A report on TamoxifenBreast cancer and HER2/neu

Nolvadex (tamoxifen) 20 mg tablets.
An illustration of breast cancer
Her2 and Her3 distribution on a breast cell, (3D Dual Colour Super Resolution Microscopy SPDMphymod / LIMON, marked with Alexa 488 and 568)
Crystallographic structure of afimoxifene (carbon = white, oxygen = red, nitrogen = blue) complexed with ligand binding domain of estrogen receptor alpha (ERα) (cyan ribbon).
Breast cancer showing an inverted nipple, lump, and skin dimpling
Her 2 staining on patient breast cancer tissue identified as stage 3
Early signs of possible breast cancer
The staining is seen as a cell membrane with continuous brown color.
Tumor in the breast visualized by Breast-Computertomography (Breast-CT)
All types of alcoholic beverages, including beer, wine, or liquor, cause breast cancer.
Ducts and lobules, the main locations of breast cancers
Overview of signal transduction pathways involved in programmed cell death. Mutations leading to loss of this ability can lead to cancer formation.
Histopathologic types of breast cancer, with relative incidences and prognoses
A mobile breast cancer screening unit in New Zealand
Chest after right breast mastectomy
Internal radiotherapy for breast cancer
Breasts after double mastectomy followed by nipple-sparing reconstruction with implants
An extreme example of an advanced recurrent breast cancer with an ulcerating axillary mass
Breast cancer surgery in 18th century
Radical mastectomy, Halsted's surgical papers
The pink ribbon is a symbol to show support for breast cancer awareness.
MRI showing breast cancer
Excised human breast tissue, showing an irregular, dense, white stellate area of cancer 2cm in diameter, within yellow fatty tissue
High-grade invasive ductal carcinoma, with minimal tubule formation, marked pleomorphism, and prominent mitoses, 40x field
Micrograph showing a lymph node invaded by ductal breast carcinoma, with an extension of the tumor beyond the lymph node
Neuropilin-2 expression in normal breast and breast carcinoma tissue
F-18 FDG PET/CT: A breast cancer metastasis to the right scapula
Needle breast biopsy
Elastography shows stiff cancer tissue on ultrasound imaging.
Ultrasound image shows irregularly shaped mass of breast cancer.
Infiltrating (invasive) breast carcinoma
Mammograms showing a normal breast (left) and a breast with cancer (right)
Stage T1 breast cancer
Stage T2 breast cancer
Stage T3 breast cancer
Metastatic or stage 4 breast cancer
Stage 1A breast cancer
Stage 1B breast cancer
Stage 2A breast cancer
Stage 2A breast cancer
Stage 2B breast cancer
Stage 2B breast cancer
Stage 2B breast cancer
Stage 3A breast cancer
Stage 3A breast cancer
Stage 3A breast cancer
Stage 3B breast cancer
Stage 3B breast cancer
Stage 4 breast cancer

Tamoxifen, sold under the brand name Nolvadex among others, is a selective estrogen receptor modulator used to prevent breast cancer in women and treat breast cancer in women and men.

- Tamoxifen

Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer.

- HER2/neu

The medications tamoxifen or raloxifene may be used in an effort to prevent breast cancer in those who are at high risk of developing it.

- Breast cancer

Normally, estradiol and tamoxifen acting through the estrogen receptor down-regulate the expression of HER2.

- HER2/neu

Tamoxifen needs to block growth factor proteins such as ErbB2/HER2 because high levels of ErbB2 have been shown to occur in tamoxifen resistant cancers.

- Tamoxifen

New or potentially new markers for breast cancer include BRCA1 and BRCA2 to identify people at high risk of developing breast cancer, HER-2, and SCD1, for predicting response to therapeutic regimens, and urokinase plasminogen activator, PA1-1 and SCD1 for assessing prognosis.

- Breast cancer
Nolvadex (tamoxifen) 20 mg tablets.

1 related topic with Alpha

Overall

The location and development of endometrial cancer.

Endometrial cancer

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Cancer that arises from the endometrium .

Cancer that arises from the endometrium .

The location and development of endometrial cancer.
The location and development of endometrial cancer.
The autosomal dominant inheritance pattern seen in Lynch syndrome
Immunohistochemistry of endometrial endometrioid carcinoma with wild-type pattern of p53 expression, with variable proportion of tumor cell nuclei staining with variable intensity.
Vaginal ultrasonography with an endometrial fluid accumulation (darker area) in a postmenopausal uterus, a finding that is highly suspicious for endometrial cancer
Polypoidal endometrial carcinoma
Relative incidences of endometrial carcinomas by histopathology.
Endometrioid endometrial adenocarcinoma—very high magnification—H&E stain
A keyhole hysterectomy, one possible surgery to treat endometrial cancer
alt=A diagram of stage IA and IB endometrial cancer|Stage IA and IB endometrial cancer
alt=A diagram of stage II endometrial cancer|Stage II endometrial cancer
alt=A diagram of stage III endometrial cancer|Stage III endometrial cancer
alt=A diagram of stage IV endometrial cancer|Stage IV endometrial cancer

Risk factors for endometrial cancer include obesity, insulin resistance and diabetes mellitus, breast cancer, use of tamoxifen, never having had a child, late menopause, high levels of estrogen, and increasing age.

The Her2/neu oncogene, which indicates a poor prognosis, is expressed in 20% of endometrioid and serous carcinomas.