Coactivator (genetics)

coactivatorcoactivatorsco-activatortranscriptional coactivatorco-activatorscoactivationtranscriptional co-activatorstranscriptional coactivatorsco-activationCoactivation (Transcription)
A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a gene or set of genes.wikipedia
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Transcription coregulator

transcriptional coregulatorycoregulatorscoregulatory
A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a gene or set of genes.
Transcription coregulators that activate gene transcription are referred to as coactivators while those that repress are known as corepressors.

Transcription factor

transcription factorsgene transcription factortranscriptional factors
A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a gene or set of genes.
Other proteins such as coactivators, chromatin remodelers, histone acetyltransferases, histone deacetylases, kinases, and methylases are also essential to gene regulation, but lack DNA-binding domains, and therefore are not TFs.

Transcription (biology)

transcriptiontranscribedtranscriptional
A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a gene or set of genes.
Transcription initiation is regulated by additional proteins, known as activators and repressors, and, in some cases, associated coactivators or corepressors, which modulate formation and function of the transcription initiation complex.

CREB-binding protein

CREBBPCREB binding proteinCBP
Examples of coactivators that display HAT activity include CARM1, CBP and EP300.
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors.

EP300

p300Adenoviral E1A-associated protein of 300kDa (p300)E1A protein
Examples of coactivators that display HAT activity include CARM1, CBP and EP300.
On the basis of this function, p300 is called a transcriptional coactivator.

Activator (genetics)

activatortranscriptional activatoractivators
A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a gene or set of genes.

CARM1

CARM-1Protein arginine methyltransferase 4
Examples of coactivators that display HAT activity include CARM1, CBP and EP300.
CARM1 is a secondary coactivator through its association with p160 family (SRC-1, GRIP1, AIB) of coactivators.

TAF1

TAF II 250TAFII250
Cofactors such as TAF1 and BTAF1 can initiate transcription in the presence of an activator (act as a coactivator) and repress basal transcription in the absence of an activator (act as a corepressor).
TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation.

Nuclear receptor coactivator 3

NCOA3ACTRSRC3
For example, the steroid receptor coactivator (SCR) NCOA3 is often overexpressed in breast cancer, so the development of an inhibitor molecule that targets this coactivator and decreases its expression could be used as a potential treatment for breast cancer.
NCOA3 is a transcriptional coactivator protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity.

Corepressor

corepressorsco-repressorco-repressors
Many coactivators also function as corepressors under certain circumstances.
In the absence of corepressors and in the presence of coactivators, transcription factors upregulate gene expression.

Nuclear receptor

nuclear receptorsnuclearmechanism
Ligand binding to the nuclear receptor causes dissociation of corepressor and recruitment of coactivator proteins.

BCL3

Bcl-3
This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers.

Nuclear receptor coactivator 2

NCOA2GRIP-1SRC2
GRIP1 is a transcriptional co-activator of the glucocorticoid receptor and interferon regulatory factor 1 (IRF1).

Ran (protein)

RanRanGTPRan (biology)
RAN is an androgen receptor (AR) coactivator (ARA24) that binds differentially with different lengths of polyglutamine within the androgen receptor.

Gene

genesnumber of genesgene sequence
A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a gene or set of genes.

DNA-binding domain

DNA binding domainDNA bindingDNA-binding
The activator contains a DNA binding domain that binds either to a DNA promoter site or a specific DNA regulatory sequence called an enhancer.

Promoter (genetics)

promoterpromoterspromoter region
The activator contains a DNA binding domain that binds either to a DNA promoter site or a specific DNA regulatory sequence called an enhancer.

Regulatory sequence

regulatory elementsregulatory sequencesregulatory regions
The activator contains a DNA binding domain that binds either to a DNA promoter site or a specific DNA regulatory sequence called an enhancer.

Enhancer (genetics)

enhancerenhancersgene enhancer
The activator contains a DNA binding domain that binds either to a DNA promoter site or a specific DNA regulatory sequence called an enhancer.

Gene expression

expressionexpressedexpress
Binding of the activator-coactivator complex increases the speed of transcription by recruiting general transcription machinery to the promoter, therefore increasing gene expression.

Histone acetyltransferase

histone acetylationhistone acetyltransferasesHAT
Some coactivators also have histone acetyltransferase (HAT) activity.

Histone

histoneshistone modificationhistone modifications
HATs form large multiprotein complexes that weaken the association of histones to DNA by acetylating the N-terminal histone tail.

Acetylation

acetylateddeacetylationN-terminal acetylation
HATs form large multiprotein complexes that weaken the association of histones to DNA by acetylating the N-terminal histone tail.

N-terminus

N-terminalN terminusN-
HATs form large multiprotein complexes that weaken the association of histones to DNA by acetylating the N-terminal histone tail.