Connecting tubule

collecting tubulerenal collecting tubule
In the kidney, the connecting tubule (CNT, or junctional tubule, or arcuate renal tubule) is a tubular segment of the renal collecting duct system that connects the distal convoluted tubule to the cortical collecting duct.wikipedia
24 Related Articles

Distal convoluted tubule

distal tubuledistal convoluted tubulesdistal tubules
In the kidney, the connecting tubule (CNT, or junctional tubule, or arcuate renal tubule) is a tubular segment of the renal collecting duct system that connects the distal convoluted tubule to the cortical collecting duct.
The distal convoluted tubule (DCT) is a portion of kidney nephron between the loop of Henle and the collecting tubule.

Collecting duct system

collecting ductcortical collecting ductcollecting ducts
In the kidney, the connecting tubule (CNT, or junctional tubule, or arcuate renal tubule) is a tubular segment of the renal collecting duct system that connects the distal convoluted tubule to the cortical collecting duct.

Nephron

renal tubulenephronsrenal tubules
However, the embryological origin is more similar to the nephron than it is to the rest of the collecting duct (which derives from the ureteric bud), and other sources therefore classify the connecting tubule with the nephron.
The tubule has five anatomically and functionally different parts: the proximal tubule, which has a convoluted section the proximal convoluted tubule followed by a straight section (proximal straight tubule); the loop of Henle, which has two parts, the descending loop of Henle ("descending loop") and the ascending loop of Henle ("ascending loop"); the distal convoluted tubule ("distal loop"); the connecting tubule, and the collecting ducts.

Vasopressin

antidiuretic hormoneADHarginine vasopressin
The CNT is sensitive to both isoprotenerol (more so than the cortical collecting ducts) and antidiuretic hormone (less so than the cortical collecting ducts), the latter largely determining its function in water reabsorption.

Kidney

kidneysrenalkidney disorder
In the kidney, the connecting tubule (CNT, or junctional tubule, or arcuate renal tubule) is a tubular segment of the renal collecting duct system that connects the distal convoluted tubule to the cortical collecting duct.

Ureteric bud

metanephric
However, the embryological origin is more similar to the nephron than it is to the rest of the collecting duct (which derives from the ureteric bud), and other sources therefore classify the connecting tubule with the nephron.

Water

H 2 OHOliquid water
It participates in the regulation of water and electrolytes, including sodium, and chloride.

Electrolyte

electrolyteselectrolyticionic solution
It participates in the regulation of water and electrolytes, including sodium, and chloride.

Sodium

NaNa + sodium ion
It participates in the regulation of water and electrolytes, including sodium, and chloride.

Chloride

Cl − chloridesCl
It participates in the regulation of water and electrolytes, including sodium, and chloride.

Isoprenaline

isoproterenolIsuprelAerolone
The CNT is sensitive to both isoprotenerol (more so than the cortical collecting ducts) and antidiuretic hormone (less so than the cortical collecting ducts), the latter largely determining its function in water reabsorption.

Mineralocorticoid

mineralocorticoidsmineralcorticoidantinatriuretic agent
Aldosterone acts on the kidneys to provide active reabsorption of sodium and an associated passive reabsorption of water, as well as the active secretion of potassium in the principal cells of the cortical collecting tubule and active secretion of protons via proton ATPases in the lumenal membrane of the intercalated cells of the collecting tubule.

Chlortalidone

chlorthalidone(Chlorthalidone)Clortalidone
Giving chlortalidone while simultaneously restricting dietary sodium intake causes mild hypovolemia (low intravascular volume), which induces isotonic reabsorption of solute from the proximal renal tubule, reducing solute delivery in the renal collecting tubule and renal medullary collecting duct.

WNK1

WNK1 regulates potassium channels found in the cortical collecting duct (CCD) and connecting tubule (CNT).

Triamterene

DyreniumDytac
Triamterene directly blocks the epithelial sodium channel (ENaC) on the lumen side of the kidney collecting tubule.

Syndrome of inappropriate antidiuretic hormone secretion

SIADHsyndrome of inappropriate antidiuretic hormoneSyndrome of inappropriate secretion of antidiuretic hormone
Excessive ADH causes an inappropriate increase in the reabsorption in the kidneys of solute-free water ("free water"): excess water moves from the distal convoluted tubules (DCT)s and collecting tubules of the nephrons - via activation of aquaporins, the site of the ADH receptors - back into the circulation.

Renal urea handling

cycling of and excretion of urea by the kidneysUrea

Kidney development

metanephrosnephrogenesis
As the renal tubules grow, they come into contact and join with connecting tubules of the collecting duct system, forming a continuous passage for flow from the renal tubule to the collecting duct.

Index of oncology articles

List of oncology-related termscancer prophylaxis
– renal collecting tubule