Congenital hypothyroidism

a lack of a functioning thyroid at birthcongenitalcongenital cretinismhypothyroidismNeonatal hypothyroidism
Congenital hypothyroidism (CH) is a condition of thyroid hormone deficiency present at birth.wikipedia
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Hypothyroidism

hypothyroidhypo-underactive thyroid
If untreated for several months after birth, severe congenital hypothyroidism can lead to growth failure and permanent intellectual disability.
Less common causes include: previous treatment with radioactive iodine, injury to the hypothalamus or the anterior pituitary gland, certain medications, a lack of a functioning thyroid at birth, or previous thyroid surgery.

Intellectual disability

mental retardationintellectually disabledintellectual disabilities
If untreated for several months after birth, severe congenital hypothyroidism can lead to growth failure and permanent intellectual disability.

Newborn screening

neonatal screeningscreening of newbornsNewborn Screening Program
Because the treatment is simple, effective, and inexpensive, nearly all of the developed world practices newborn screening to detect and treat congenital hypothyroidism in the first weeks of life.
Congenital hypothyroidism was the second disease widely added in the 1970s.

Congenital iodine deficiency syndrome

cretinismcretincretins
It is now deprecated; ICD-10 uses "congenital iodine deficiency syndrome" with additional specifiers for the various types.
Congenital iodine deficiency syndrome, also known as cretinism, is a condition of severely stunted physical and mental growth owing to untreated congenital deficiency of thyroid hormone, (congenital hypothyroidism) usually owing to maternal hypothyroidism.

Fontanelle

fontanelfontanellesfontanels
If fetal deficiency was severe because of complete absence (athyreosis) of the gland, physical features may include a larger anterior fontanel, persistence of a posterior fontanel, an umbilical hernia, and a large tongue (macroglossia).

Macroglossia

enlarged tongueSwollen tongueenlargement of the tongue
If fetal deficiency was severe because of complete absence (athyreosis) of the gland, physical features may include a larger anterior fontanel, persistence of a posterior fontanel, an umbilical hernia, and a large tongue (macroglossia).

Thyroid-stimulating hormone

TSHthyroid stimulating hormonethyrotropin
Among specific defects are thyrotropin (TSH) resistance, iodine trapping defect, organification defect, thyroglobulin, and iodotyrosine deiodinase deficiency.

Failure to thrive

growth failurepoor growthfailed to thrive
If untreated for several months after birth, severe congenital hypothyroidism can lead to growth failure and permanent intellectual disability.

Thyroid hormones

thyroid hormonethyroxineT4
Congenital hypothyroidism (CH) is a condition of thyroid hormone deficiency present at birth.

Hypersomnia

hypersomnolenceoversleepingexcessive sleepiness
Infants born with congenital hypothyroidism may show no effects, or may display mild effects that often go unrecognized as a problem: excessive sleeping, reduced interest in nursing, poor muscle tone, low or hoarse cry, infrequent bowel movements, exaggerated jaundice, and low body temperature.

Breastfeeding

breast feedingbreastfeedbreast-feeding
Infants born with congenital hypothyroidism may show no effects, or may display mild effects that often go unrecognized as a problem: excessive sleeping, reduced interest in nursing, poor muscle tone, low or hoarse cry, infrequent bowel movements, exaggerated jaundice, and low body temperature.

Hypotonia

low muscle tonefloppy infant syndromepoor muscle tone
Infants born with congenital hypothyroidism may show no effects, or may display mild effects that often go unrecognized as a problem: excessive sleeping, reduced interest in nursing, poor muscle tone, low or hoarse cry, infrequent bowel movements, exaggerated jaundice, and low body temperature.

Neonatal jaundice

jaundicejaundice, neonatalJaundice in babies
Infants born with congenital hypothyroidism may show no effects, or may display mild effects that often go unrecognized as a problem: excessive sleeping, reduced interest in nursing, poor muscle tone, low or hoarse cry, infrequent bowel movements, exaggerated jaundice, and low body temperature.

Hypothermia

exposurehypothermiclow body temperature
Infants born with congenital hypothyroidism may show no effects, or may display mild effects that often go unrecognized as a problem: excessive sleeping, reduced interest in nursing, poor muscle tone, low or hoarse cry, infrequent bowel movements, exaggerated jaundice, and low body temperature.

Umbilical hernia

umbilicalhernia, umbilicalabdomen
If fetal deficiency was severe because of complete absence (athyreosis) of the gland, physical features may include a larger anterior fontanel, persistence of a posterior fontanel, an umbilical hernia, and a large tongue (macroglossia).

Intelligence quotient

IQIQ testI.Q.
Persistence of severe, untreated hypothyroidism resulted in severe mental impairment, with an IQ below 80 in the majority.

Iodine

II 2 iodinated
Around the world, the most common cause of congenital hypothyroidism is iodine deficiency, but in most of the developed world and areas of adequate environmental iodine, cases are due to a combination of known and unknown causes.

Genetic disorder

genetic diseasegenetic disordersgenetic diseases
Some of these cases of developmentally abnormal glands result from genetic defects, and some are "sporadic," with no identifiable cause.

Organochloride

organochlorineorganochlorine compoundchlorinated hydrocarbon
One Japanese study found a statistical correlation between certain organochlorine insecticides and dioxin-like chemicals in the milk of mothers who had given birth to infants with congenital hypothyroidism.

Insecticide

insecticidesinsecticidalsystemic insecticide
One Japanese study found a statistical correlation between certain organochlorine insecticides and dioxin-like chemicals in the milk of mothers who had given birth to infants with congenital hypothyroidism.

Polychlorinated dibenzodioxins

dioxindioxinsdioxine
One Japanese study found a statistical correlation between certain organochlorine insecticides and dioxin-like chemicals in the milk of mothers who had given birth to infants with congenital hypothyroidism.

Lithium (medication)

lithiumlithium saltslithium salt
Neonatal hypothyroidism has been reported in cases of infants exposed to lithium, a mood stabilizer used to treat bipolar disorder, in utero.

Mood stabilizer

mood stabilizersmood-stabilizingmood stabiliser
Neonatal hypothyroidism has been reported in cases of infants exposed to lithium, a mood stabilizer used to treat bipolar disorder, in utero.

Bipolar disorder

bipolarmanic depressionmanic depressive
Neonatal hypothyroidism has been reported in cases of infants exposed to lithium, a mood stabilizer used to treat bipolar disorder, in utero.

In utero

unborn childuteroCryo Interactive
Neonatal hypothyroidism has been reported in cases of infants exposed to lithium, a mood stabilizer used to treat bipolar disorder, in utero.