Endoscopic image of an esophageal adenocarcinoma
Endoscopic image of Barrett's esophagus, which is the area of dark reddish-brown mucosa at the base of the
                   esophagus. (Biopsies showed intestinal metaplasia.)
The digestive tract, with the esophagus marked in red
Esophageal cancer (lower part) as a result of Barrettʼs esophagus
Histopathology of Barrett's esophagus, showing intestinalized epithelium with goblet cells, as opposed to normal stratified squamous epithelium of the esophagus, and pseudostratified columnar epithelium of the fundus of the stomach. The submucosa displays an infiltrate including lymphocytes and plasma cells, constituting an underlying chronic inflammation. The area between the stratified and the intestinalized epithelium displays reactive changes, but there is no secondary dysplasia in this case. H&E stain.
The esophagus is constricted in three places.
Esophageal cancer as shown by a filling defect during an upper GI series
In incomplete Barrett's esophagus, there are both foveolar cells and goblet cells, the latter (indicated by arrows) usually having a slightly bluish color compared to the apical cytoplasm of foveolar cells on H&E stain. An occasional but specific sign of goblet cells is crescent shaped nuclei (seen in middle one).
A mass seen during an endoscopy and an ultrasound of the mass conducted during the endoscopy session.
Esophageal stent for esophageal cancer
Micrograph showing Barrett's esophagus - columnar epithelia with goblet cells - on the left side of image; and normal stratified squamous epithelium on the right side of image Alcian blue stain
Esophageal stent for esophageal cancer
High-magnification micrograph of Barrett's esophagus showing the characteristic goblet cells, Alcian blue stain
Before and after a total esophagectomy
Endoscopic view of Barrett's esophagus showing location of biopsies for screening using the Seattle protocol
Typical scar lines after the two main methods of surgery
Barrettʼs cancer adenocarcinoma (poor; signet-ringcell)
Death from esophageal cancer per million persons in 2012
Endoscopic image of Barrett esophagus – a frequent precursor of esophageal adenocarcinoma
Endoscopy and radial endoscopic ultrasound images of a submucosal tumor in the central portion of the esophagus
Contrast CT scan showing an esophageal tumor (axial view)
Contrast CT scan showing an esophageal tumor (coronal view)
Esophageal cancer
Micrograph showing histopathological appearance of an esophageal adenocarcinoma (dark blue – upper-left of image) and normal squamous epithelium (upper-right of image) at H&E staining
T1, T2, and T3 stages of esophageal cancer
Stage T4 esophageal cancer
Esophageal cancer with spread to lymph nodes
Internal radiotherapy for esophageal cancer
Self-expandable metallic stents are sometimes used for palliative care

Esophageal cancer is cancer arising from the esophagus—the food pipe that runs between the throat and the stomach.

- Esophageal cancer

Barrett's esophagus is a condition in which there is an abnormal (metaplastic) change in the mucosal cells lining the lower portion of the esophagus, from stratified squamous epithelium to simple columnar epithelium with interspersed goblet cells that are normally present only in the small intestine and large intestine.

- Barrett's esophagus

This change is considered to be a premalignant condition because it is associated with a high incidence of further transition to esophageal adenocarcinoma, an often-deadly cancer.

- Barrett's esophagus

Adenocarcinoma arises from glandular cells present in the lower third of the esophagus, often where they have already transformed to intestinal cell type (a condition known as Barrett's esophagus).

- Esophageal cancer

The esophagus may be affected by gastric reflux, cancer, prominent dilated blood vessels called varices that can bleed heavily, tears, constrictions, and disorders of motility.

- Esophagus

Normally, the cardia of the stomach is immediately distal to the z-line and the z-line coincides with the upper limit of the gastric folds of the cardia; however, when the anatomy of the mucosa is distorted in Barrett's esophagus the true gastro-eshophageal junction can be identified by the upper limit of the gastric folds rather than the mucosal transition.

- Esophagus
Endoscopic image of an esophageal adenocarcinoma

2 related topics with Alpha


X-ray showing radiocontrast from the stomach (white material below diaphragm) entering the esophagus (three vertical collections of white material in the mid-line of the chest) due to severe reflux

Gastroesophageal reflux disease

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X-ray showing radiocontrast from the stomach (white material below diaphragm) entering the esophagus (three vertical collections of white material in the mid-line of the chest) due to severe reflux
Frontal view of severe tooth erosion in GERD.
Severe tooth erosion in GERD.
A comparison of a healthy condition to GERD
Endoscopic image of peptic stricture, or narrowing of the esophagus near the junction with the stomach: This is a complication of chronic gastroesophageal reflux disease and can be a cause of dysphagia or difficulty swallowing.

Gastroesophageal reflux disease (GERD) or gastro-oesophageal reflux disease (GORD) is a chronic condition in which stomach contents and acid rise up into the esophagus, resulting in symptoms and/or complications.

Complications include esophagitis, esophageal stricture, and Barrett's esophagus.

Esophageal adenocarcinoma – a form of cancer


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Burning sensation in the central chest or upper central abdomen.

Burning sensation in the central chest or upper central abdomen.

Heartburn is usually due to regurgitation of gastric acid (gastric reflux) into the esophagus.

Esophageal cancers

Endoscopy looking for erosive changes of the esophagus consistent with prolonged acid exposure (e.g. - Barrett's esophagus)