A report on CYP2R1

Conversion of cholecalciferol to calcidiol as catalyzed by CYP2R1.

Cytochrome P450 2R1, an enzyme which is the principal vitamin D 25-hydroxylase.

- CYP2R1
Conversion of cholecalciferol to calcidiol as catalyzed by CYP2R1.

5 related topics with Alpha

Overall

Cholecalciferol

4 links

Type of vitamin D that is made by the skin when exposed to sunlight; it is found in some foods and can be taken as a dietary supplement.

Type of vitamin D that is made by the skin when exposed to sunlight; it is found in some foods and can be taken as a dietary supplement.

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It is converted to its active form by two hydroxylations: the first in the liver, by CYP2R1 or CYP27A1, to form 25-hydroxycholecalciferol (calcifediol, 25-OH vitamin D3).

Cholecalciferol (D3)

Vitamin D

4 links

Group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and many other biological effects.

Group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and many other biological effects.

Cholecalciferol (D3)
Calcium regulation in the human body. The role of active vitamin D (1,25-dihydroxyvitamin D, calcitriol) is shown in orange.
Global vitamin D serum levels among adults (nmol/L).
The photochemistry of vitamin D biosynthesis in animal and fungi
Thermal isomerization of previtaminD3 to vitamin D3
In the epidermal strata of the skin, vitamin D production is greatest in the stratum basale (colored red in the illustration) and stratum spinosum (colored light brown).
Liver hydroxylation of cholecalciferol to calcifediol
Kidney hydroxylation of calcifediol to calcitriol

This reaction is catalyzed by the microsomal enzyme vitamin D 25-hydroxylase, the product of the CYP2R1 human gene, and expressed by hepatocytes.

Calcifediol

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Calcifediol, also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D3 (abbreviated 25(OH)D3), is a form of vitamin D produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme vitamin D 25-hydroxylase.

Ergocalciferol

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Type of vitamin D found in food and used as a dietary supplement.

Type of vitamin D found in food and used as a dietary supplement.

Vitamin D2 supplements

It requires two hydroxylations to become active: the first in the liver by CYP2R1 to form 25-hydroxyergocalciferol (ercalcidiol or 25-OH D2 ), and the second in the kidney by CYP27B1, to form the active 1,25-dihydroxyergocalciferol (ercalcitriol or 1,25-(OH)2D2), which activates the vitamin D receptor.

X-ray of a two-year-old with rickets, with a marked bowing of the femurs and decreased bone density

Rickets

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Condition that results in weak or soft bones in children, and is caused by either dietary deficiency or genetic causes.

Condition that results in weak or soft bones in children, and is caused by either dietary deficiency or genetic causes.

X-ray of a two-year-old with rickets, with a marked bowing of the femurs and decreased bone density
Widening of wrist
Wrist X-ray showing changes in rickets. Mainly cupping is seen here.
Chest X-ray showing changes consistent with rickets. These changes are usually referred to as "rosary beads" of rickets.
Cholecalciferol (D3)
Ergocalciferol (D2)
Skeleton of Infant with Rickets, 1881

VDDR1B: CYP2R1 deficiency