CD80

B7-1B7.1antigens, cd80B7-H1CD8
Cluster of differentiation 80 (also CD80 and B7-1) is a B7, type I membrane protein that is in the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding.wikipedia
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CTLA-4

CTLA4CD152cytotoxic T-lymphocyte antigen 4
CD80 can be found on the surface of various immune cells including dendritic cells, B cells, monocytes and antigen-presenting cells (APCs) and is the receptor for the proteins CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation) found on the surface of T-cells. In addition to interactions with CD28 and CTLA-4, CD80 is also thought to interact with a separate ligand on Natural Killer cells, triggering the Natural Killer cell-mediated cell death of the CD80 carrier.
It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.

CD28

antigens, cd28coreceptor CD28
CD80 can be found on the surface of various immune cells including dendritic cells, B cells, monocytes and antigen-presenting cells (APCs) and is the receptor for the proteins CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation) found on the surface of T-cells. When the major histocompatibility complex class II (MHC class II)- peptide complex on a dendritic cell interacts with the receptor on a T helper cell, CD80 is up-regulated, licensing the dendritic cell and allowing for interaction between the dendritic cell and CD 8 + T-cells via CD28. This activation occurs through stimulatory interaction with CD28, which can enhance cytokine production, and cell proliferation, and prevent apoptosis. CD80 interaction with CD28 also further stimulates dendritic cells, again enhancing cytokine production, specifically IL-6, a proinflammatory molecule. Neutrophils can also activate macrophages with CD80 viaCD28. In addition to interactions with CD28 and CTLA-4, CD80 is also thought to interact with a separate ligand on Natural Killer cells, triggering the Natural Killer cell-mediated cell death of the CD80 carrier.
CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins.

Immunoglobulin superfamily

Immunoglobulin (Ig) superfamilyimmunoglobulinIg
Cluster of differentiation 80 (also CD80 and B7-1) is a B7, type I membrane protein that is in the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding.

CD86

B7-2B7.2antigens, cd86
It is closely related to CD86, another B7 protein (B7-2), and often works in tandem, binding to the same receptors to prime T cells.
CD86 works in tandem with CD80 to prime T cells.

T helper cell

Th1Th2T helper cells
When the major histocompatibility complex class II (MHC class II)- peptide complex on a dendritic cell interacts with the receptor on a T helper cell, CD80 is up-regulated, licensing the dendritic cell and allowing for interaction between the dendritic cell and CD 8 + T-cells via CD28.
The second signal involves an interaction between CD28 on the CD4 + T cell and the proteins CD80 (B7.1) or CD86 (B7.2) on the professional APCs.

Dendritic cell

dendritic cellsmyeloid dendritic cellsdendritic
CD80 can be found on the surface of various immune cells including dendritic cells, B cells, monocytes and antigen-presenting cells (APCs) and is the receptor for the proteins CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation) found on the surface of T-cells. When the major histocompatibility complex class II (MHC class II)- peptide complex on a dendritic cell interacts with the receptor on a T helper cell, CD80 is up-regulated, licensing the dendritic cell and allowing for interaction between the dendritic cell and CD 8 + T-cells via CD28. CD80 is an especially important component in dendritic cell licensing and cytotoxic T-cell activation. This interaction results in an important costimulatory signal in the immunological synapse between antigen-presenting cells, B-cells, dendritic cells and T-cells that result in T and B-cell activation, proliferation and differentiation. Dendritic cells have been found to be suppressed by a CTLA-4-CD80 interaction and this interaction also promotes the suppressive effects of regulatory T cells, which can prevent an immune response to self-antigen. CD80 interaction with CD28 also further stimulates dendritic cells, again enhancing cytokine production, specifically IL-6, a proinflammatory molecule.
Simultaneously, they upregulate cell-surface receptors that act as co-receptors in T-cell activation such as CD80 (B7.1), CD86 (B7.2), and CD40 greatly enhancing their ability to activate T-cells.

Cytotoxic T cell

cytotoxic T cellsCD8+cytotoxic T lymphocytes
CD80 is an especially important component in dendritic cell licensing and cytotoxic T-cell activation.

Immunological synapse

immune synapsec-SMACimmunosynapse
This interaction results in an important costimulatory signal in the immunological synapse between antigen-presenting cells, B-cells, dendritic cells and T-cells that result in T and B-cell activation, proliferation and differentiation.
Also important are LFA-1, ICAM-1, CD28, and CD80/CD86.

Immune tolerance

immunological tolerancetoleranceself-antigen
Dendritic cells have been found to be suppressed by a CTLA-4-CD80 interaction and this interaction also promotes the suppressive effects of regulatory T cells, which can prevent an immune response to self-antigen.

T cell

T cellsT-cellT-cells
CD80 can be found on the surface of various immune cells including dendritic cells, B cells, monocytes and antigen-presenting cells (APCs) and is the receptor for the proteins CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation) found on the surface of T-cells. This interaction results in an important costimulatory signal in the immunological synapse between antigen-presenting cells, B-cells, dendritic cells and T-cells that result in T and B-cell activation, proliferation and differentiation.
The only co-stimulatory receptor expressed constitutively by naïve T cells is CD28, so co-stimulation for these cells comes from the CD80 and CD86 proteins, which together constitute the B7 protein, (B7.1 and B7.2, respectively) on the APC.

Monocyte

monocytesmonocyticmononuclear
CD80 can be found on the surface of various immune cells including dendritic cells, B cells, monocytes and antigen-presenting cells (APCs) and is the receptor for the proteins CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation) found on the surface of T-cells.

B cell

B cellsB-cellB lymphocytes
CD80 can be found on the surface of various immune cells including dendritic cells, B cells, monocytes and antigen-presenting cells (APCs) and is the receptor for the proteins CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation) found on the surface of T-cells. This interaction results in an important costimulatory signal in the immunological synapse between antigen-presenting cells, B-cells, dendritic cells and T-cells that result in T and B-cell activation, proliferation and differentiation.

MHC class II

MHC IIclass IIHLA class II
When the major histocompatibility complex class II (MHC class II)- peptide complex on a dendritic cell interacts with the receptor on a T helper cell, CD80 is up-regulated, licensing the dendritic cell and allowing for interaction between the dendritic cell and CD 8 + T-cells via CD28.

Cytokine

cytokineschemical signalscytokine-
This activation occurs through stimulatory interaction with CD28, which can enhance cytokine production, and cell proliferation, and prevent apoptosis. CD80 interaction with CD28 also further stimulates dendritic cells, again enhancing cytokine production, specifically IL-6, a proinflammatory molecule.

Apoptosis

apoptoticprogrammed cell deathcell death
This activation occurs through stimulatory interaction with CD28, which can enhance cytokine production, and cell proliferation, and prevent apoptosis.

Interleukin 6

IL-6interleukin-6IL6
CD80 interaction with CD28 also further stimulates dendritic cells, again enhancing cytokine production, specifically IL-6, a proinflammatory molecule.

Neutrophil

neutrophilsneutrophil granulocyteneutrophilic
Neutrophils can also activate macrophages with CD80 viaCD28.

Macrophage

macrophagesM2 macrophagesTissue macrophages
Neutrophils can also activate macrophages with CD80 viaCD28.

Regulatory T cell

regulatory T cellsTregTregs
Dendritic cells have been found to be suppressed by a CTLA-4-CD80 interaction and this interaction also promotes the suppressive effects of regulatory T cells, which can prevent an immune response to self-antigen.

Natural killer cell

NK cellsnatural killer cellsNK cell
In addition to interactions with CD28 and CTLA-4, CD80 is also thought to interact with a separate ligand on Natural Killer cells, triggering the Natural Killer cell-mediated cell death of the CD80 carrier.

Antigen-presenting cell

antigen-presenting cellsantigen presenting cellantigen presenting cells
CD80 can be found on the surface of various immune cells including dendritic cells, B cells, monocytes and antigen-presenting cells (APCs) and is the receptor for the proteins CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation) found on the surface of T-cells. This interaction results in an important costimulatory signal in the immunological synapse between antigen-presenting cells, B-cells, dendritic cells and T-cells that result in T and B-cell activation, proliferation and differentiation.

Autoimmune disease

autoimmune diseasesautoimmune disorderautoimmune
The up-regulation of CD80 has been linked to various autoimmune diseases, including

Multiple sclerosis

MSmultiple sclerosis (MS)disseminated sclerosis
multiple sclerosis, systemic lupus erythematosus and sepsis (which may partly be due to over-active T-cells), and CD80 has also been shown to help spread of HIV infection in the body.

Systemic lupus erythematosus

lupusSLEsystemic lupus erythematosus (SLE)
multiple sclerosis, systemic lupus erythematosus and sepsis (which may partly be due to over-active T-cells), and CD80 has also been shown to help spread of HIV infection in the body.

Sepsis

septicaemiablood poisoningseptic
multiple sclerosis, systemic lupus erythematosus and sepsis (which may partly be due to over-active T-cells), and CD80 has also been shown to help spread of HIV infection in the body.