A report on Vitamin DErgocalciferol and Calcitriol

Cholecalciferol (D3)
Calcium regulation in the human body. The role of active vitamin D (1,25-dihydroxyvitamin D, calcitriol) is shown in orange.
Vitamin D2 supplements
Global vitamin D serum levels among adults (nmol/L).
Calcitriol synthesis
The photochemistry of vitamin D biosynthesis in animal and fungi
Thermal isomerization of previtaminD3 to vitamin D3
In the epidermal strata of the skin, vitamin D production is greatest in the stratum basale (colored red in the illustration) and stratum spinosum (colored light brown).
Liver hydroxylation of cholecalciferol to calcifediol
Kidney hydroxylation of calcifediol to calcitriol

Ergocalciferol, also known as vitamin D2 and nonspecifically calciferol, is a type of vitamin D found in food and used as a dietary supplement.

- Ergocalciferol

Calcitriol is the active form of vitamin D, normally made in the kidney.

- Calcitriol

In humans, the most important compounds in this group are vitamin D3 (cholecalciferol) and vitamin D2 (ergocalciferol).

- Vitamin D

Instead it can be considered a hormone, with activation of the vitamin D pro-hormone resulting in the active form, calcitriol, which then produces effects via a nuclear receptor in multiple locations.

- Vitamin D

Compared to other vitamin D compounds in clinical use (cholecalciferol, ergocalciferol), calcitriol has a higher risk of inducing hypercalcemia.

- Calcitriol

The binding affinity of ercalcitriol to the vitamin D receptor is similar to that of calcitriol.

- Ergocalciferol
Cholecalciferol (D3)

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Cholecalciferol, also known as vitamin D3 and colecalciferol, is a type of vitamin D that is made by the skin when exposed to sunlight; it is found in some foods and can be taken as a dietary supplement.

It is converted in the liver to calcifediol (25-hydroxyvitamin D) which is then converted in the kidney to calcitriol (1,25-dihydroxyvitamin D).

There are conflicting reports concerning the relative effectiveness of cholecalciferol (D3) versus ergocalciferol (D2), with some studies suggesting less efficacy of D2, and others showing no difference.