This malignancy allows for invasion into the circulation, followed by invasion to a second site for tumorigenesis.- Metastasis
Cancers that are confined within the wall of the colon may be curable with surgery, while cancer that has spread widely is usually not curable, with management being directed towards improving quality of life and symptoms.- Colorectal cancer
Other mutations enable the tumor to grow new blood vessels to provide more nutrients, or to metastasize, spreading to other parts of the body.- Carcinogenesis
For example, colorectal cancer spreads primarily through the portal vein to the liver.- Metastasis
As summarized in the articles Carcinogenesis and Neoplasm, for sporadic cancers in general, a deficiency in DNA repair is occasionally due to a mutation in a DNA repair gene, but is much more frequently due to epigenetic alterations that reduce or silence expression of DNA repair genes.- Colorectal cancer
Adenopolyposis colon cancer is associated with thousands of polyps in colon while young, leading to colon cancer at a relatively early age.- Carcinogenesis
1 related topic with Alpha
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
Early detection through screening is useful for cervical and colorectal cancer.
Several studies have indicated that the enzyme sirtuin 6 is selectively inactivated during oncogenesis in a variety of tumor types by inducing glycolysis.