Cocaine

cokecocaine traffickingcrackcrack cocaineblowcocaine hydrochloridecocaine tradecocaine spoonpowder cocainecocaine use
Cocaine, also known as coke, is a strong stimulant mostly used as a recreational drug.wikipedia
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Stimulant

psychostimulantstimulantspsychostimulants
Cocaine, also known as coke, is a strong stimulant mostly used as a recreational drug.
It is estimated that the percentage of the population that has abused amphetamine-type stimulants (e.g., amphetamine, methamphetamine, MDMA, etc.) and cocaine combined is between 0.8% and 2.1%.

Recreational drug use

recreational drugdrug usedrugs
Cocaine, also known as coke, is a strong stimulant mostly used as a recreational drug.
What controlled substances are considered illegal drugs varies by country, but usually includes methamphetamines, heroin, cocaine, LSD, psilocybin mushrooms, MDMA and club drugs.

Crack cocaine

crackcrack-cocainecrack pipe
With further processing crack cocaine can be produced from cocaine.
Crack cocaine, also known simply as crack, is a free base form of cocaine that can be smoked.

Myocardial infarction

heart attackheart attacksacute myocardial infarction
Its use also increases the risk of stroke, myocardial infarction, lung problems in those who smoke it, blood infections, and sudden cardiac death.
The complete blockage of a coronary artery caused by a rupture of an atherosclerotic plaque is usually the underlying mechanism of an MI. MIs are less commonly caused by coronary artery spasms, which may be due to cocaine, significant emotional stress, and extreme cold, among others.

Single Convention on Narcotic Drugs

Single Convention on Narcotic Drugs 1961Schedule IUN conventions
Since 1961, the international Single Convention on Narcotic Drugs has required countries to make recreational use of cocaine a crime.
Earlier treaties had only controlled opium, coca, and derivatives such as morphine, heroin and cocaine.

Euphoria

euphoriceuphorianthigh
Mental effects may include loss of contact with reality, an intense feeling of happiness, or agitation.
Sigmund Freud's 1884 monograph Über Coca described (his own) consumption of cocaine producing "the normal euphoria of a healthy person", while about 1890 the German neuropsychiatrist Carl Wernicke lectured about the "abnormal euphoria" in patients with mania.

Tachycardia

fast heart rateincreased heart raterapid heart rate
Physical symptoms may include a fast heart rate, sweating, and large pupils.
Cocaine

Stroke

strokesischemic strokecerebrovascular accident
Its use also increases the risk of stroke, myocardial infarction, lung problems in those who smoke it, blood infections, and sudden cardiac death.
Users of stimulants, such as cocaine and methamphetamine are at a high risk for ischemic strokes.

Serotonin–norepinephrine–dopamine reuptake inhibitor

serotonin-norepinephrine-dopamine reuptake inhibitortriple reuptake inhibitorSNDRI
Cocaine acts by inhibiting the reuptake of serotonin, norepinephrine, and dopamine.
Cocaine is a naturally occurring SNDRI with a fast onset and short duration (about two hours) that is widely encountered as a drug of abuse.

Speedball (drug)

speedballspeedballscocaine and heroin
An injected mixture of cocaine and heroin, known as "speedball" is a particularly dangerous combination, as the converse effects of the drugs actually complement each other, but may also mask the symptoms of an overdose.
Speedball (or powerball) is a mixture of cocaine (a stimulant) with heroin or morphine (a depressant), taken intravenously or by insufflation.

Anesthetic

anaestheticanestheticsanaesthetics
Topical cocaine can be used as a local numbing agent to help with painful procedures in the mouth or nose.
Ester local anesthetics (such as procaine, amethocaine, cocaine, benzocaine, tetracaine) are generally unstable in solution and fast-acting, are rapidly metabolised by cholinesterases in the blood plasma and liver, and more commonly induce allergic reactions.

Psychoactive drug

psychoactivepsychotropicdrug
Given the slow rate of absorption, maximum physiological and psychotropic effects are attained approximately 60 minutes after cocaine is administered by ingestion.
Examples: amphetamine, caffeine, cocaine, nicotine

Drug injection

intravenous drugintravenous drug useinjecting drug user
Drug injection by turning the drug into a solution provides the highest blood levels of drug in the shortest amount of time.
This act is often colloquially referred to as "slamming", "shooting [up]", “smashing”, "banging", "pinning", or "jacking-up", often depending on the specific drug subculture in which the term is used (i.e. heroin, cocaine, or methamphetamine).

Hyperthermia

heat stressheat strokehyperthermic
High doses can result in very high blood pressure or body temperature.
Various stimulant drugs, including amphetamines and cocaine, and hallucinogenic drugs, including PCP, LSD, and MDMA can produce hyperthermia as an adverse effect.

Psychosis

psychoticpsychosespsychotic break
Mental effects may include loss of contact with reality, an intense feeling of happiness, or agitation.
Drugs commonly alleged to induce psychotic symptoms include alcohol, cannabis, cocaine, amphetamines, cathinones, psychedelic drugs (such as LSD and psilocybin), κ-opioid receptor agonists (such as enadoline and salvinorin A) and NMDA receptor antagonists (such as phencyclidine and ketamine).

Hypertension

high blood pressurehypertensivearterial hypertension
High doses can result in very high blood pressure or body temperature.
Other causes of secondary hypertension include obesity, sleep apnea, pregnancy, coarctation of the aorta, excessive eating of liquorice, excessive drinking of alcohol, and certain prescription medicines, herbal remedies, and illegal drugs such as cocaine and methamphetamine.

Prohibition of drugs

illegal drugdrug prohibitionprohibition
Cocaine is the second most frequently used illegal drug globally, after cannabis.
Home Office control was extended to include raw opium, morphine, cocaine, ecogonine and heroin.

John Belushi

JohnJoliet" Jake BluesBelushi
It has been responsible for numerous deaths, including celebrities such as comedians/actors John Belushi and Chris Farley, Mitch Hedberg, River Phoenix, grunge singer Layne Staley and actor Philip Seymour Hoffman.
In 1982, Belushi died from combined drug intoxication caused by an injection of a heroin and cocaine mixture, known as a speedball.

Psychomotor agitation

agitationrestlessnessexcitement
Mental effects may include loss of contact with reality, an intense feeling of happiness, or agitation.
Side effects of drugs like cocaine or methylphenidate

Heroin

diamorphinediacetylmorphinesmack
An injected mixture of cocaine and heroin, known as "speedball" is a particularly dangerous combination, as the converse effects of the drugs actually complement each other, but may also mask the symptoms of an overdose.
In 1964 the Brain Committee recommended that only selected approved doctors working at approved specialised centres be allowed to prescribe diamorphine and benzoylmethylecgonine (cocaine) to users.

Cocaine dependence

cocaine addictioncocaine addictcocaine abuse
After a short period of use, there is a high risk that dependence will occur.
Cocaine dependence is a psychological desire to use cocaine regularly.

Cannabis (drug)

marijuanacannabispot
Cocaine is the second most frequently used illegal drug globally, after cannabis.
According to DSM-V criteria, 9% of those who are exposed to cannabis develop cannabis use disorder, compared to 20% for cocaine, 23% for alcohol and 68% for nicotine.

Moffett's solution

An alternative method of administration for ENT surgery is mixed with adrenaline and sodium bicarbonate, as Moffett's solution.
Moffett's solution is a mixture of adrenaline, sodium bicarbonate and cocaine that is used to provide topical analgesia and vasoconstriction during ear, nose, and throat surgery, especially for operations on the nose.

Relapse

recurrencerelapsingrecurrent
They self-administer cocaine at lower doses than control, but have a greater likelihood of relapse when the drug is withheld.
The availability of the dopamine receptor D2 plays a role in self-administration and the reinforcing effects of cocaine and other stimulants.

Drug Enforcement Administration

DEAD.E.A.DEA agent
Despite this, the DEA seized several shipments in Hawaii, Chicago, Georgia, and several locations on the East Coast of the United States, and the product was removed from the shelves.
One recent study by the DEA showed that the price of cocaine and methamphetamine is the highest it has ever been while the quality of both is at its lowest point ever.