The succinate dehydrogenase complex showing several cofactors, including flavin, iron–sulfur centers, and heme.
A 1990 phylogenetic tree linking all major groups of living organisms to the LUCA (the black trunk at the bottom), based on ribosomal RNA sequence data.
A simple [Fe2S2] cluster containing two iron atoms and two sulfur atoms, coordinated by four protein cysteine residues.
LUCA systems and environment
The redox reactions of nicotinamide adenine dinucleotide.
2005 tree of life showing horizontal gene transfers between branches, giving rise to an interconnected network rather than a tree
The LUCA used the Wood–Ljungdahl or reductive acetyl–CoA pathway to fix carbon.
A tree of life, like this one from Charles Darwin's notebooks c. July 1837, implies a single common ancestor at its root (labelled "1"), as Darwin noted.

The cofactors also reveal "dependence upon transition metals, flavins, S-adenosyl methionine, coenzyme A, ferredoxin, molybdopterin, corrins and selenium. Its genetic code required nucleoside modifications and S-adenosylmethionine-dependent methylations."

- Last universal common ancestor

At least some of the current set of cofactors may, therefore, have been present in the last universal ancestor, which lived about 4 billion years ago.

- Cofactor (biochemistry)
The succinate dehydrogenase complex showing several cofactors, including flavin, iron–sulfur centers, and heme.

0 related topics with Alpha

Overall