Location and appearance of two example colorectal tumors
Micrograph of the small intestine mucosa showing the intestinal glands - bottom 1/3 of image. H&E stain.
Longitudinally opened freshly resected colon segment showing a cancer and four polyps. Plus a schematic diagram indicating a likely field defect (a region of tissue that precedes and predisposes to the development of cancer) in this colon segment. The diagram indicates sub-clones and sub-sub-clones that were precursors to the tumors.
Colonic crypts (intestinal glands) within four tissue sections. In panel A, the bar shows 100 µm and allows an estimate of the frequency of crypts in the colonic epithelium. Panel B includes three crypts in cross-section, each with one segment deficient for CCOI expression and at least one crypt, on the right side, undergoing fission into two crypts. Panel C shows, on the left side, a crypt fissioning into two crypts. Panel D shows typical small clusters of two and three CCOI deficient crypts (the bar shows 50 µm). The images were made from original photomicrographs, but panels A, B and D were also included in an article
Colon cancer with extensive metastases to the liver
Micrograph showing intestinal crypt branching, a histopathological finding of chronic colitides. H&E stain.
Relative incidence of various histopathological types of colorectal cancer. The vast majority of colorectal cancers are adenocarcinomas.
Micrograph showing crypt inflammation. H&E stain.
Micrograph of colorectal adenocarcinoma, showing "dirty necrosis".
A diagram of a local resection of early stage colon cancer
A diagram of local surgery for rectal cancer
Colon and rectum cancer deaths per million persons in 2012

Loss of proliferation control in the crypts is thought to lead to colorectal cancer.

- Intestinal gland

The mutations can be inherited or acquired, and most probably occur in the intestinal crypt stem cell.

- Colorectal cancer
Location and appearance of two example colorectal tumors

3 related topics with Alpha

Overall

Endoscopic image of a colon affected by ulcerative colitis. The internal surface of the colon is blotchy and broken in places. Mild-moderate disease.

Ulcerative colitis

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Long-term condition that results in inflammation and ulcers of the colon and rectum.

Long-term condition that results in inflammation and ulcers of the colon and rectum.

Endoscopic image of a colon affected by ulcerative colitis. The internal surface of the colon is blotchy and broken in places. Mild-moderate disease.
Classification of colitis, often used in defining the extent of involvement of ulcerative colitis, with proctitis (blue), proctosigmoiditis (yellow), left sided colitis (orange) and pancolitis (red). All classes extend distally to the end of the rectum.
Gross pathology of normal colon (left) and severe ulcerative colitis (right), forming pseudopolyps (smaller than the cobblestoning typically seen in Crohn's disease), over a continuous area (rather than skip lesions of Crohn's disease), and with a relatively gradual transition from normal colon (while Crohn's is typically more abrupt).
Aphthous ulcers involving the tongue, lips, palate, and pharynx.
Pyoderma gangrenosum with large ulcerations affecting the back.
Endoscopic image of ulcerative colitis affecting the left side of the colon. The image shows confluent superficial ulceration and loss of mucosal architecture. Crohn's disease may be similar in appearance, a fact that can make diagnosing UC a challenge.
H&E stain of a colonic biopsy showing a crypt abscess, a classic finding in ulcerative colitis
Colonic pseudopolyps of a person with intractable UC, colectomy specimen
Biopsy sample (H&E stain) that demonstrates marked lymphocytic infiltration (blue/purple) of the intestinal mucosa and architectural distortion of the crypts.

Complications may include abnormal dilation of the colon (megacolon), inflammation of the eye, joints, or liver, and colon cancer.

Histologic findings in ulcerative colitis includes: distortion of crypt architecture, crypt abscesses, and inflammatory cells in the mucosa (lymphocytes, plasma cells, and granulocytes).

The three most common sites of intestinal involvement in Crohn's disease (left) compared to the areas affected by colitis ulcerosa (right).

Crohn's disease

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Type of inflammatory bowel disease that may affect any segment of the gastrointestinal tract.

Type of inflammatory bowel disease that may affect any segment of the gastrointestinal tract.

The three most common sites of intestinal involvement in Crohn's disease (left) compared to the areas affected by colitis ulcerosa (right).
An aphthous ulcer on the mucous membrane of the mouth in Crohn's disease.
A single lesion of erythema nodosum
Endoscopic image of colon cancer identified in the sigmoid colon on screening colonoscopy for Crohn's disease
NOD2 protein model with schematic diagram. Two N-terminal CARD domains (red) connected via helical linker (blue) with central NBD domain (green). At C-terminus LRR domain (cyan) is located. Additionally, some mutations which are associated with certain disease patterns in Crohn's disease are marked in red wire representation.
Distribution of gastrointestinal Crohn's disease.
Endoscopic image of Crohn's colitis showing deep ulceration
CT scan showing Crohn's disease in the fundus of the stomach
Endoscopic biopsy showing granulomatous inflammation of the colon in a case of Crohn's disease.
Section of colectomy showing transmural inflammation
Resected ileum from a person with Crohn's disease

Bowel obstruction may occur as a complication of chronic inflammation, and those with the disease are at greater risk of colon cancer and small bowel cancer.

These neutrophils, along with mononuclear cells, may infiltrate the crypts, leading to inflammation (crypititis) or abscess (crypt abscess).

Front of abdomen, showing the large intestine, with the stomach and small intestine in gray.

Large intestine

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Last part of the gastrointestinal tract and of the digestive system in vertebrates.

Last part of the gastrointestinal tract and of the digestive system in vertebrates.

Front of abdomen, showing the large intestine, with the stomach and small intestine in gray.
Illustration of the large intestine.
Inner diameters of colon sections
Colonic crypts (intestinal glands) within four tissue sections. The cells have been stained to show a brown-orange color if the cells produce the mitochondrial protein cytochrome c oxidase subunit I (CCOI), and the nuclei of the cells (located at the outer edges of the cells lining the walls of the crypts) are stained blue-gray with haematoxylin. Panels A, B were cut across the long axes of the crypts and panels C, D were cut parallel to the long axes of the crypts. In panel A the bar shows 100 µm and allows an estimate of the frequency of crypts in the colonic epithelium. Panel B includes three crypts in cross-section, each with one segment deficient for CCOI expression and at least one crypt, on the right side, undergoing fission into two crypts. Panel C shows, on the left side, a crypt fissioning into two crypts. Panel D shows typical small clusters of two and three CCOI deficient crypts (the bar shows 50 µm). The images were made from original photomicrographs, but panels A, B and D were also included in an article and illustrations were published with Creative Commons Attribution-Noncommercial License allowing re-use.
Histological section.
Colonoscopy image, splenic flexure,
normal mucosa. You can see spleen through it : the black part
Micrograph of normal large instestinal crypts.
Anatomy of normal large intestinal crypts
Intestines
Colon. Deep dissection. Anterior view.

The invaginations are called the intestinal glands or colonic crypts.

Bacteroides are implicated in the initiation of colitis and colon cancer.