A report on Chloroquine and Plasmodium vivax
]]Chloroquine has been used in the treatment and prevention of malaria from Plasmodium vivax, ''[[Plasmodium ovale|P.
- ChloroquineChloroquine remains the treatment of choice for vivax malaria, except in Indonesia's Irian Jaya (Western New Guinea) region and the geographically contiguous Papua New Guinea, where chloroquine resistance is common (up to 20% resistance).
- Plasmodium vivax5 related topics with Alpha
Malaria
4 linksMosquito-borne infectious disease that affects humans and other animals.
Mosquito-borne infectious disease that affects humans and other animals.
Most deaths are caused by P. falciparum, whereas P. vivax, P. ovale, and P. malariae generally cause a milder form of malaria.
Resistance among the parasites has developed to several antimalarial medications; for example, chloroquine-resistant P. falciparum has spread to most malarial areas, and resistance to artemisinin has become a problem in some parts of Southeast Asia.
Antimalarial medication
4 linksAntimalarial medications or simply antimalarials are a type of antiparasitic chemical agent, often naturally derived, that can be used to treat or to prevent malaria, in the latter case, most often aiming at two susceptible target groups, young children and pregnant women.
Antimalarial medications or simply antimalarials are a type of antiparasitic chemical agent, often naturally derived, that can be used to treat or to prevent malaria, in the latter case, most often aiming at two susceptible target groups, young children and pregnant women.
As well, despite very positive outcomes from many modern treatments, serious side effects can impact some individuals taking standard doses (e.g., retinopathy with chloroquine, acute haemolytic anaemia with tafenoquine).
Quinine is an alkaloid that acts as a blood schizonticidal and weak gametocide against Plasmodium vivax and Plasmodium malariae.
Plasmodium falciparum
3 linksUnicellular protozoan parasite of humans, and the deadliest species of Plasmodium that causes malaria in humans.
Unicellular protozoan parasite of humans, and the deadliest species of Plasmodium that causes malaria in humans.
In 1900, the Italian zoologist Giovanni Battista Grassi categorized Plasmodium species based on the timing of fever in the patient; malignant tertian malaria was caused by Laverania malariae (now P. falciparum), benign tertian malaria by Haemamoeba vivax (now P. vivax), and quartan malaria by Haemamoeba malariae (now P. malariae).
In the late 1930s, the Germans developed chloroquine, which went into use in the North African campaigns.
Plasmodium
3 linksGenus of unicellular eukaryotes that are obligate parasites of vertebrates and insects.
Genus of unicellular eukaryotes that are obligate parasites of vertebrates and insects.
Over the course of the 20th century, many other species were discovered in various hosts and classified, including five species that regularly infect humans: P. vivax, P. falciparum, P. malariae, P. ovale, and P. knowlesi.
Resistance to quinine spurred the development of a broad array of antimalarial medications through the 20th century including chloroquine, proguanil, atovaquone, sulfadoxine/pyrimethamine, mefloquine, and artemisinin.
Mefloquine
2 linksMedication used to prevent or treat malaria.
Medication used to prevent or treat malaria.
Mefloquine is used as a treatment for chloroquine-sensitive or resistant Plasmodium falciparum malaria, and is deemed a reasonable alternative for uncomplicated chloroquine-resistant Plasmodium vivax malaria.