A report on Colorectal cancer

Location and appearance of two example colorectal tumors
Longitudinally opened freshly resected colon segment showing a cancer and four polyps. Plus a schematic diagram indicating a likely field defect (a region of tissue that precedes and predisposes to the development of cancer) in this colon segment. The diagram indicates sub-clones and sub-sub-clones that were precursors to the tumors.
Colon cancer with extensive metastases to the liver
Relative incidence of various histopathological types of colorectal cancer. The vast majority of colorectal cancers are adenocarcinomas.
Micrograph of colorectal adenocarcinoma, showing "dirty necrosis".
A diagram of a local resection of early stage colon cancer
A diagram of local surgery for rectal cancer
Colon and rectum cancer deaths per million persons in 2012

Development of cancer from the colon or rectum (parts of the large intestine).

- Colorectal cancer
Location and appearance of two example colorectal tumors

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The Jews in Central Europe (1881)

Ashkenazi Jews

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Ashkenazi Jews (יְהוּדֵי אַשְׁכְּנַז, ; אַשכּנזישע ייִדן), also known as Ashkenazic Jews or Ashkenazim, are a Jewish diaspora population who coalesced in the Holy Roman Empire around the end of the first millennium CE.

Ashkenazi Jews (יְהוּדֵי אַשְׁכְּנַז, ; אַשכּנזישע ייִדן), also known as Ashkenazic Jews or Ashkenazim, are a Jewish diaspora population who coalesced in the Holy Roman Empire around the end of the first millennium CE.

The Jews in Central Europe (1881)
The Polish-Lithuanian Commonwealth at its greatest extent.
Jews from Worms (Germany) wearing the mandatory yellow badge.
The example of the chevra kadisha, the Jewish burial society, Prague, 1772

Healthcare professionals are often taught to consider those of Ashkenazi descent to be at increased risk for colon cancer.

National Colon Cancer Awareness Month

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National Colon Cancer Awareness Month is an annual celebration observed in the United States during the month of March, to increase awareness of colorectal cancer.

Celecoxib

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COX-2 inhibitor and nonsteroidal anti-inflammatory drug .

COX-2 inhibitor and nonsteroidal anti-inflammatory drug .

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The use of celecoxib to reduce the risk of colorectal cancer has been investigated, but neither celecoxib nor any other drug is indicated for this use.

The Cancer Genome Atlas

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Project to catalogue the genetic mutations responsible for cancer using genome sequencing and bioinformatics.

Project to catalogue the genetic mutations responsible for cancer using genome sequencing and bioinformatics.

Cancer types selected for study byTCGA included: lung squamous cell carcinoma, kidney papillary carcinoma, clear cell kidney carcinoma, breast ductal carcinoma, renal cell carcinoma, cervical cancer (squamous), colon adenocarcinoma, stomach adenocarcinoma, rectal carcinoma, hepatocellular carcinoma, Head and neck (oral) squamous cell carcinoma, thyroid carcinoma, bladder urothelial carcinoma – nonpapillary, uterine corpus (endometrial carcinoma), pancreatic ductal adenocarcinoma, acute myeloid leukemia, prostate adenocarcinoma, lung adenocarcinoma, cutaneous melanoma, breast lobular carcinoma and lower grade glioma, esophageal carcinoma, ovarian serous cystadenocarcinoma, lung squamous cell carcinoma, adrenocortical carcinoma, Diffuse Large B-cell lymphoma, paraganglioma & pheochromocytoma, cholangiocarcinoma, uterine carcinosarcoma, uveal melanoma, thymoma, sarcoma, mesothelioma, and testicular germ cell cancer.

HSPA1A

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Protein that in humans is encoded by the HSPA1A gene.

Protein that in humans is encoded by the HSPA1A gene.

In particular, overexpression of HSP72 has been linked to the development some cancers, such as hepatocellular carcinoma, gastric cancers, colon cancers, breast cancers, and lung cancers, which led to its use as a prognostic marker for these cancers.

RBM3

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Protein that in humans is encoded by the RBM3 gene.

Protein that in humans is encoded by the RBM3 gene.

Based on patient survival data, high levels of RBM3 protein in tumor cells is a favourable prognostic biomarker in colorectal cancer.