Cord factor

trehalose dimycolatecord factorscordingCording (mycobacterium)
Cord factor, or trehalose dimycolate, is a glycolipid molecule found in the cell wall of Mycobacterium tuberculosis and similar species.wikipedia
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Mycobacterium tuberculosis

M. tuberculosistubercle bacillusMycobacterium
Cord factor, or trehalose dimycolate, is a glycolipid molecule found in the cell wall of Mycobacterium tuberculosis and similar species.
For example, one such virulence factor is cord factor (trehalose dimycolate), which serves to increase survival within its host.

Mincle receptor

CLEC4EMincle
There is evidence that cord factor is recognized by the Mincle receptor, which is found on macrophages.
It is a pattern recognition receptor that can recognize glycolipids including mycobacterial cord factor, trehalose-6,6'-dimycolate (TDM).

Nocardia

N. veteranaNocardia caviaeNocardia sp.
* Nocardia
Majority of strains possess the cord factor (trehalose 6-6' dimycolate), an important virulence factor.

Glycolipid

glycolipidsglyceroglycolipid
Cord factor, or trehalose dimycolate, is a glycolipid molecule found in the cell wall of Mycobacterium tuberculosis and similar species.

SQ109

The antimycobacterial drug SQ109 is thought to inhibit TDM production levels and in this way disrupts its cell wall assembly.

Disaccharide

disaccharidesbiosidedi-
A cord factor molecule is composed of a trehalose sugar, a disaccharide, that is esterified to two mycolic acid residues.

Fibrinogen

β-fibrinogenI (fibrinogen)Afibrinogenemia
Furthermore, fibrinogen has shown to adsorb to monolayers of cord factor and act as a cofactor for its biological effects.

Cytokine

cytokineschemical signalscytokine-
An activated Mincle receptor leads to a pathway that ultimately results in the production of several cytokines.

Interleukin 12

IL-12interleukin-12IL12
Cord factor presence increases the production of the cytokines interleukin-12 (IL-12), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor (TNFα), and macrophage inflammatory protein-2 (MIP-2), which are all pro-inflammatory cytokines important for granuloma formation.

Interleukin 1 beta

IL-1βinterleukin-1βIL1B
Cord factor presence increases the production of the cytokines interleukin-12 (IL-12), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor (TNFα), and macrophage inflammatory protein-2 (MIP-2), which are all pro-inflammatory cytokines important for granuloma formation.

Interleukin 6

IL-6interleukin-6IL6
Cord factor presence increases the production of the cytokines interleukin-12 (IL-12), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor (TNFα), and macrophage inflammatory protein-2 (MIP-2), which are all pro-inflammatory cytokines important for granuloma formation.

Tumor necrosis factor alpha

TNF-αTNF-alphaTNFα
Cord factor presence increases the production of the cytokines interleukin-12 (IL-12), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor (TNFα), and macrophage inflammatory protein-2 (MIP-2), which are all pro-inflammatory cytokines important for granuloma formation.

CXCL3

macrophage inflammatory protein-2
Cord factor presence increases the production of the cytokines interleukin-12 (IL-12), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor (TNFα), and macrophage inflammatory protein-2 (MIP-2), which are all pro-inflammatory cytokines important for granuloma formation.

Granuloma

granulomatousgranulomasgranulomatous inflammation
When macrophages are activated by cord factor, they can arrange into granulomas around ''M.

Mycolic acid

mycolic acidsmycolate
The presence of mycolic acids in the cell wall also gives mycolata a distinct gross morphological trait known as "cording".

Dawn Bowdish

It was during this time that she discovered the role of MARCO (macrophage receptor with collagenous structure) in recognizing and eliciting an immune response against trehalose dimycolate, the main immunogenic component in the outer membrane of Mycobacterium tuberculosis