom, it costs the NHS about £0.70 per month as of 2018.

Hypercholesterolemia

high cholesterolhigh blood cholesterolhypercholesterolaemia
Interactions with clofibrate, fenofibrate, gemfibrozil, which are fibrates used in accessory therapy in many forms of hypercholesterolemia, usually in combination with statins, increase the risk of myopathy and rhabdomyolysis.

Familial hypercholesterolemia

familial hypercholesterolaemiahypercholesterolemia, familialhereditary high cholesterol

Hyperlipidemia

hyperlipoproteinemiahyperlipidaemiaPrimary hyperlipoproteinemia

Low-density lipoprotein

LDLLDL cholesterollow density lipoprotein
Antacids can rarely decrease the plasma concentrations of statin medications, but do not affect the LDL-C-lowering efficacy.