Cholecalciferol

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Type of vitamin D that is made by the skin when exposed to sunlight; it is found in some foods and can be taken as a dietary supplement.

- Cholecalciferol

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Cholecalciferol (D3)

Calcifediol

Cholecalciferol (D3)

Calcifediol, also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D3 (abbreviated 25(OH)D3), is a form of vitamin D produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme vitamin D 25-hydroxylase.

Cholecalciferol (D3)

Vitamin D

Group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and many other biological effects.

Group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and many other biological effects.

Cholecalciferol (D3)
Calcium regulation in the human body. The role of active vitamin D (1,25-dihydroxyvitamin D, calcitriol) is shown in orange.
Global vitamin D serum levels among adults (nmol/L).
The photochemistry of vitamin D biosynthesis in animal and fungi
Thermal isomerization of previtaminD3 to vitamin D3
In the epidermal strata of the skin, vitamin D production is greatest in the stratum basale (colored red in the illustration) and stratum spinosum (colored light brown).
Liver hydroxylation of cholecalciferol to calcifediol
Kidney hydroxylation of calcifediol to calcitriol

In humans, the most important compounds in this group are vitamin D3 (also known as cholecalciferol) and vitamin D2 (ergocalciferol).

Calcitriol

Active form of vitamin D, normally made in the kidney.

Active form of vitamin D, normally made in the kidney.

Calcitriol synthesis

Compared to other vitamin D compounds in clinical use (cholecalciferol, ergocalciferol), calcitriol has a higher risk of inducing hypercalcemia.

X-ray of a two-year-old with rickets, with a marked bowing of the femurs and decreased bone density

Rickets

Condition that results in weak or soft bones in children, and is caused by either dietary deficiency or genetic causes.

Condition that results in weak or soft bones in children, and is caused by either dietary deficiency or genetic causes.

X-ray of a two-year-old with rickets, with a marked bowing of the femurs and decreased bone density
Widening of wrist
Wrist X-ray showing changes in rickets. Mainly cupping is seen here.
Chest X-ray showing changes consistent with rickets. These changes are usually referred to as "rosary beads" of rickets.
Cholecalciferol (D3)
Ergocalciferol (D2)
Skeleton of Infant with Rickets, 1881

Vitamin D3 (cholecalciferol) is the preferred form since it is more readily absorbed than vitamin D2.

The normal process of Vitamin D absorption

Vitamin D deficiency

Defined as a vitamin D level that is below normal.

Defined as a vitamin D level that is below normal.

The normal process of Vitamin D absorption
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Normal bone vs. Osteoporosis
Child with rickets
Vitamin D2 supplements

Since vitamin D3 (cholecalciferol) and vitamin D2 (ergocalciferol) are fat-soluble, humans and other animals with a skeleton need to store some fat.

Typical rat poison bait station (Germany, 2010)

Rodenticide

Rodenticides are chemicals made and sold for the purpose of killing rodents.

Rodenticides are chemicals made and sold for the purpose of killing rodents.

Typical rat poison bait station (Germany, 2010)
Poison baits infused with peanuts to attract rodents.
Rat poison vendor's stall at a market in Linxia City, China
Civilian Public Service worker distributes poisoned bait for typhus control in Gulfport, Mississippi, ca. 1945.
Wildlife eating rodenticide from a bait station intended for rats

Cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2) are used as rodenticides.

Multivitamins contain multiple micro-nutrients, such as vitamins and dietary minerals.

Multivitamin

Preparation intended to serve as a dietary supplement with vitamins, dietary minerals, and other nutritional elements.

Preparation intended to serve as a dietary supplement with vitamins, dietary minerals, and other nutritional elements.

Multivitamins contain multiple micro-nutrients, such as vitamins and dietary minerals.
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Centrum multivitamins produced by Pfizer, which were used in Physicians' Health Study II

Many multivitamin formulas contain vitamin C, B1, B2, B3, B5, B6, B7, B9, B12, A, E, D2 (or D3), K, potassium, iodine, selenium, borate, zinc, calcium, magnesium, manganese, molybdenum, beta carotene, and/or iron.

Ergocalciferol

Type of vitamin D found in food and used as a dietary supplement.

Type of vitamin D found in food and used as a dietary supplement.

Vitamin D2 supplements

Ergocalciferol may be used as a vitamin D supplement, whereas cholecalciferol (vitamin D3) is produced naturally by the skin when exposed to ultraviolet light.

Calcium within the periodic table

Hypercalcaemia

High calcium level in the blood serum.

High calcium level in the blood serum.

Calcium within the periodic table
Micrograph of ovarian small cell carcinoma of the hypercalcemic type. H&E stain.
An Osborn wave, an abnormal EKG tracing that can be associated with hypercalcemia.
Trisetum flavescens (yellow oat grass)

Plants such as Cestrum diurnum, and Solanum malacoxylon contain ergocalciferol or cholecalciferol which cause the onset of hypercalcemia.

Wool fat tin (adeps lanae), at the Centre touristique de la Laine et de la Mode in Verviers, Belgium

Lanolin

Wax secreted by the sebaceous glands of wool-bearing animals.

Wax secreted by the sebaceous glands of wool-bearing animals.

Wool fat tin (adeps lanae), at the Centre touristique de la Laine et de la Mode in Verviers, Belgium
Lanolin ointment

7-Dehydrocholesterol from lanolin is used as a raw material for producing vitamin D3 by irradiation with ultraviolet light.