A report on Locus coeruleus, Major depressive disorder and Creativity

Rhomboid fossa. (Locus coeruleus not labeled, but is very near [just lateral to] the colliculus facialis, which is labeled at center left.)
Sorrowing Old Man (At Eternity's Gate) by Vincent van Gogh (1890)
A picture of a lightbulb is associated with someone having an idea, an example of creativity.
Locus coeruleus and its influence pathways
An 1892 lithograph of a woman diagnosed with melancholia
Greek philosophers like Plato rejected the concept of creativity, preferring to see art as a form of discovery. Asked in The Republic, "Will we say, of a painter, that he makes something?", Plato answers, "Certainly not, he merely imitates."
A cup analogy demonstrating the diathesis–stress model that under the same amount of stressors, person 2 is more vulnerable than person 1, because of their predisposition.
Distributed functional brain network associated with divergent thinking
Caricature of a man with depression
Training meeting in an eco-design stainless steel company in Brazil. The leaders among other things wish to cheer and encourage the workers in order to achieve a higher level of creativity.
Physical exercise is one recommended way to manage mild depression.
Sertraline (Zoloft) is used primarily to treat major depression in adults.
Diagnoses of depression go back at least as far as Hippocrates.
The 16th American president, Abraham Lincoln, had "melancholy", a condition that now may be referred to as clinical depression.

Behavioral and cognitive flexibility, creativity, behavioral inhibition and stress (psychological)

- Locus coeruleus

The locus coeruleus may figure in clinical depression, panic disorder, Parkinson's disease, Alzheimer's disease and anxiety.

- Locus coeruleus

Third, decreased size of the locus coeruleus, decreased activity of tyrosine hydroxylase, increased density of alpha-2 adrenergic receptor, and evidence from rat models suggest decreased adrenergic neurotransmission in depression.

- Major depressive disorder

This interdisciplinary framework integrates theoretical principles and empirical results from neuroeconomics, reinforcement learning, cognitive neuroscience, and neurotransmission research on the locus coeruleus system.

- Creativity

Particularly strong links have been identified between creativity and mood disorders, particularly manic-depressive disorder (a.k.a. bipolar disorder) and depressive disorder (a.k.a. unipolar disorder).

- Creativity

There has been a continuing discussion of whether neurological disorders and mood disorders may be linked to creativity, a discussion that goes back to Aristotelian times.

- Major depressive disorder
Rhomboid fossa. (Locus coeruleus not labeled, but is very near [just lateral to] the colliculus facialis, which is labeled at center left.)

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