Chlordiazepoxide

LibriumLimbitrolA-PoxideChlordiazachelchlordiazepoxide dibudinateChlordiazepoxide hydrochlorideLibreleaseLibritabsLygenMenrium
Chlordiazepoxide, trade name Librium among others, is a sedative and hypnotic medication of the benzodiazepine class; it is used to treat anxiety, insomnia and withdrawal symptoms from alcohol and/or drug abuse.wikipedia
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Chlordiazepoxide/clidinium bromide

Librax
It can sometimes be prescribed to ease symptoms of irritable bowel syndrome combined with clidinium bromide as a fixed dose medication, Librax.
Chlordiazepoxide/clidinium bromide (marketed as Librax) is a drug consisting of chlordiazepoxide (marketed separately under the trade name Librium) and clidinium bromide and used to treat peptic ulcers, irritable bowel syndrome (IBS), and gastritis.

Alcohol withdrawal syndrome

alcohol withdrawalwithdrawalalcohol
It is also indicated as a treatment for the management of acute alcohol withdrawal syndrome.
The typical treatment of alcohol withdrawal is with benzodiazepines such as chlordiazepoxide or diazepam.

Anxiolytic

anxiolysisanti-anxietyanxiolytics
The drug has amnesic, anticonvulsant, anxiolytic, hypnotic, sedative and skeletal muscle relaxant properties.

Benzodiazepine

benzodiazepinesbenzodiazapinesbenzo
Chlordiazepoxide, trade name Librium among others, is a sedative and hypnotic medication of the benzodiazepine class; it is used to treat anxiety, insomnia and withdrawal symptoms from alcohol and/or drug abuse.
The first such drug, chlordiazepoxide (Librium), was discovered accidentally by Leo Sternbach in 1955, and made available in 1960 by Hoffmann–La Roche, which, since 1963, has also marketed the benzodiazepine diazepam (Valium).

Benzodiazepine withdrawal syndrome

benzodiazepine withdrawalwithdrawal syndromebenzodiazepine
Chlordiazepoxide can cause physical dependence and what is known as the benzodiazepine withdrawal syndrome.
Long half-life benzodiazepines like diazepam or chlordiazepoxide are preferred to minimize rebound effects and are available in low potency dose forms.

Phenobarbital

phenobarbitoneLuminalHaplos
Chlordiazepoxide is similar to phenobarbital in its anticonvulsant properties.
The benzodiazepines chlordiazepoxide (Librium) and oxazepam (Serax) have largely replaced phenobarbital for detoxification.

Benzodiazepine dependence

dependencean addiction to the sleeping drug BenzodiazepineBarbiturate type dependence
A physical dependence develops more quickly with higher potency benzodiazepines such as alprazolam (Xanax) than with lower potency benzodiazepines such as chlordiazepoxide (Librium).

Diazepam

ValiumDizacCANA
Following chlordiazepoxide, in 1963 diazepam hit the market under the brand name Valium - and was followed by many further benzodiazepine compounds over the subsequent years and decades.
Other classical benzodiazepines include chlordiazepoxide, clonazepam, lorazepam, oxazepam, nitrazepam, temazepam, flurazepam, bromazepam, and clorazepate.

Temazepam

RestoriloxydiazepamTemaz
Sleep-related problems were treated with nitrazepam (Mogadon), which was introduced in 1972, temazepam (Restoril), which was introduced in 1979, and flurazepam (Dalmane), which was introduced in 1975.
Gradual and careful reduction of the dosage, preferably with a long-acting benzodiazepine with long half-life active metabolites, such as chlordiazepoxide or diazepam, are recommended to prevent severe withdrawal syndromes from developing.

Convention on Psychotropic Substances

Schedule IVamphetamine-type stimulantsSchedule I
Internationally, chlordiazepoxide is a Schedule IV controlled drug under the Convention on Psychotropic Substances.

Sedative

sedativessedative-hypnoticsedated
The drug has amnesic, anticonvulsant, anxiolytic, hypnotic, sedative and skeletal muscle relaxant properties. Chlordiazepoxide, trade name Librium among others, is a sedative and hypnotic medication of the benzodiazepine class; it is used to treat anxiety, insomnia and withdrawal symptoms from alcohol and/or drug abuse.

Hypnotic

sleeping pillssleeping pillsoporific
The drug has amnesic, anticonvulsant, anxiolytic, hypnotic, sedative and skeletal muscle relaxant properties. Chlordiazepoxide, trade name Librium among others, is a sedative and hypnotic medication of the benzodiazepine class; it is used to treat anxiety, insomnia and withdrawal symptoms from alcohol and/or drug abuse.

Anxiety

anxiousnervousnessanxieties
Chlordiazepoxide, trade name Librium among others, is a sedative and hypnotic medication of the benzodiazepine class; it is used to treat anxiety, insomnia and withdrawal symptoms from alcohol and/or drug abuse.

Insomnia

trouble sleepingsleeplessnessdifficulty sleeping
Chlordiazepoxide, trade name Librium among others, is a sedative and hypnotic medication of the benzodiazepine class; it is used to treat anxiety, insomnia and withdrawal symptoms from alcohol and/or drug abuse.

Drug withdrawal

withdrawalwithdrawal symptomswithdrawal syndrome
Chlordiazepoxide, trade name Librium among others, is a sedative and hypnotic medication of the benzodiazepine class; it is used to treat anxiety, insomnia and withdrawal symptoms from alcohol and/or drug abuse.

Half-life

half-liveshalf lifehalf lives
Chlordiazepoxide has a medium to long half-life but its active metabolite has a very long half-life.

Amnesia

memory lossamnesiacamnesic
The drug has amnesic, anticonvulsant, anxiolytic, hypnotic, sedative and skeletal muscle relaxant properties.

Anticonvulsant

anticonvulsantsantiepilepticantiepileptic drugs
The drug has amnesic, anticonvulsant, anxiolytic, hypnotic, sedative and skeletal muscle relaxant properties. Chlordiazepoxide is similar to phenobarbital in its anticonvulsant properties.

Irritable bowel syndrome

IBSSplenic flexure syndromeSplenic-flexure syndrome
It can sometimes be prescribed to ease symptoms of irritable bowel syndrome combined with clidinium bromide as a fixed dose medication, Librax.

Biological half-life

elimination half-lifehalf-lifeterminal half-life
Chlordiazepoxide is generally considered an inappropriate benzodiazepine for the elderly due to its long elimination half-life and the risks of accumulation.

Comorbidity

comorbidcomorbiditiesco-morbid
Benzodiazepines require special precaution if used in the elderly, pregnancy, children, alcohol- or drug-dependent individuals and individuals with comorbid psychiatric disorders.

Mental disorder

mental illnessnervous breakdownmentally ill
Benzodiazepines require special precaution if used in the elderly, pregnancy, children, alcohol- or drug-dependent individuals and individuals with comorbid psychiatric disorders.

Hypoventilation

respiratory depressiondecreased effort to breathedecreased breathing