A report on Cannabis (drug) and Cannabinoid receptor type 1

Close-up of flowering cannabis plant
Cnr1 is widely expressed in all major regions of the postnatal day 14 mouse brain, but is conspicuously absent in much of the thalamus.
Main short-term physical effects of cannabis
A joint prior to rolling, with a paper handmade filter on the left
Addiction experts in psychiatry, chemistry, pharmacology, forensic science, epidemiology, and the police and legal services engaged in delphic analysis regarding 20 popular recreational drugs. Cannabis was ranked 11th in dependence, 17th in physical harm, and 10th in social harm.
Types of cannabis
A macro cannabis bud
Present-day map of the Jirzankal Cemetery, site of the earliest evidence of cannabis smoking
Cannabis sativa from Vienna Dioscurides, c. 512 CE
Anti-Cannabis propaganda from 1935
Cannabis indica fluid extract, American Druggists Syndicate (pre-1937)
Process of making bhang in a Sikh village in Punjab, India. On the Hindu and Sikh festival of colors called Holi, it is a customary addition to some intoxicating drinks.
countries that have legalized medical use of cannabis
Example of a container and the recreational cannabis purchase in Canada.
Woman selling cannabis and bhang in Guwahati, Assam, India
Dried flower buds (marijuana)
A gram of kief
Hashish
Hash oil
Infusion (dairy butter)

It is activated by: endocannabinoids, a group of retrograde neurotransmitters that include anandamide and 2-arachidonoylglycerol (2-AG); plant phytocannabinoids, such as the compound THC which is an active ingredient of the psychoactive drug cannabis; and, synthetic analogs of THC.

- Cannabinoid receptor type 1

Cannabis use is also associated with downregulation of CB1 receptors.

- Cannabis (drug)
Close-up of flowering cannabis plant

4 related topics with Alpha

Overall
The bracts surrounding a cluster of Cannabis sativa flowers are coated with cannabinoid-laden trichomes

Cannabinoid

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The bracts surrounding a cluster of Cannabis sativa flowers are coated with cannabinoid-laden trichomes
Cannabis indica plant
Anandamide, an endogenous ligand of CB1 and CB2

Cannabinoids are compounds found in the cannabis plant or synthetic compounds that can interact with the endocannabinoid system. The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (Delta-9-THC), the primary intoxicating compound in cannabis.

Two known cannabinoid receptors are termed CB1 and CB2, with mounting evidence of more.

Tetrahydrocannabinol

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Principal psychoactive constituent of cannabis and one of at least 113 total cannabinoids identified on the plant.

Principal psychoactive constituent of cannabis and one of at least 113 total cannabinoids identified on the plant.

Although the chemical formula for THC (C21H30O2) describes multiple isomers, the term THC usually refers to the Delta-9-THC isomer with chemical name (−)-trans-Δ9-tetrahydrocannabinol. Like most pharmacologically active secondary metabolites of plants, THC is a lipid found in cannabis, assumed to be involved in the plant's evolutionary adaptation, putatively against insect predation, ultraviolet light, and environmental stress.

The actions of Delta-9-THC result from its partial agonist activity at the cannabinoid receptor CB1 (Ki = 40.7 nM ), located mainly in the central nervous system, and the CB2 receptor (Ki = 36 nM ), mainly expressed in cells of the immune system.

NMR solution structure of a peptide mimetic of the fourth cytoplasmic loop of the CB1 cannabinoid receptor based on the coordinates.

Cannabinoid receptor

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Involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory.

Involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory.

NMR solution structure of a peptide mimetic of the fourth cytoplasmic loop of the CB1 cannabinoid receptor based on the coordinates.
CB1 and CB2 structures

There are currently two known subtypes of cannabinoid receptors, termed CB1 and CB2.

Cannabinoid receptors are activated by cannabinoids, generated naturally inside the body (endocannabinoids) or introduced into the body as cannabis or a related synthetic compound.

Bag and contents of a well-known early brand of synthetic cannabinoids named Spice that contains herbs covered with synthetic cannabinoids, now illegal throughout much of the world

Synthetic cannabinoids

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Synthetic cannabinoids are a class of designer drug molecules that bind to the same receptors to which cannabinoids (THC, CBD and many others) in cannabis plants attach.

Synthetic cannabinoids are a class of designer drug molecules that bind to the same receptors to which cannabinoids (THC, CBD and many others) in cannabis plants attach.

Bag and contents of a well-known early brand of synthetic cannabinoids named Spice that contains herbs covered with synthetic cannabinoids, now illegal throughout much of the world
Dried flower buds sold as cannabis on the street may be laced.
A store selling synthetic cannabinoids in Riga in 2012

A large and complex variety of synthetic cannabinoids are designed in an attempt to avoid legal restrictions on cannabis, making synthetic cannabinoids designer drugs.

They have been designed to be similar to THC, the natural cannabinoid with the strongest binding affinity to the CB1 receptor, which is linked to the psychoactive effects or "high" of marijuana.