A report on Malaria, Quinine and Chloroquine

Malaria parasite connecting to a red blood cell
Main symptoms of malaria
Tonic water, in normal light and ultraviolet "black light". The quinine content of tonic water causes it to fluoresce under black light.
Medical quinolines
The life cycle of malaria parasites. Sporozoites are introduced by a mosquito bite. They migrate to the liver, where they multiply into thousands of merozoites. The merozoites infect red blood cells and replicate, infecting more and more red blood cells. Some parasites form gametocytes, which are taken up by a mosquito, continuing the life cycle.
Quinine biosynthesis
Hemozoin formation in P. falciparum: many antimalarials are strong inhibitors of hemozoin crystal growth.
Micrograph of a placenta from a stillbirth due to maternal malaria. H&E stain. Red blood cells are anuclear; blue/black staining in bright red structures (red blood cells) indicate foreign nuclei from the parasites.
19th-century illustration of Cinchona calisaya
Resochin tablet package
Electron micrograph of a Plasmodium falciparum-infected red blood cell (center), illustrating adhesion protein "knobs"
The blood film is the gold standard for malaria diagnosis.
Ring-forms and gametocytes of Plasmodium falciparum in human blood
An Anopheles stephensi mosquito shortly after obtaining blood from a human (the droplet of blood is expelled as a surplus). This mosquito is a vector of malaria, and mosquito control is an effective way of reducing its incidence.
Man spraying kerosene oil in standing water, Panama Canal Zone, 1912
Walls where indoor residual spraying of DDT has been applied. The mosquitoes remain on the wall until they fall down dead on the floor.
A mosquito net in use.
An advertisement for quinine as a malaria treatment from 1927.
Deaths due to malaria per million persons in 2012
Past and current malaria prevalence in 2009
Ancient malaria oocysts preserved in Dominican amber
British doctor Ronald Ross received the Nobel Prize for Physiology or Medicine in 1902 for his work on malaria.
Chinese medical researcher Tu Youyou received the Nobel Prize for Physiology or Medicine in 2015 for her work on the antimalarial drug artemisinin.
Artemisia annua, source of the antimalarial drug artemisinin
U.S. Marines with malaria in a field hospital on Guadalcanal, October 1942
Members of the Malaria Commission of the League of Nations collecting larvae on the Danube delta, 1929
1962 Pakistani postage stamp promoting malaria eradication program
Malaria clinic in Tanzania
Child with malaria in Ethiopia
World War II poster
Disability-adjusted life year for malaria per 100,000 inhabitants in 2004 no data <10 0–100 100–500 500–1000 1000–1500 1500–2000 2000–2500 2500–2750 2750–3000 3000–3250 3250–3500 ≥3500

Quinine is a medication used to treat malaria and babesiosis.

- Quinine

Chloroquine is a medication primarily used to prevent and treat malaria in areas where malaria remains sensitive to its effects.

- Chloroquine

This includes the treatment of malaria due to Plasmodium falciparum that is resistant to chloroquine when artesunate is not available.

- Quinine

Quinine, along with doxycycline, may be used if artemisinin is not available.

- Malaria

Resistance among the parasites has developed to several antimalarial medications; for example, chloroquine-resistant P. falciparum has spread to most malarial areas, and resistance to artemisinin has become a problem in some parts of Southeast Asia.

- Malaria

It and related quinines have been associated with cases of retinal toxicity, particularly when provided at higher doses for longer times.

- Chloroquine
Malaria parasite connecting to a red blood cell

1 related topic with Alpha

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Plasmodium falciparum

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Laveran's drawing of various stages of P. falciparum as seen on fresh blood (1880).
Blood smear from a P. falciparum culture (K1 strain - asexual forms) - several red blood cells have ring stages inside them. Close to the center is a schizont and on the left a trophozoite.
Ring forms in red blood cells (Giemsa stain)
Life cycle of Plasmodium

Plasmodium falciparum is a unicellular protozoan parasite of humans, and the deadliest species of Plasmodium that causes malaria in humans.

Gize (1816) studied the extraction of crystalline quinine from the cinchona bark and Pelletier and Caventou (1820) in France extracted pure quinine alkaloids, which they named quinine and cinchonine.

In the late 1930s, the Germans developed chloroquine, which went into use in the North African campaigns.