Connexins (Cx) (TC# 1.A.24), or gap junction proteins, are structurally related transmembrane proteins that assemble to form vertebrate gap junctions.- Connexin
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Gap junctions are specialized intercellular connections between a multitude of animal cell-types.
In vertebrates, gap junction hemichannels are primarily homo- or hetero-hexamers of connexin proteins.
Protein that in humans is encoded by the GJA1 gene on chromosome 6.
As a connexin, GJA1 is a component of gap junctions, which allow for gap junction intercellular communication (GJIC) between cells to regulate cell death, proliferation, and differentiation.
Process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface.
Gap junctions are composed of channels called connexons, which consist of transmembrane proteins called connexins clustered in groups of six.
In biology, a connexon, also known as a connexin hemichannel, is an assembly of six proteins called connexins that form the pore for a gap junction between the cytoplasm of two adjacent cells.
Innexins are transmembrane proteins that form gap junctions in invertebrates.
While the connexin family of gap junction proteins was well-characterized in vertebrates, no homologues were found in non-chordates.
Pannexins (from Greek 'παν' — all, and from Latin 'nexus' — connection) are a family of vertebrate proteins identified by their homology to the invertebrate innexins.
Intercellular gap junctions in vertebrates, including humans, are formed by the connexin family of proteins.
Experimental method used by electrophysiologists to measure the ion currents through the membranes of excitable cells, such as neurons, while holding the membrane voltage at a set level.
When two cells in which gap junction proteins, typically connexins or innexins, are expressed, either endogenously or via injection of mRNA, a junction channel will form between the cells.
Cell junctions (or intercellular bridges ) are a class of cellular structures consisting of multiprotein complexes that provide contact or adhesion between neighboring cells or between a cell and the extracellular matrix in animals.
This is possible due to six connexin proteins interacting to form a cylinder with a pore in the centre called a connexon.
Pericytes (previously known as Rouget cells) are multi-functional mural cells of the microcirculation that wrap around the endothelial cells that line the capillaries throughout the body.
Important molecules in these intercellular connections include N-cadherin, fibronectin, connexin and various integrins.
One of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue.
Gap junctions connect the cytoplasm of two cells and are made up of proteins called connexins (six of which come together to make a connexion).