Cocaine

cokecocaine traffickingcrackcrack cocaineblowcocaine hydrochloridecocaine spooncocaine tradepowder cocainecocaine use
Cocaine, also known as coke, is a strong stimulant most frequently used as a recreational drug.wikipedia
3,937 Related Articles

Stimulant

stimulantspsychostimulantpsychostimulants
Cocaine, also known as coke, is a strong stimulant most frequently used as a recreational drug.
It is estimated that the percentage of the population that has abused amphetamine-type stimulants (e.g., amphetamine, methamphetamine, MDMA, etc.) and cocaine combined is between 0.8% and 2.1%.

Recreational drug use

recreational drugdrug userecreational drugs
Cocaine, also known as coke, is a strong stimulant most frequently used as a recreational drug.
What controlled substances are considered illegal drugs varies by country, but usually includes methamphetamine, heroin, cocaine, LSD, psilocybin mushrooms, MDMA and club drugs.

Crack cocaine

crackcrack-cocainecrack pipe
With further processing, crack cocaine can be produced from cocaine.
Crack cocaine, also known simply as crack or rock, is a free base form of cocaine that can be smoked.

Myocardial infarction

heart attackheart attacksacute myocardial infarction
Its use also increases the risk of stroke, myocardial infarction, lung problems in those who smoke it, blood infections, and sudden cardiac death.
MIs are less commonly caused by coronary artery spasms, which may be due to cocaine, significant emotional stress and extreme cold, among others.

Single Convention on Narcotic Drugs

Single Convention on Narcotic Drugs 1961Schedule ISingle Convention on Narcotic Drugs of 1961
Since 1961, the international Single Convention on Narcotic Drugs has required countries to make recreational use of cocaine a crime.
Earlier treaties had only controlled opium, coca, and derivatives such as morphine, heroin and cocaine.

Euphoria

euphoriceuphorianthigh
Mental effects may include loss of contact with reality, an intense feeling of happiness, or agitation.
Sigmund Freud's 1884 monograph Über Coca described (his own) consumption of cocaine producing "the normal euphoria of a healthy person", while about 1890 the German neuropsychiatrist Carl Wernicke lectured about the "abnormal euphoria" in patients with mania.

Tachycardia

fast heart rateincreased heart raterapid heart rate
Physical symptoms may include a fast heart rate, sweating, and large pupils.
This is the basis for the so-called fight-or-flight response, but such stimulation can also be induced by stimulants such as ephedrine, amphetamines or cocaine.

Stroke

ischemic strokestrokescerebrovascular accident
Its use also increases the risk of stroke, myocardial infarction, lung problems in those who smoke it, blood infections, and sudden cardiac death.
Users of stimulants, such as cocaine and methamphetamine are at a high risk for ischemic strokes.

Serotonin–norepinephrine–dopamine reuptake inhibitor

serotonin-norepinephrine-dopamine reuptake inhibitortriple reuptake inhibitorSNDRI
Cocaine acts by inhibiting the reuptake of serotonin, norepinephrine, and dopamine.
Cocaine is a naturally occurring SNDRI with a fast onset and short duration (about two hours) that is widely encountered as a drug of abuse.

Speedball (drug)

speedballspeedballscocaine and heroin
An injected mixture of cocaine and heroin, known as "speedball" is a particularly dangerous combination, as the converse effects of the drugs actually complement each other, but may also mask the symptoms of an overdose.
Speedball (or powerball) is a mixture of cocaine (a stimulant) with heroin or morphine (an opioid) or sometimes benzodiazepine, taken intravenously or by insufflation.

Anesthetic

anaestheticanestheticsanaesthetics
Topical cocaine can be used as a local numbing agent to help with painful procedures in the mouth or nose.
Ester local anesthetics (such as procaine, amethocaine, cocaine, benzocaine, tetracaine) are generally unstable in solution and fast-acting, are rapidly metabolised by cholinesterases in the blood plasma and liver, and more commonly induce allergic reactions.

Psychoactive drug

psychoactivepsychotropicdrug
Given the slow rate of absorption, maximum physiological and psychotropic effects are attained approximately 60 minutes after cocaine is administered by ingestion.
Alcohol and caffeine are ingested in beverage form; nicotine and cannabis are smoked or vaped; peyote and psilocybin mushrooms are ingested in botanical form or dried; and crystalline drugs such as cocaine and methamphetamine are usually insufflated (inhaled or "snorted").

Psychosis

psychoticpsychosespsychotic break
Mental effects may include loss of contact with reality, an intense feeling of happiness, or agitation.
Drugs commonly alleged to induce psychotic symptoms include alcohol, cannabis, cocaine, amphetamines, cathinones, psychedelic drugs (such as LSD and psilocybin), κ-opioid receptor agonists (such as enadoline and salvinorin A) and NMDA receptor antagonists (such as phencyclidine and ketamine).

Drug injection

intravenous drugintravenous drug useinjecting drug user
Drug injection by turning the drug into a solution provides the highest blood levels of drug in the shortest amount of time.
This act is often colloquially referred to as "slamming", "shooting [up]", “smashing”, "banging", "pinning", or "jacking-up", often depending on the specific drug subculture in which the term is used (i.e. heroin, cocaine, or methamphetamine).

Hyperthermia

heat stresshyperthermicheat stroke
High doses can result in very high blood pressure or body temperature.

Prohibition of drugs

illegal drugsillegal drugdrug prohibition
Cocaine is the second most frequently used illegal drug globally, after cannabis.
Home Office control was extended to include raw opium, morphine, cocaine, ecogonine and heroin.

Hypertension

high blood pressurehypertensivearterial hypertension
High doses can result in very high blood pressure or body temperature.
Other causes of secondary hypertension include obesity, sleep apnea, pregnancy, coarctation of the aorta, excessive eating of liquorice, excessive drinking of alcohol, certain prescription medicines, herbal remedies, and stimulants such as cocaine and methamphetamine.

John Belushi

Judith Belushi PisanoJohnJoliet" Jake Blues
It has been responsible for numerous deaths, including celebrities such as comedians/actors John Belushi and Chris Farley, Mitch Hedberg, River Phoenix, grunge singer Layne Staley and actor Philip Seymour Hoffman.
In 1982, Belushi died from combined drug intoxication caused by a woman who injected him with a mixture of heroin and cocaine known as a speedball.

Heroin

diamorphinediacetylmorphinesmack
An injected mixture of cocaine and heroin, known as "speedball" is a particularly dangerous combination, as the converse effects of the drugs actually complement each other, but may also mask the symptoms of an overdose.
In 1964 the Brain Committee recommended that only selected approved doctors working at approved specialised centres be allowed to prescribe diamorphine and benzoylmethylecgonine (cocaine) to users.

Psychomotor agitation

agitationrestlessnessexcitement
Mental effects may include loss of contact with reality, an intense feeling of happiness, or agitation.

Cannabis (drug)

marijuanacannabispot
Cocaine is the second most frequently used illegal drug globally, after cannabis.
According to DSM-V criteria, 9% of those who are exposed to cannabis develop cannabis use disorder, compared to 20% for cocaine, 23% for alcohol and 68% for nicotine.

Mydriasis

dilated pupilsmydriaticpupil dilation
Physical symptoms may include a fast heart rate, sweating, and large pupils.

Cocaine dependence

cocaine addictioncocaine abusecocaine addict
After a short period of use, there is a high risk that dependence will occur.
Cocaine dependence is a psychological desire to use cocaine regularly.

Moffett's solution

An alternative method of administration for ENT surgery is mixed with adrenaline and sodium bicarbonate, as Moffett's solution.
Moffett's solution is a mixture of adrenaline, sodium bicarbonate and cocaine that is used to provide topical analgesia and vasoconstriction during ear, nose, and throat surgery, especially for operations on the nose.

Adulterant

adulterationadulteratedfood adulteration
Nosebleeds after cocaine insufflation are due to irritation and damage of mucus membranes by foreign particles and adulterants and not the cocaine itself; as a vasoconstrictor, cocaine acts to reduce bleeding.