DAHP synthase

3-deoxy-7-phosphoheptulonate synthaseEC 2.5.1.54
3-Deoxy-D-arabinoheptulosonate 7-phosphate (DAHP) synthase is the first enzyme in a series of metabolic reactions known as the shikimate pathway, which is responsible for the biosynthesis of the amino acids phenylalanine, tyrosine, and tryptophan.wikipedia
33 Related Articles

Shikimate pathway

shikimic acid pathwaypathwayShikimate acid pathway
3-Deoxy-D-arabinoheptulosonate 7-phosphate (DAHP) synthase is the first enzyme in a series of metabolic reactions known as the shikimate pathway, which is responsible for the biosynthesis of the amino acids phenylalanine, tyrosine, and tryptophan.
The seven enzymes involved in the shikimate pathway are DAHP synthase, 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate dehydrogenase, shikimate kinase, EPSP synthase, and chorismate synthase.

3-Deoxy-D-arabino-heptulosonic acid 7-phosphate

3-deoxy-D-arabinoheptulosonate-7-phosphate3-deoxy- D -arabinoheptulosonate-7-phosphate3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate
The three substrates of this enzyme are phosphoenolpyruvate, D-erythrose 4-phosphate, and H 2 O, whereas its two products are 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate and phosphate.
Phosphoenolpyruvate and erythrose-4-phosphate react to form 3-deoxy--arabinoheptulosonate-7-phosphate (DAHP), in a reaction catalyzed by the enzyme DAHP synthase.

Erythrose 4-phosphate

erythrose-4-phosphateD-erythrose 4-phosphate D -erythrose 4-phosphate
The three substrates of this enzyme are phosphoenolpyruvate, D-erythrose 4-phosphate, and H 2 O, whereas its two products are 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate and phosphate.
At this stage, phosphoenolpyruvate and erythrose-4-phosphate react to form 3-deoxy-D-arabinoheptulosonate-7-phosphate (DAHP), in a reaction catalyzed by the enzyme DAHP synthase.

Phosphoenolpyruvic acid

phosphoenolpyruvatePEPphosphoenol pyruvate
The three substrates of this enzyme are phosphoenolpyruvate, D-erythrose 4-phosphate, and H 2 O, whereas its two products are 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate and phosphate.
The first step is when Phosphoenolpyruvate and erythrose-4-phosphate react to form 3-deoxy-D-arabinoheptulosonate-7-phosphate (DAHP), in a reaction catalyzed by the enzyme DAHP synthase.

Metabolism

metabolicmetabolizedmetabolic pathways
3-Deoxy-D-arabinoheptulosonate 7-phosphate (DAHP) synthase is the first enzyme in a series of metabolic reactions known as the shikimate pathway, which is responsible for the biosynthesis of the amino acids phenylalanine, tyrosine, and tryptophan.

Chemical reaction

reactionchemical reactionsreactions
3-Deoxy-D-arabinoheptulosonate 7-phosphate (DAHP) synthase is the first enzyme in a series of metabolic reactions known as the shikimate pathway, which is responsible for the biosynthesis of the amino acids phenylalanine, tyrosine, and tryptophan. In enzymology, a DAHP synthase is an enzyme that catalyzes the chemical reaction

Biosynthesis

productionsynthesisbiosynthetic
3-Deoxy-D-arabinoheptulosonate 7-phosphate (DAHP) synthase is the first enzyme in a series of metabolic reactions known as the shikimate pathway, which is responsible for the biosynthesis of the amino acids phenylalanine, tyrosine, and tryptophan.

Amino acid

amino acidsresiduesresidue
3-Deoxy-D-arabinoheptulosonate 7-phosphate (DAHP) synthase is the first enzyme in a series of metabolic reactions known as the shikimate pathway, which is responsible for the biosynthesis of the amino acids phenylalanine, tyrosine, and tryptophan.

Phenylalanine

PheL-phenylalaninephenylalanine metabolism
3-Deoxy-D-arabinoheptulosonate 7-phosphate (DAHP) synthase is the first enzyme in a series of metabolic reactions known as the shikimate pathway, which is responsible for the biosynthesis of the amino acids phenylalanine, tyrosine, and tryptophan.

Tyrosine

Tyrtyrosine metabolismL-tyrosine
3-Deoxy-D-arabinoheptulosonate 7-phosphate (DAHP) synthase is the first enzyme in a series of metabolic reactions known as the shikimate pathway, which is responsible for the biosynthesis of the amino acids phenylalanine, tyrosine, and tryptophan.

Tryptophan

L-tryptophanTrptryptophan metabolism
3-Deoxy-D-arabinoheptulosonate 7-phosphate (DAHP) synthase is the first enzyme in a series of metabolic reactions known as the shikimate pathway, which is responsible for the biosynthesis of the amino acids phenylalanine, tyrosine, and tryptophan.

Enzyme inhibitor

inhibitorinhibitioninhibitors
Enzyme inhibition is the primary method of regulating the amount of carbon entering the pathway.

Enzyme

enzymologyenzymesenzymatic
In enzymology, a DAHP synthase is an enzyme that catalyzes the chemical reaction

Catalysis

catalyzescatalysescatalyst
In enzymology, a DAHP synthase is an enzyme that catalyzes the chemical reaction

Substrate (chemistry)

substratessubstratesubstrate specificity
The three substrates of this enzyme are phosphoenolpyruvate, D-erythrose 4-phosphate, and H 2 O, whereas its two products are 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate and phosphate.

Water

H 2 OHOliquid water
The three substrates of this enzyme are phosphoenolpyruvate, D-erythrose 4-phosphate, and H 2 O, whereas its two products are 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate and phosphate.

Product (chemistry)

productsproductchemical products
The three substrates of this enzyme are phosphoenolpyruvate, D-erythrose 4-phosphate, and H 2 O, whereas its two products are 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate and phosphate.

Phosphate

phosphatesphosphate groupinorganic phosphate
The three substrates of this enzyme are phosphoenolpyruvate, D-erythrose 4-phosphate, and H 2 O, whereas its two products are 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate and phosphate.

Transferase

transferasesformyltransferasehydroxymethyltransferase
This enzyme belongs to the family of transferases, to be specific those transferring aryl or alkyl groups other than methyl groups.

List of enzymes

systematic nameclassifiedList of EC numbers
The systematic name of this enzyme class is phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming).

Escherichia coli

E. coliE.coliE-coli
In Escherichia coli, a species of bacteria, DAHP synthase is found as three isoenzymes, each of which sensitive to one of the amino acids produced in the shikimate pathway.

Isozyme

isoenzymeisozymesisoenzymes
In Escherichia coli, a species of bacteria, DAHP synthase is found as three isoenzymes, each of which sensitive to one of the amino acids produced in the shikimate pathway.

Cysteine

CysL-cysteinecystein
In DAHP synthase, it has been shown that binding site contains patterns of cysteine and histidine residues bound to metal ions in a Cys-X-X-His fashion.

Histidine

Hishistidine metabolismhistidines
In DAHP synthase, it has been shown that binding site contains patterns of cysteine and histidine residues bound to metal ions in a Cys-X-X-His fashion.

Cofactor (biochemistry)

cofactorcofactorscoenzyme
It has been shown that, in general, DAHP synthases require a bivalent metal ion cofactor in order for the enzyme to function properly.