Corticotropin-releasing hormone

CRHcorticotropin releasing hormoneCRFcorticotropin releasing factorcorticotropin-releasing factorcorticotropin-releasing hormone (CRH)adrenal corticotropin releasing hormonecorticotrophin releasing hormonecorticotrophin-releasing factorcorticotropin release factor
Corticotropin-releasing hormone (CRH) (also known as corticotropin-releasing factor (CRF) or corticoliberin; corticotropin may also be spelled corticotrophin) is a peptide hormone involved in the stress response.wikipedia
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Corticotropin-releasing factor family

corticotropin-releasing factorCRFcorticotropin-releasing factor (CRF) gene
It is a releasing hormone that belongs to corticotropin-releasing factor family.
This family includes corticotropin-releasing hormone, urotensin-I, urocortin, and sauvagine.

Stress (biology)

stressenvironmental stressemotional stress
Corticotropin-releasing hormone (CRH) (also known as corticotropin-releasing factor (CRF) or corticoliberin; corticotropin may also be spelled corticotrophin) is a peptide hormone involved in the stress response. CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress.
The axis involves the release of corticotropin releasing hormone and vasopressin from the hypothalamus which stimulates the pituitary to secrete ACTH.

Hypothalamus

hypothalamicanterior hypothalamushypothalamic hormones
CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. CRH is produced by parvocellular neuroendocrine cells within the paraventricular nucleus of the hypothalamus and is released at the median eminence from neurosecretory terminals of these neurons into the primary capillary plexus of the hypothalamo-hypophyseal portal system.
Much smaller parvocellular neurosecretory cells, neurons of the paraventricular nucleus, release corticotropin-releasing hormone and other hormones into the hypophyseal portal system, where these hormones diffuse to the anterior pituitary.

Releasing and inhibiting hormones

releasing hormonehormone releaseinhibited
It is a releasing hormone that belongs to corticotropin-releasing factor family.

Corticorelin

Acthrel
A recombinant version for diagnostics is called corticorelin (INN).
It is a synthetic form of human corticotropin-releasing hormone (hCRH).

Corticotropic cell

corticotropeCorticotrophscorticotropes
The portal system carries the CRH to the anterior lobe of the pituitary, where it stimulates corticotropes to secrete adrenocorticotropic hormone (ACTH) and other biologically-active substances (β-endorphin).
These cells are stimulated by corticotropin releasing hormone (CRH) and make up 15–20% of the cells in the anterior pituitary.

Paraventricular nucleus of hypothalamus

paraventricular nucleusparaventricular hypothalamic nucleusparaventricular
CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. CRH is produced by parvocellular neuroendocrine cells within the paraventricular nucleus of the hypothalamus and is released at the median eminence from neurosecretory terminals of these neurons into the primary capillary plexus of the hypothalamo-hypophyseal portal system.
Inputs from glucose sensors within the brain stimulate release of vasopressin and corticotropin-releasing hormone from parvocellular neurosecretory cells.

Adrenocorticotropic hormone

ACTHcorticotropinadrenocorticotrophic hormone
The portal system carries the CRH to the anterior lobe of the pituitary, where it stimulates corticotropes to secrete adrenocorticotropic hormone (ACTH) and other biologically-active substances (β-endorphin). Its main function is the stimulation of the pituitary synthesis of ACTH, as part of the HPA Axis.
ACTH is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with its precursor corticotropin-releasing hormone from the hypothalamus).

Hypophyseal portal system

hypothalamo-hypophyseal portal systemhypothalamo-hypophyseal systemblood vessels that supply the anterior pituitary
CRH is produced by parvocellular neuroendocrine cells within the paraventricular nucleus of the hypothalamus and is released at the median eminence from neurosecretory terminals of these neurons into the primary capillary plexus of the hypothalamo-hypophyseal portal system.
The main hormones transported by the system include gonadotropin-releasing hormone, corticotropin-releasing hormone, growth hormone–releasing hormone, and thyrotropin-releasing hormone.

Cortisol

stress hormonestress hormoneshydrocortisone
ACTH stimulates the synthesis of cortisol, glucocorticoids, mineralocorticoids and DHEA.
Though IL-1 is useful in combating some diseases, endotoxic bacteria have gained an advantage by forcing the hypothalamus to increase cortisol levels (forcing the secretion of corticotropin-releasing hormone, thus antagonizing IL-1).

Pexacerfont

The CRH-1 receptor antagonist pexacerfont is currently under
Corticotropin-releasing factor (CRF), also known as corticotropin-releasing hormone, is an endogenous peptide hormone which is released in response to various triggers such as chronic stress.

Anterior pituitary

anterior pituitary glandanterior lobeanterior lobe of the pituitary gland
The portal system carries the CRH to the anterior lobe of the pituitary, where it stimulates corticotropes to secrete adrenocorticotropic hormone (ACTH) and other biologically-active substances (β-endorphin).
Corticotropin releasing hormone (CRH) from the hypothalamus stimulates ACTH release in a cascading effect that ends with the production of glucocorticoids from the adrenal cortex.

Parvocellular neurosecretory cell

Parvocellular neurosecretory neuronsparvicellular neurosecretory nucleiparvocellular
CRH is produced by parvocellular neuroendocrine cells within the paraventricular nucleus of the hypothalamus and is released at the median eminence from neurosecretory terminals of these neurons into the primary capillary plexus of the hypothalamo-hypophyseal portal system.

Corticotropin-releasing hormone receptor

corticotropin releasing hormone receptorCRF receptorCRF receptors
Corticotropin-releasing hormone receptors (CRHRs), also known as corticotropin-releasing factor receptors (CRFRs) are a G protein-coupled receptor family that binds corticotropin-releasing hormone (CRH).

Hypothalamic–pituitary–adrenal axis

hypothalamic-pituitary-adrenal axisHPA axishypothalamic-pituitary-adrenal
Its main function is the stimulation of the pituitary synthesis of ACTH, as part of the HPA Axis.

Addison's disease

Addison’s diseaseAddisonAutoimmune adrenalitis
Secondary adrenal insufficiency is caused by not enough adrenocorticotropic hormone (ACTH) (produced by the pituitary gland) or CRH (produced by the hypothalamus).

Corticotropin-releasing hormone receptor 1

CRHR1corticotropin releasing hormone receptor 1CRF 1
Recent research has linked the activation of the CRH1 receptor with the euphoric feelings that accompany alcohol consumption.
CRF 1 is activated through the binding of CRF or a CRF-agonist.

Glucocorticoid

glucocorticoidssteroidssteroid
ACTH stimulates the synthesis of cortisol, glucocorticoids, mineralocorticoids and DHEA.
In addition to the effects listed above, use of high-dose steroids for more than a week begins to produce suppression of the patient's adrenal glands because the exogenous glucocorticoids suppress hypothalamic corticotropin-releasing hormone and pituitary adrenocorticotropic hormone.

Cushing's syndrome

Cushing syndromeCushing’s syndromehypercortisolism
The paraventricular nucleus (PVN) of the hypothalamus releases corticotropin-releasing hormone (CRH), which stimulates the pituitary gland to release adrenocorticotropin (ACTH).

Peptide

polypeptidepeptidespolypeptides
Corticotropin-releasing hormone (CRH) (also known as corticotropin-releasing factor (CRF) or corticoliberin; corticotropin may also be spelled corticotrophin) is a peptide hormone involved in the stress response.

Hormone

hormoneshormonalprohormone
Corticotropin-releasing hormone (CRH) (also known as corticotropin-releasing factor (CRF) or corticoliberin; corticotropin may also be spelled corticotrophin) is a peptide hormone involved in the stress response.

Gene

genesnumber of genesgene sequence
In humans, it is encoded by the CRH gene.

Alzheimer's disease

AlzheimerAlzheimer’s diseaseAlzheimer disease
Increased CRH production has been observed to be associated with Alzheimer's disease and major depression, and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia.

Major depressive disorder

depressionclinical depressionmajor depression
Increased CRH production has been observed to be associated with Alzheimer's disease and major depression, and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia.

Hypoglycemia

low blood sugarhypoglycaemiahypoglycemic
Increased CRH production has been observed to be associated with Alzheimer's disease and major depression, and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia.