Collecting duct system

collecting ductcortical collecting ductcollecting ductsmedullary collecting ductinner medullary collecting ductcollecting tubulescollecting tubulecortical collecting ductsIntercalated cellsouter medullary collecting duct
The collecting duct system of the kidney consists of a series of tubules and ducts that physically connect nephrons to a minor calyx or directly to the renal pelvis.wikipedia
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Kidney

kidneysrenalkidney disorder
The collecting duct system of the kidney consists of a series of tubules and ducts that physically connect nephrons to a minor calyx or directly to the renal pelvis.
Part of the renal cortex, a medullary ray is a collection of renal tubules that drain into a single collecting duct.

Aldosterone

receptors, aldosteroneadrenoglomerulotropin
The collecting duct system participates in electrolyte and fluid balance through reabsorption and excretion, processes regulated by the hormones aldosterone and vasopressin (antidiuretic hormone). Aldosterone determines expression of sodium channels (especially the ENaC).
It does so primarily by acting on the mineralocorticoid receptors in the distal tubules and collecting ducts of the nephron.

Connecting tubule

collecting tubulerenal collecting tubule
In the kidney, the connecting tubule (CNT, or junctional tubule, or arcuate renal tubule) is a tubular segment of the renal collecting duct system that connects the distal convoluted tubule to the cortical collecting duct.

Papillary duct

Duct of Bellinipapillary ductsBellini's ducts
Papillary ducts represent the most distal portion of the collecting duct.

Nephron

renal tubulenephronsrenal tubules
The collecting duct system of the kidney consists of a series of tubules and ducts that physically connect nephrons to a minor calyx or directly to the renal pelvis. It is adjacent to the distal convoluted tubule, the most distal segment of the renal tubule.
The tubule has five anatomically and functionally different parts: the proximal tubule, which has a convoluted section the proximal convoluted tubule followed by a straight section (proximal straight tubule); the loop of Henle, which has two parts, the descending loop of Henle ("descending loop") and the ascending loop of Henle ("ascending loop"); the distal convoluted tubule ("distal loop"); the connecting tubule, and the collecting ducts.

Metanephrogenic blastema

Metanephric blastemametanephric mesenchyme
The connecting tubule derives from the metanephric blastema, but the rest of the system derives from the ureteric bud.
The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.

Renal medulla

renal papillamedullarenal pyramid
The "cortical collecting ducts" receive filtrate from multiple initial collecting tubules and descend into the renal medulla to form medullary collecting ducts.
Flow continues through the renal tubules, including the proximal tubule, the Loop of Henle, through the distal tubule and finally leaves the kidney by means of the collecting duct, leading to the renal pelvis, the dilated portion of the ureter.

Epithelial sodium channel

ENaCepithelial sodium channelsEpithelial Na + channel family
Aldosterone determines expression of sodium channels (especially the ENaC).
It is involved primarily in the reabsorption of sodium ions at the collecting ducts of the kidney's nephrons.

Fluid balance

diuresiseuvolemicfluid
The collecting duct system participates in electrolyte and fluid balance through reabsorption and excretion, processes regulated by the hormones aldosterone and vasopressin (antidiuretic hormone).
Among other actions, it causes renal tubules (i.e. the distal convoluted tubules and the cortical collecting ducts) to reabsorb more sodium and water from the urine.

Ureteric bud

metanephric
The connecting tubule derives from the metanephric blastema, but the rest of the system derives from the ureteric bud.

Renal tubular acidosis

acid excretiondistal renal tubular acidosiskidney problems
Damage to the α-intercalated cell's ability to secrete acid can result in distal renal tubular acidosis (RTA type I, classical RTA)(reference).
Distal RTA is characterized by a failure of H+ secretion into lumen of nephron by the alpha intercalated cells of the medullary collecting duct of the distal nephron.

Band 3 anion transport protein

Band 3SLC4A1anion exchange protein 1, erythrocyte
Band 3 is present in the basolateral face of the α-intercalated cells of the collecting ducts of the nephron, which are the main acid-secreting cells of the kidney.

Vasopressin

antidiuretic hormoneADHarginine vasopressin
The collecting duct system participates in electrolyte and fluid balance through reabsorption and excretion, processes regulated by the hormones aldosterone and vasopressin (antidiuretic hormone). Vasopressin determines the expression of aquaporin channels that provide a physical pathway for water to pass through the principal cells.

Aquaporin

aquaporinsaquaporin 5water channels
Vasopressin determines the expression of aquaporin channels that provide a physical pathway for water to pass through the principal cells.

Pendrin

SLC26A4
Pendrin is also expressed in the kidney, and has been localized to the apical membrane of a population of intercalated cells in the cortical collecting duct where it is involved in bicarbonate secretion.

Renal calyx

minor calyxrenal calycescalyces
The collecting duct system of the kidney consists of a series of tubules and ducts that physically connect nephrons to a minor calyx or directly to the renal pelvis.

Renal pelvis

pyelo-kidney pelvispelvic
The collecting duct system of the kidney consists of a series of tubules and ducts that physically connect nephrons to a minor calyx or directly to the renal pelvis.

Electrolyte

electrolyteselectrolyticionic solution
The collecting duct system participates in electrolyte and fluid balance through reabsorption and excretion, processes regulated by the hormones aldosterone and vasopressin (antidiuretic hormone).

Hormone

hormoneshormonalprohormone
The collecting duct system participates in electrolyte and fluid balance through reabsorption and excretion, processes regulated by the hormones aldosterone and vasopressin (antidiuretic hormone).

Renal corpuscle

vascular poleMalpighian BodiesMalpighian corpuscles
With respect to the renal corpuscle, the "connecting tubule" is the most proximal part of the collecting duct system.

Distal convoluted tubule

distal tubuledistal convoluted tubulesdistal tubules
It is adjacent to the distal convoluted tubule, the most distal segment of the renal tubule.

Descending limb of loop of Henle

descending limbthin descending limb of the loop of Henlethin descending loop of Henle
It reaches the level of the renal medulla where the thin descending limb of loop of Henle borders with the thick ascending limb of loop of Henle

Ascending limb of loop of Henle

thick ascending limbthin ascending limbthick ascending limb of loop of Henle
It reaches the level of the renal medulla where the thin descending limb of loop of Henle borders with the thick ascending limb of loop of Henle

Sodium channel

voltage-gated sodium channelsodium channelsvoltage-gated sodium channels
The principal cell mediates the collecting duct's influence on sodium and potassium balance via sodium channels and potassium channels located on the cell's apical membrane.

Potassium channel

potassium channelspotassiumpotassium ion channels
The principal cell mediates the collecting duct's influence on sodium and potassium balance via sodium channels and potassium channels located on the cell's apical membrane.