Cilostazol

Pletal
Cilostazol, sold under the brand name Pletal among others, is a medication used to help the symptoms of intermittent claudication in peripheral vascular disease.wikipedia
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Peripheral artery disease

peripheral vascular diseaseperipheral arterial diseasePeripheral artery occlusive disease
Cilostazol, sold under the brand name Pletal among others, is a medication used to help the symptoms of intermittent claudication in peripheral vascular disease.
Medications, including statins, ACE inhibitors, and cilostazol may also help.

PDE3 inhibitor

phosphodiesterase 3 inhibitorinhibitorphosphodiesterase 3
Cilostazol is a phosphodiesterase 3 inhibitor which works by inhibiting platelet aggregation and dilating arteries.
Cilostazol is used for the treatment of intermittent claudication.

Heart failure

congestive heart failurecardiac failurechronic heart failure
Serious side effects may include decreased survival in those with heart failure, low platelets, and low white blood cells.
This includes NSAIDS, COX-2 inhibitors, a number of anesthetic agents such as ketamine, thiazolidinediones, some cancer medications, several antiarrhythmic medications, pregabalin, alpha-2 adrenergic receptor agonists, minoxidil, itraconazole, cilostazol, anagrelide, stimulants (e.g., methylphenidate), tricyclic antidepressants, lithium, antipsychotics, dopamine agonists, TNF inhibitors, calcium channel blockers, salbutamol, and tamsulosin.

Antiplatelet drug

antiplateletplatelet aggregation inhibitorantiplatelet agent
Cilostazol is a phosphodiesterase 3 inhibitor which works by inhibiting platelet aggregation and dilating arteries.

Intermittent claudication

claudication intermittensvascular claudication
Cilostazol, sold under the brand name Pletal among others, is a medication used to help the symptoms of intermittent claudication in peripheral vascular disease.
Angiotensin converting enzyme inhibitors, adrenergic agents such as alpha-1 blockers and beta-blockers and alpha-2 agonists, antiplatelet agents (aspirin and clopidogrel), naftidrofuryl, pentoxifylline, and cilostazol (selective PDE3 inhibitor) are used for the treatment of intermittent claudication.

CYP3A4

cytochrome P450 3A43A4cytochrome P450-3A4
Cilostazol is metabolized by CYP3A4 and CYP2C19, two isoenzymes of the cytochrome P450 system.

Phosphodiesterase 3

PDE3PDE3APDE 3
Cilostazol is a selective inhibitor of phosphodiesterase type 3 (PDE 3 ) with therapeutic focus on increasing cAMP.
Cilostazol is approved for treatment of intermittent claudication and is thought to involve inhibition of platelet aggregation and also inhibition of smooth muscle proliferation and vasodilation.

Medication

pharmaceuticalpharmaceuticalspharmaceutical drug
Cilostazol, sold under the brand name Pletal among others, is a medication used to help the symptoms of intermittent claudication in peripheral vascular disease.

Stroke

ischemic strokestrokescerebrovascular accident
It may also be used to prevent stroke.

Thrombocytopenia

low platelet countthrombocytopaenialow platelets
Serious side effects may include decreased survival in those with heart failure, low platelets, and low white blood cells.

Leukopenia

leucopenialow white blood cellslow white blood cell count
Serious side effects may include decreased survival in those with heart failure, low platelets, and low white blood cells.

Generic drug

generic medicationgenericgeneric drugs
It is available as a generic medication.

National Health Service

NHSNational Health Service (NHS)National Health Services
A month supply in the United Kingdom costs the NHS about 5 £ as of 2019.

Headache

headacheschronic headacheheadach
Possible side effects of cilostazol use include headache (the most common), diarrhea, severe heat intolerance, abnormal stools, increased heart rate, and palpitations.

Diarrhea

diarrhoeadiarrheal diseaseschronic diarrhea
Possible side effects of cilostazol use include headache (the most common), diarrhea, severe heat intolerance, abnormal stools, increased heart rate, and palpitations.

Heat intolerance

heat sensitiveSensitivity to heat
Possible side effects of cilostazol use include headache (the most common), diarrhea, severe heat intolerance, abnormal stools, increased heart rate, and palpitations.

Human feces

stoolfecesstools
Possible side effects of cilostazol use include headache (the most common), diarrhea, severe heat intolerance, abnormal stools, increased heart rate, and palpitations.

Tachycardia

fast heart rateincreased heart raterapid heart rate
Possible side effects of cilostazol use include headache (the most common), diarrhea, severe heat intolerance, abnormal stools, increased heart rate, and palpitations.

Palpitations

palpitationheart palpitationsheart palpitation
Possible side effects of cilostazol use include headache (the most common), diarrhea, severe heat intolerance, abnormal stools, increased heart rate, and palpitations.

CYP2C19

2C19CYP2C19*2cytochrome P450 2C19
Cilostazol is metabolized by CYP3A4 and CYP2C19, two isoenzymes of the cytochrome P450 system.

Isozyme

isoenzymeisozymesisoenzymes
Cilostazol is metabolized by CYP3A4 and CYP2C19, two isoenzymes of the cytochrome P450 system.

Cytochrome P450

cytochrome P450 oxidaseP450CYP450
Cilostazol is metabolized by CYP3A4 and CYP2C19, two isoenzymes of the cytochrome P450 system.

Enzyme induction and inhibition

inductioninducersinduce
Drugs that inhibit CYP3A4, such as itraconazole, erythromycin, ketoconazole, and diltiazem, are known to interact with cilostazol.

Itraconazole

Sporanoxitraconacole
Drugs that inhibit CYP3A4, such as itraconazole, erythromycin, ketoconazole, and diltiazem, are known to interact with cilostazol.

Erythromycin

erythromycin estolateerythromycin ethylsuccinateA/T/S
Drugs that inhibit CYP3A4, such as itraconazole, erythromycin, ketoconazole, and diltiazem, are known to interact with cilostazol.