Choline kinase

Choline kinase (also known as CK,ChoK and choline phosphokinase) is an enzyme which catalyzes the first reaction in the choline pathway for phosphatidylcholine (PC) biosynthesis.wikipedia
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Choline

choline salicylateanticholinergicCholine bitartrate
This reaction involves the transfer of a phosphate group from adenosine triphosphate (ATP) to choline in order to form phosphocholine.
Choline can also be produced by the CDP-choline route, cytosolic choline kinases (CK) phosphorylate choline with ATP to phosphocholine (PChol).

Phosphocholine

O-phosphocholine
This reaction involves the transfer of a phosphate group from adenosine triphosphate (ATP) to choline in order to form phosphocholine. Thus, the two substrates of this enzyme are ATP and choline, whereas its two products are adenosine diphosphate (ADP) and O-phosphocholine.
Phosphocholine is made in a reaction, catalyzed by choline kinase, that converts ATP and choline into phosphocholine and ADP.

CHKB (gene)

CHKBCholine kinase beta
These isoforms are encoded by two separate genes, CHKA and CHKB and are only active in their homodimeric, heterodimeric and oligomeric forms.
The highly purified choline kinases from mammalian sources and their recombinant gene products have been shown to have ethanolamine kinase activity as well, indicating that both activities reside on the same protein.

Enzyme

enzymologyenzymesenzymatic
Choline kinase (also known as CK,ChoK and choline phosphokinase) is an enzyme which catalyzes the first reaction in the choline pathway for phosphatidylcholine (PC) biosynthesis.

Phosphatidylcholine

phosphatidylcholinesphosphatidyl cholinedioleoyl phosphatidylcholine
Choline kinase (also known as CK,ChoK and choline phosphokinase) is an enzyme which catalyzes the first reaction in the choline pathway for phosphatidylcholine (PC) biosynthesis.

Adenosine triphosphate

ATPadenosine triphosphate (ATP)adenosine 5'-triphosphate
This reaction involves the transfer of a phosphate group from adenosine triphosphate (ATP) to choline in order to form phosphocholine.

Substrate (chemistry)

substratessubstratesubstrate specificity
Thus, the two substrates of this enzyme are ATP and choline, whereas its two products are adenosine diphosphate (ADP) and O-phosphocholine.

Product (chemistry)

productsproductchemical products
Thus, the two substrates of this enzyme are ATP and choline, whereas its two products are adenosine diphosphate (ADP) and O-phosphocholine.

Adenosine diphosphate

ADPadenosine diphosphate (ADP)adenosine diphosphate sugars
Thus, the two substrates of this enzyme are ATP and choline, whereas its two products are adenosine diphosphate (ADP) and O-phosphocholine.

Cofactor (biochemistry)

cofactorcofactorscoenzyme
Choline kinase requires magnesium ions (+2) as a cofactor for this reaction.

Transferase

transferasesformyltransferasehydroxymethyltransferase
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor.

Phosphotransferase

phosphotransferase enzymesphosphotransferasesphosphotransfer
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor.

Electron acceptor

acceptorterminal electron acceptoracceptors
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor.

Ethanolamine kinase

A related enzyme, ethanolamine kinase, tends to co-purify with choline kinase leading to a suggestion that the two activities are mediated by two distinct active sites on a single protein.

Active site

catalytic domaincatalytic siteactive sites
A related enzyme, ethanolamine kinase, tends to co-purify with choline kinase leading to a suggestion that the two activities are mediated by two distinct active sites on a single protein.

List of enzymes

systematic nameclassifiedList of EC numbers
The systematic name of this enzyme class is ATP:choline phosphotransferase.

Code

encodingencodedencode
These isoforms are encoded by two separate genes, CHKA and CHKB and are only active in their homodimeric, heterodimeric and oligomeric forms.

Gene

genesnumber of genesgene sequence
These isoforms are encoded by two separate genes, CHKA and CHKB and are only active in their homodimeric, heterodimeric and oligomeric forms.

CHKA

These isoforms are encoded by two separate genes, CHKA and CHKB and are only active in their homodimeric, heterodimeric and oligomeric forms.

Biomolecular structure

structuresstructuretertiary structure
As of late 2007, six structures have been solved for this class of enzymes, with PDB accession codes,,,,, and.

Protein Data Bank

PDBProtein Data Bank (PDB)RCSB
As of late 2007, six structures have been solved for this class of enzymes, with PDB accession codes,,,,, and.

Caenorhabditis elegans

C. eleganswormsC.elegans
CKα-2 originating from C. elegans, is a dimeric enzyme with each monomer being composed of two domains.

Eukaryote

Eukaryotaeukaryoticeukaryotes
Its overall structure is similar to members of the eukaryotic protein kinase family.

Protein kinase

protein kinasestransmembranekinases
Its overall structure is similar to members of the eukaryotic protein kinase family.

Aminoglycoside

aminoglycosidesaminoglycoside antibioticaminoglycoside antibiotics
In this figure, there is a similarity between APH(3′)-IIIa, an aminoglycoside phosphotransferase and CK.