Crohn's disease

Crohn’s diseasechronCrohnregional enteritisCrohn DiseaseCDCrohn's colitisCrohn's disease (CD)Crohn’sgranulomatous colitis
Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any part of the gastrointestinal tract from mouth to anus.wikipedia
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Management of Crohn's disease

Treatment options
Treatment options are intended to help with symptoms, maintain remission, and prevent relapse.
Since Crohn's disease is an immune system condition, it cannot be cured by medication or surgery.

Erythema nodosum

erythema nodosum leprosumerythema nodosum leprosum (ENL)acute erythema nodosum
The skin rashes may be due to infections as well as pyoderma gangrenosum or erythema nodosum.
Ulcerating forms, seen in Crohn's disease

Arthritis

arthriticjoint inflammationarthritic changes
Other complications may occur outside the gastrointestinal tract and include anemia, skin rashes, arthritis, inflammation of the eye, and tiredness.
Inflammatory bowel disease (including Crohn's disease and ulcerative colitis)

Uveitis

iritisiridocyclitisanterior uveitis
Other complications may occur outside the gastrointestinal tract and include anemia, skin rashes, arthritis, inflammation of the eye, and tiredness.
Crohn's disease

Methotrexate

amethopterin(M)'''ethotrexateFolex
In those newly diagnosed, a corticosteroid may be used for a brief period of time to rapidly improve symptoms alongside another medication such as either methotrexate or a thiopurine used to prevent recurrence.
Types of autoimmune diseases it is used for include psoriasis, rheumatoid arthritis, and Crohn's disease.

Abdominal pain

stomach acheupset stomachstomachache
Signs and symptoms often include abdominal pain, diarrhea (which may be bloody if inflammation is severe), fever, and weight loss.
Inflammatory: gastroenteritis, appendicitis, gastritis, esophagitis, diverticulitis, Crohn's disease, ulcerative colitis, microscopic colitis

Burrill Bernard Crohn

Dr. Burrill B. Crohn
The disease was named after gastroenterologist Burrill Bernard Crohn, who, in 1932, together with two other colleagues at Mount Sinai Hospital in New York, described a series of patients with inflammation of the terminal ileum of the small intestine, the area most commonly affected by the illness.
Burrill Bernard Crohn (June 13, 1884 – July 29, 1983 ) was an American gastroenterologist and made the first major advance to identify the disease that now bears his name.

Colitis

pseudomembranous colitiscolon inflammationinfectious colitis
Colitis may result in a smaller volume of feces of higher frequency.
The cause of the inflammation in the colon is undetermined; for example, colitis may be applied to Crohn's disease at a time when the diagnosis is unknown, or

Fecal incontinence

incontinencebowel controlfaecal incontinence
Fecal incontinence may accompany perianal Crohn's disease.
The most common causes are thought to be immediate or delayed damage from childbirth, complications from prior anorectal surgery (especially involving the anal sphincters or hemorrhoidal vascular cushions), altered bowel habits (e.g., caused by irritable bowel syndrome, Crohn's disease, ulcerative colitis, food intolerance, or constipation with overflow incontinence), and receptive anal sex.

Ulcerative colitis

Colitiscolitis ulcerosainflammatory colitis
Although the association is greater in the context of ulcerative colitis, Crohn's disease may also be associated with primary sclerosing cholangitis, a type of inflammation of the bile ducts.
It is a kind of inflammatory bowel disease (IBD) along with Crohn's disease and microscopic colitis.

Diarrhea

diarrhoeadiarrheal diseaseschronic diarrhea
Signs and symptoms often include abdominal pain, diarrhea (which may be bloody if inflammation is severe), fever, and weight loss.
This occurs with inflammatory bowel diseases, such as Crohn's disease or ulcerative colitis, and other severe infections such as E. coli or other forms of food poisoning.

Colonoscopy

colonoscopiescolonoscopecolonoscopic
Checking for bowel cancer via colonoscopy is recommended every few years, starting eight years after the disease has begun.
In most cases the positive result is just due to hemorrhoids; however, it can also be due to diverticulosis, inflammatory bowel disease (Crohn's disease, ulcerative colitis), colon cancer, or polyps.

Biopsy

biopsiestissue biopsybiopsied
Diagnosis is based on a number of findings including biopsy and appearance of the bowel wall, medical imaging and description of the disease.
In inflammatory bowel disease (Crohn's disease and ulcerative colitis), frequent biopsies are taken to assess the activity of disease and to assess changes that precede malignancy.

Malabsorption

malabsorption syndromeintestinal malabsorptionmalabsorption of nutrients
People with extensive small intestine disease may also have malabsorption of carbohydrates or lipids, which can further exacerbate weight loss.
For example, pain is common in patients with chronic pancreatitis or pancreatic cancer and Crohn's disease, but it is absent in many patients with coeliac disease or postgastrectomy malabsorption.

Skin tag

skin tagsacrochordonFibroepithelial polyp
Perianal skin tags are also common in Crohn's disease and may appear with or without the presence of colorectal polyps.
Perianal skin tags can be associated with Crohn's disease.

Bowel obstruction

intestinal obstructionobstructionsmall bowel obstruction
Bowel obstruction may occur as a complication of chronic inflammation, and those with the disease are at greater risk of bowel cancer.
Crohn's disease causing adhesions or inflammatory strictures

Corticosteroid

corticosteroidssteroidssteroid
In those newly diagnosed, a corticosteroid may be used for a brief period of time to rapidly improve symptoms alongside another medication such as either methotrexate or a thiopurine used to prevent recurrence.
Crohn's disease

Orofacial granulomatosis

cheilitis granulomatosagranulomatous cheilitis
In the oral cavity people with Crohn's may develop cheilitis granulomatosa and other forms of orofacial granulomatosis, pyostomatitis vegetans, recurrent aphthous stomatitis, geographic tongue, and migratory stomatitis in higher prevalence than the general population.
The underlying cause of the condition is not completely understood, and there is disagreement as to how it relates to Crohn's disease and sarcoidosis.

Abscess

abscessespustularincisional abscess
While surgery should be used as little as possible, it is necessary to address some abscesses, certain bowel obstructions, and cancers. Itchiness or pain around the anus may be suggestive of inflammation, fistulization or abscess around the anal area or anal fissure.
Perianal abscesses can be seen in patients with for example inflammatory bowel disease (such as Crohn's disease) or diabetes.

Failure to thrive

growth failurepoor growthFailure to thrive (FTT)
Among children, growth failure is common.
Endogenous (or "organic"):Causes are due to physical or mental issues with the child itself. It can include various inborn errors of metabolism. Problems with the gastrointestinal system such as excessive gas and acid reflux are painful conditions which may make the child unwilling to take in sufficient nutrition. Cystic fibrosis, diarrhea, liver disease, anemia or iron deficiency, Crohn's disease, and coeliac disease make it more difficult for the body to absorb nutrition. Other causes include physical deformities such as cleft palate and tongue tie. Milk allergies can cause endogenous FTT. FAS has also been associated with failure to thrive. Also the metabolism may be raised by parasites, asthma, urinary tract infections, and other fever-inducing infections, hyperthyroidism or congenital heart disease, so that it becomes difficult to get in sufficient calories to meet the higher caloric demands.

Thiopurine

thiopurines
In those newly diagnosed, a corticosteroid may be used for a brief period of time to rapidly improve symptoms alongside another medication such as either methotrexate or a thiopurine used to prevent recurrence.
The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis), and organ transplant recipients.

Gastrointestinal tract

intestinegastrointestinaldigestive tract
Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any part of the gastrointestinal tract from mouth to anus.
Inflammatory bowel disease is an inflammatory condition affecting the bowel walls, and includes the subtypes Crohn's disease and ulcerative colitis.

Anal fissure

anal fissuresAnal bleedingfissurectomy
Itchiness or pain around the anus may be suggestive of inflammation, fistulization or abscess around the anal area or anal fissure.
Crohn's disease

Pyoderma gangrenosum

The skin rashes may be due to infections as well as pyoderma gangrenosum or erythema nodosum.
Crohn's disease

Gastroenteritis

stomach flucholera morbusinfectious diarrhea
It also often begins after gastroenteritis.
Crohn's disease is also a non-infectious source of (often severe) gastroenteritis.