CCL20

chemokine ligand 20MIP-3 alpha
Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family.wikipedia
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Chemokine

chemokinesCC chemokineCC chemokines
Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family.

CC chemokine receptors

CCR1CCR7CCR3
CCL20 elicits its effects on its target cells by binding and activating the chemokine receptor CCR6.
CCR6, a receptor for CCL20, is expressed on unactivated memory T-cells and some dendritic cells.

Cytokine

cytokineschemical signalscytokine-
Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family.

Chemotaxis

chemotacticchemoattractantchemotactic factor
It is strongly chemotactic for lymphocytes and weakly attracts neutrophils.

Lymphocyte

lymphocyteslymphocyticlymphoid cells
It is strongly chemotactic for lymphocytes and weakly attracts neutrophils. CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues. CCL20 is expressed in several tissues with highest expression observed in peripheral blood lymphocytes, lymph nodes, liver, appendix, and fetal lung and lower levels in thymus, testis, prostate and gut.

Neutrophil

neutrophilsneutrophil granulocyteneutrophilic
It is strongly chemotactic for lymphocytes and weakly attracts neutrophils.

Mucous membrane

mucosamucous membranesmucosal
CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues.

Lymphatic system

lymphoidlymphoid tissuelymphatic
CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues.

Dendritic cell

dendritic cellsmyeloid dendritic cellsdendritic
CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues.

Epithelium

epithelialepithelial cellsepithelial cell
CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues.

Chemokine receptor

chemokine receptorsreceptors for chemokinesCCR1
CCL20 elicits its effects on its target cells by binding and activating the chemokine receptor CCR6.

Gene

genesnumber of genesgene sequence
Gene expression of CCL20 can be induced by microbial factors such as lipopolysaccharide (LPS), and inflammatory cytokines such as tumor necrosis factor and interferon-γ, and down-regulated by IL-10.

Microorganism

microorganismsmicrobemicrobes
Gene expression of CCL20 can be induced by microbial factors such as lipopolysaccharide (LPS), and inflammatory cytokines such as tumor necrosis factor and interferon-γ, and down-regulated by IL-10.

Lipopolysaccharide

endotoxinLPSlipopolysaccharides
Gene expression of CCL20 can be induced by microbial factors such as lipopolysaccharide (LPS), and inflammatory cytokines such as tumor necrosis factor and interferon-γ, and down-regulated by IL-10.

Tumor necrosis factor superfamily

TNFtumor necrosis factortumour necrosis factor
Gene expression of CCL20 can be induced by microbial factors such as lipopolysaccharide (LPS), and inflammatory cytokines such as tumor necrosis factor and interferon-γ, and down-regulated by IL-10.

Interferon

interferonsIFNIFN-γ
Gene expression of CCL20 can be induced by microbial factors such as lipopolysaccharide (LPS), and inflammatory cytokines such as tumor necrosis factor and interferon-γ, and down-regulated by IL-10.

Interleukin 10

IL-10interleukin-10IL10
Gene expression of CCL20 can be induced by microbial factors such as lipopolysaccharide (LPS), and inflammatory cytokines such as tumor necrosis factor and interferon-γ, and down-regulated by IL-10.

Lymph node

lymph glandslymph nodesfollicles
CCL20 is expressed in several tissues with highest expression observed in peripheral blood lymphocytes, lymph nodes, liver, appendix, and fetal lung and lower levels in thymus, testis, prostate and gut.

Liver

hepaticliver protein synthesislivers
CCL20 is expressed in several tissues with highest expression observed in peripheral blood lymphocytes, lymph nodes, liver, appendix, and fetal lung and lower levels in thymus, testis, prostate and gut.

Appendix (anatomy)

appendixvermiform appendixvermiform
CCL20 is expressed in several tissues with highest expression observed in peripheral blood lymphocytes, lymph nodes, liver, appendix, and fetal lung and lower levels in thymus, testis, prostate and gut.

Fetus

fetalfoetusfetuses
CCL20 is expressed in several tissues with highest expression observed in peripheral blood lymphocytes, lymph nodes, liver, appendix, and fetal lung and lower levels in thymus, testis, prostate and gut.

Lung

lungspulmonaryright lung
CCL20 is expressed in several tissues with highest expression observed in peripheral blood lymphocytes, lymph nodes, liver, appendix, and fetal lung and lower levels in thymus, testis, prostate and gut.

NF-κB

NF-kBNF-kappaBNFκB
CCL20 expression was observed to be dependent on IL-6 amplifier activation, which is dependent on NF-κB and STAT3 activation.

STAT3

signal transducer and activator of transcription 3signal-transducer and activator of transcription 3STAT
CCL20 expression was observed to be dependent on IL-6 amplifier activation, which is dependent on NF-κB and STAT3 activation.