Caenorhabditis elegans

C. eleganswormsC.elegansnematode wormsC ElegansCaenorhabditis elegans (C. elegans)nematodesCaenorabditis elegansCaenorhabditis eleganceCaenorhabditis. elegans
Caenorhabditis elegans is a free-living, transparent nematode, about 1 mm in length, that lives in temperate soil environments.wikipedia
854 Related Articles

Rhabditidae

RhabditisRhabditidesrhabditids
In 1900, Maupas initially named it Rhabditides elegans, Osche placed it in the subgenus Caenorhabditis in 1952, and in 1955, Dougherty raised Caenorhabditis to the status of genus.
The Rhabditidae are a family of nematodes which includes the model organism Caenorhabditis elegans.

Sydney Brenner

BrennerBrenner, SydneyDr Sydney Brenner
In 1963, Sydney Brenner proposed research into ''C.
He established the roundworm Caenorhabditis elegans as a model organism for the investigation of developmental biology, and founded the Molecular Sciences Institute in Berkeley, California, United States.

Connectome

brain graphsConnectome Projectconnectomes
It was the first multicellular organism to have its whole genome sequenced, and as of 2019, is the only organism to have its connectome (neuronal "wiring diagram") completed.
Research has successfully constructed the full connectome of one animal: the roundworm Caenorhabditis elegans, beginning with the first electron micrographs published by White, Brenner et al., 1986.

Ellsworth Dougherty

DoughertyEllsworth C. Dougherty
In 1900, Maupas initially named it Rhabditides elegans, Osche placed it in the subgenus Caenorhabditis in 1952, and in 1955, Dougherty raised Caenorhabditis to the status of genus.
Ellsworth C. Dougherty (1921-1965) was a biologist who was first to study the nematode worm Caenorhabditis elegans in the laboratory, with Victor Nigon, in the 1940s.

Whole genome sequencing

genome sequencingfull genome sequencingsequenced
It was the first multicellular organism to have its whole genome sequenced, and as of 2019, is the only organism to have its connectome (neuronal "wiring diagram") completed.
The first multicellular eukaryote, and animal, to have its whole genome sequenced was the nematode worm: Caenorhabditis elegans in 1998.

Model organism

animal modelmouse modelanimal models
elegans'', which has since been extensively used as a model organism.
Inquiries about the DNA of organisms are classed as genetic models (with short generation times, such as the fruitfly and nematode worm), experimental models, and genomic parsimony models, investigating pivotal position in the evolutionary tree.

Émile Maupas

Maupas
In 1900, Maupas initially named it Rhabditides elegans, Osche placed it in the subgenus Caenorhabditis in 1952, and in 1955, Dougherty raised Caenorhabditis to the status of genus.
Maupas first described Caenorhabditis elegans in 1900 and isolated it from soil in Algeria.

X0 sex-determination system

XX/XOX0 systemX0
elegans'' is based on an X0 sex-determination system.
The model organism Caenorhabditis elegans—a nematode frequently used in biological research—is one such organism.

MicroRNA

miRNAmicroRNAsmiRNAs
Many heterochronic genes code for microRNAs, which repress the expression of heterochronic transcription factors and other heterochronic miRNAs.
These groups published back-to-back papers on the lin-4 gene, which was known to control the timing of C. elegans larval development by repressing the lin-14 gene.

Hermaphrodite

hermaphroditichermaphroditismhermaphrodites
Most of these nematodes are hermaphrodites and a few are males.

Notch signaling pathway

NotchNotch signalingNotch receptor
Through Notch signaling, the P2 cell differentially specifies the ABp and ABa cells, which further defines the dorsal-ventral axis.
Alleles of the two C. elegans Notch genes were identified based on developmental phenotypes: lin-12 and glp-1.

Caenorhabditis

Caenorhabditis elegansDrosophilae' species supergroupJaponica group
The different Caenorhabditis species occupy various nutrient- and bacteria-rich environments.
The genus Caenorhabditis contains the noted model organism Caenorhabditis elegans and several other species for which a genome sequence is either available or currently being determined.

Dauer larva

dauerdauer larvaedauer stage
elegans can enter an alternative third larval stage, L2d, called the dauer stage (Dauer'' is German for permanent).
Dauer (German "die Dauer", English "the enduring", "the duration" in the meaning of "a length of time", from A.G. Fuchs (1937) Neue parasitische und halbparasitische Nematoden bei Borkenkäfern und einige andere Nematoden, English New Parasitic and Half-parasitic Nematodes with Bark-Beetles and Some Other Nematodes) describes an alternative developmental stage of nematode worms, particularly rhabditids including Caenorhabditis elegans, whereby the larva goes into a type of stasis and can survive harsh conditions.

Asymmetric cell division

asymmetricasymmetricallyasymmetric divisions
As a result of the difference in PAR protein distribution, the first cell division is highly asymmetric.
The cell biology of these events has been most studied in three animal models: the mouse, the nematode Caenorhabditis elegans, and the fruitfly Drosophila melanogaster.

Günther Osche

Osche
In 1900, Maupas initially named it Rhabditides elegans, Osche placed it in the subgenus Caenorhabditis in 1952, and in 1955, Dougherty raised Caenorhabditis to the status of genus.
He is known to have raised the name Rhabditides elegans in the subgenus Caenorhabditis in 1952 in the history of the naming of the model worm Caenorhabditis elegans.

Wnt signaling pathway

WntWnt signalingWnt signalling pathway
Through Wnt signaling, the P2 cell instructs the EMS cell to divide along the anterior-posterior axis.
It operates in both vertebrates and invertebrates, including humans, frogs, zebrafish, C. elegans, Drosophila and others.

Spermatheca

spermathecaereceptaculum seminissperm receptacles
Hermaphrodites have two ovaries, oviducts, and spermatheca, and a single uterus.
The nematode Caenorhabditis elegans has two spermathecae, one at the end of each gonad.

Cryptococcus kuetzingii

C. elegans can also use different species of yeast, including Cryptococcus laurentii and Cryptococcus kuetzingii, as sole source of food.
It can be used as sole source of food for the rearing of Caenorhabditis elegans.

RNA interference

RNAiregulatory RNApost transcriptional gene silencing
RNA interference (RNAi) is a relatively straightforward method of disrupting the function of specific genes.
Andrew Fire and Craig C. Mello shared the 2006 Nobel Prize in Physiology or Medicine for their work on RNA interference in the nematode worm Caenorhabditis elegans, which they published in 1998.

Cleavage (embryo)

cleavagespiral cleavageholoblastic
The fertilized zygote undergoes rotational holoblastic cleavage.

Nematocida parisii

N. parisii
One such species, Nematocida parisii, replicates in the intestines of ''C.
It is found in wild isolates of Caenorhabditis elegans.

Cryptococcus laurentii

C. elegans can also use different species of yeast, including Cryptococcus laurentii and Cryptococcus kuetzingii, as sole source of food.
It can also be used as sole source of food for the rearing of Caenorhabditis elegans.

Pseudomonas aeruginosa

P. aeruginosaPseudomonasPseudomonas aeruginosa'' infection
elegans can be killed by a number of pathogenic bacteria, including human pathogens such as Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella enterica or Enterococcus faecalis''.
Pyocyanin is a virulence factor of the bacteria and has been known to cause death in C. elegans by oxidative stress.

WormBase

WormBase ParaSite
As for most model organisms, scientists that work in the field curate a dedicated online database and the WormBase is that for ''C.
WormBase is an online biological database about the biology and genome of the nematode model organism Caenorhabditis elegans and contains information about other related nematodes.

Desiccation

desiccateddesiccatedesiccating
Nematodes can survive desiccation, and in ''C.
For example, in one study the investigators found that Caenorhabditis elegans dauer is a true anhydrobiote that can withstand extreme desiccation and that the basis of this ability is founded in the metabolism of trehalose.