A report on CYP2R1
Cytochrome P450 2R1, an enzyme which is the principal vitamin D 25-hydroxylase.
- CYP2R15 related topics with Alpha
Cholecalciferol
4 linksType of vitamin D that is made by the skin when exposed to sunlight; it is found in some foods and can be taken as a dietary supplement.
Type of vitamin D that is made by the skin when exposed to sunlight; it is found in some foods and can be taken as a dietary supplement.
It is converted to its active form by two hydroxylations: the first in the liver, by CYP2R1 or CYP27A1, to form 25-hydroxycholecalciferol (calcifediol, 25-OH vitamin D3).
Vitamin D
4 linksGroup of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and many other biological effects.
Group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and many other biological effects.
This reaction is catalyzed by the microsomal enzyme vitamin D 25-hydroxylase, the product of the CYP2R1 human gene, and expressed by hepatocytes.
Calcifediol
2 linksCalcifediol, also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D3 (abbreviated 25(OH)D3), is a form of vitamin D produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme vitamin D 25-hydroxylase.
Ergocalciferol
2 linksType of vitamin D found in food and used as a dietary supplement.
Type of vitamin D found in food and used as a dietary supplement.
It requires two hydroxylations to become active: the first in the liver by CYP2R1 to form 25-hydroxyergocalciferol (ercalcidiol or 25-OH D2 ), and the second in the kidney by CYP27B1, to form the active 1,25-dihydroxyergocalciferol (ercalcitriol or 1,25-(OH)2D2), which activates the vitamin D receptor.
Rickets
2 linksCondition that results in weak or soft bones in children, and is caused by either dietary deficiency or genetic causes.
Condition that results in weak or soft bones in children, and is caused by either dietary deficiency or genetic causes.
VDDR1B: CYP2R1 deficiency